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Keywords = high-speed mixer ball mill process

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Article
A Simple and Effective Protocol for the Pechmann Reaction to Obtain 4-Methylcoumarin Derivatives Using a High-Speed Mixer Ball Mill Process
by Silvia J. Becerra-Anaya, Diego R. Merchán Arenas and Vladimir V. Kouznetsov
Chemistry 2023, 5(2), 1077-1088; https://doi.org/10.3390/chemistry5020073 - 8 May 2023
Cited by 9 | Viewed by 5649
Abstract
We hereby report a simple and efficient method for the preparation of 4-methylcoumarins series, including Coumarin 120 (7-amino-4-methylcoumarin) from phenols (or naphthols) and ethyl acetoacetate in the presence of 3 mol% InCl3. Coumarins were obtained in good yields (52–92%) through Pechmann condensation, [...] Read more.
We hereby report a simple and efficient method for the preparation of 4-methylcoumarins series, including Coumarin 120 (7-amino-4-methylcoumarin) from phenols (or naphthols) and ethyl acetoacetate in the presence of 3 mol% InCl3. Coumarins were obtained in good yields (52–92%) through Pechmann condensation, under a rapid and environmentally friendly protocol using a high-speed ball mill mixer at room temperature, with short reaction times, under solvent-free conditions. Full article
(This article belongs to the Section Molecular Organics)
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