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Keywords = iso-PhABA analogs

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15 pages, 748 KB  
Communication
Synthesis and Biological Activity of 2′,3′-iso-Aryl-abscisic Acid Analogs
by Chuan Wan, Mingan Wang, Dongyan Yang, Xiaoqiang Han, Chuanliang Che, Shanshan Ding, Yumei Xiao and Zhaohai Qin
Molecules 2017, 22(12), 2229; https://doi.org/10.3390/molecules22122229 - 15 Dec 2017
Cited by 13 | Viewed by 4634
Abstract
2′,3′-iso-Benzoabscisic acid (iso-PhABA), an excellent selective abscisic acid (ABA) analog, was developed in our previous work. In order to find its more structure-activity information, some structural modifications were completed in this paper, including the substitution of phenyl ring and [...] Read more.
2′,3′-iso-Benzoabscisic acid (iso-PhABA), an excellent selective abscisic acid (ABA) analog, was developed in our previous work. In order to find its more structure-activity information, some structural modifications were completed in this paper, including the substitution of phenyl ring and replacing the ring with heterocycles. Thus, 16 novel analogs of iso-PhABA were synthesized and screened with three bioassays, Arabidopsis and lettuce seed germination and rice seedling elongation. Some of them, i.e., 2′,3′-iso-pyridoabscisic acid (iso-PyABA) and 2′,3′-iso-franoabscisic acid (iso-FrABA), displayed good bioactivities that closed to iso-PhABA and natural (+)-ABA. Some others, for instance, substituted-iso-PhABA, exhibited certain selectivity to different physiological process when compared to iso-PhABA or (+)-ABA. These analogs not only provided new candidates of ABA-like synthetic plant growth regulators (PGRs) for practical application, but also new potential selective agonist/antagonist for probing the specific function of ABA receptors. Full article
(This article belongs to the Section Medicinal Chemistry)
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