Search Results (3)

This study introduces two novel Schiff base ligands synthesized through the condensation of isatin with primary amines. These ligands were characterized using infrared (IR), ultraviolet-visible (UV-Vis) spectroscopy, mass spectrometry, and elemental analysis. The ligands were further treated with tetrathiocyanate in a 1:1 molar ratio to yield binuclear mixed-metal monomeric bridged complexes of the form LMCd(SCN)₄, where M represents Co(II) or Ni(II). Various spectral techniques and magnetic susceptibility measurements were employed for the identification of these complexes. The findings revealed that all the complexes possessed a coordination number of four and exhibited non-electrolytic behavior. Additionally, the cobalt complexes demonstrated paramagnetic properties, whereas the nickel complexes were diamagnetic. The antimicrobial efficacy of the Schiff base ligands and their complexes was also evaluated against selected microorganisms, revealing significant antimicrobial activities. Full article

Through the condensation of isatin (indoline-2, 3-dione) and aniline in a 1:1 ratio, a Schiff base ligand was synthesized and characterized via (¹H-NMR, mass, IR, UV-Vis) spectra. Elemental analyses, spectroscopy (¹H-NMR, mass, UV-Vis), magnetic susceptibility, molar conductivity, mass spectra, scanning electron microscope (SEM), and thermal analysis have all been used to characterize a series of Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II), and Cd(II) metal complexes derived from the titled ligand. The metal-to-ligand ratio is 1:1, according to the analytical data. The Schiff base ligand displayed bidentate behavior with NO coordination sites when it bonded to metal ions, as seen by the IR spectra. The magnetic moment measurement and UV-Vis spectral investigation showed the octahedral geometry of the Cr(III), Fe(III), Co(II), Ni(II), and Zn(II) complexes, whereas they suggested the tetrahedral geometry of the Mn(II), Cu(II), and Cd(II) complexes. The thermal analysis study confirmed the presence of both hydrated and coordinated water molecules in all the compounds, except for the Mn(II) complex, and showed that the complexes decomposed in three or five decomposition steps leaving the corresponding metal oxide as a residue. The ligand and its metal complexes’ antibacterial efficacy were evaluated. The findings showed that the metal complexes had stronger antibacterial properties than the ligand alone. The ligand and its metal complexes’ anticancer properties were also investigated. A DFT investigation is also reported to gather information regarding the electronic features of the ligand and its metal complexes. Finally, drug-likeness and ADME characteristics were also calculated as parameters. Full article

In the present study a series of Schiff bases of indoline-2,3-dione were synthesized and investigated for their Mtb gyrase inhibitory activity. Promising inhibitory activity was demonstrated with some of these derivatives, which exhibited IC₅₀ values ranging from 50–157 mM. The orientation and the ligand-receptor interactions of such molecules within the Mtb DNA gyrase A subunit active site were investigated applying a multi-step docking protocol using Molecular Operating Environment (MOE) and Autodock4 docking software. The results revealed the importance of the isatin moiety and the connecting side chain for strong interactions with the enzyme active site. Among the tested compounds the terminal aromatic ring benzofuran showed the best activity. Promising new leads for developing a novel class of Mtb gyrase inhibitors were obtained from Schiff bases of indoline-2,3-dione. Full article