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Keywords = diynol

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Article
Total Synthesis of Chiral Falcarindiol Analogues Using BINOL-Promoted Alkyne Addition to Aldehydes
by Li Wang, Ping-Ping Shou, Si-Ping Wei, Chun Zhang, Shuang-Xun Li, Ping-Xian Liu, Xi Du and Qin Wang
Molecules 2016, 21(1), 112; https://doi.org/10.3390/molecules21010112 - 19 Jan 2016
Cited by 8 | Viewed by 7137
Abstract
An enantioselective total synthesis of chiral falcarindiol analogues from buta-1,3-diyn-1-yltriisopropylsilane is reported. The key step in this synthesis is BINOL-promoted asymmetric diacetylene addition to aldehydes. The two chiral centers of the falcarindiol analogues can be produced by using the same kind of catalyst [...] Read more.
An enantioselective total synthesis of chiral falcarindiol analogues from buta-1,3-diyn-1-yltriisopropylsilane is reported. The key step in this synthesis is BINOL-promoted asymmetric diacetylene addition to aldehydes. The two chiral centers of the falcarindiol analogues can be produced by using the same kind of catalyst with high selectivity, and the final product can be obtained in only six steps. Full article
(This article belongs to the Section Organic Chemistry)
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