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Total Synthesis of Chiral Falcarindiol Analogues Using BINOL-Promoted Alkyne Addition to Aldehydes
- Li Wang,
- Ping-Ping Shou,
- Si-Ping Wei,
- Chun Zhang,
- Shuang-Xun Li,
- Ping-Xian Liu,
- Xi Du and
- Qin Wang
An enantioselective total synthesis of chiral falcarindiol analogues from buta-1,3-diyn-1-yltriisopropylsilane is reported. The key step in this synthesis is BINOL-promoted asymmetric diacetylene addition to aldehydes. The two chiral centers of the f...