Search Results (5)

In this manuscript, we highlight the evolutionary origins of mitochondria from bacterial endosymbionts and explore their contributions to health, energy metabolism, and neural–immune communication. Mitochondrial adaptability and the roles played by these organelles in promoting oxygen-dependent ATP production provide critical regulation of cognition, motivation, and inflammation. Hypoxia has been identified as an important initiator of inflammation, neurodegeneration, and mitochondrial dysfunction, emphasizing the overall importance of oxygen homeostasis to health and well-being. The Behavior, Exercise, Relaxation, and Nutrition framework highlights these observations as tools that can be used to optimize mitochondrial efficiency. Interestingly, mitochondrial dysfunction may also be linked to psychiatric disorders (e.g., schizophrenia), a hypothesis that focuses on energy dynamics, a proposal that may extend our understanding of these disorders beyond traditional neurotransmitter-focused concepts. Collectively, these perspectives underscore the critical contributions of mitochondria to health and disease and offer a novel framework that may help to explain the connections featured in mind–body medicine. Full article

This paper explores the possibility of counteracting the crisis of culture and institutions by investing in the identity values of the user-actor within digital spaces built for the purpose. The strategy is applied to the analysis of three Catalan cloisters (Spain), with a focus on the representation of the cloister of Sant Cugat (Barcelona). Heuristic picklocks are found in the semantic richness proposed by Marius Schneider exclusively on the verbal level. The authors interpret the contents and transcribe them into graphic signs and digital denotations of sounds and colors. They organize proprietary ontologies, or syntagmatic lines, to be entrusted to the management of computer algorithms. The syncretic culture that characterized the medieval era allowed the ability to mediate science and faith to be entrusted to the mind of the praying monk alone in every canonical hour. The hypothesis that a careful direction has programmed the ways in which to orient souls to “navigate by sight” urges the authors to find the criteria that advanced statistics imitates to make automatic data processing “Intelligent”. In step with the times and in line with the most recent directions for the Safeguarding of Heritage, the musical, astral, and narrative rhythms feared by Schneider are used to inform representative models, to increase not only the visual perception of the user (XR Extended Reality) but also to solicit new analogies and illuminating associations. The results return a vision of the culture of the time suitable for shortening the distances between present and past, attracting the visitor and, with him, the resources necessary to protect and enhance the spaces of the Romanesque era. The methodology goes beyond the contingent aspect by encouraging the ‘remediation’ of contents with the help of machine learning. Full article

Technology is increasingly shaping human life, particularly in healthcare, where recent advancements have revolutionized patient care. Despite these advances, the World Health Organization’s (WHO) definition of health remains rooted in traditional notions, raising questions about its adequacy in light of technological progress. This paper explores the conceptual and practical limitations of the current definition and argues for its revision to encompass the role of technology in health. This paper examines the evolving landscape of healthcare technology and its philosophical implications, drawing on theories such as the Extended Health Hypothesis and the Extended Mind Hypothesis. It claims that health extends beyond traditional biological boundaries and includes the influence of technology on well-being. This paper advocates for a re-examination of the WHO definition of health to reflect the integral role of technology in modern healthcare. Recognizing technology as part of health necessitates a broader conceptual framework that acknowledges the interconnectedness of biology, technology, and human well-being. Given technology’s transformative role in healthcare, this paper argues for a revaluation of the WHO’s definition of health to encapsulate the evolving relationship between technology and human well-being. At the end, we propose a new definition recognizing that health is a dynamic state of physical, mental, social, and technological well-being, wherein individuals can achieve optimal quality of life through the harmonious integration of biological, psychological, and technological factors. This state encompasses not only the absence of disease but also the effective utilization of advanced technologies. Full article

Not all cancer patients respond to immunotherapy, and the variation in response may be attributed to an individual’s microbiome, which is profoundly influenced by dietary habits. Understanding and manipulating the microbiome through dietary interventions offers a potential avenue for enhancing immunotherapy outcomes in cancer patients and may consequently serve as a complementary therapeutic strategy. Bearing in mind the latter, as well as our previous research on the importance of the gut microbiome as a co-denominator for immunotherapy response, we aimed to construct this study protocol on a personalized dietary intervention based on the Mediterranean diet as a complementary strategy to modify the gut microbiome, quality of life and outcomes in patients with metastatic melanoma treated with immunotherapy. The present protocol hypothesis is that remote intervention with the MD will be achievable and will positively affect all the aforementioned parameters. The potential gains of this study protocol and upcoming research extend to enhancing quality-of-life outcomes and the survival rates of patients with metastatic melanoma since it could also result in the reinforcement of the recommendation of nutritional intervention as a crucial component of cancer treatment. Full article

Logan [1] in his book The Extended Mind developed the hypothesis that language, culture, technology and science can be treated as organisms that evolve and reproduce themselves. This idea is extended by making use of the notion of teleodynamics that Deacon [2] introduced and developed in his book Incomplete Nature to explain the nature of life, sentience, mind and a self that acts in its own interest. It is suggested that language, culture, technology and science (LCT&S) like living organisms also act in their own self-interest, are self-correcting and are to a certain degree autonomous even though they are obligate symbionts with their human hosts. Specifically, it will be argued that LCT&S are essentially teleodynamic systems, which Deacon defines as “self-creating, self-maintaining, self-reproducing, individuated systems [2] (p. 325)”. Full article