Search Results (57)

Background/Objectives: Patients with rheumatic diseases often experience pain-related depressive symptoms, potentially exacerbated by feelings of loneliness and social isolation. This study explores the role of mentalizing, i.e., the understanding of inner mental states in oneself and others, as a protective factor in this context. Methods: In this secondary analysis, n = 76 patients completed the FESV depression scale, MZQ UCLA loneliness scale and pain severity items from the German Pain Questionnaire. Structural equation models and mediation analyses were employed to test different theoretical models. Results: The best model fit was found for Model 3, which described the association of loneliness with pain severity (β = 0.34, p = 0.004). The association was fully mediated by a sequential mediation of mentalizing and pain-related depression. Adding the mediators increased the overall explained variance of pain severity from 12% to 41% with an excellent model fit (CFI > 0.99; TLI > 0.99; RMSEA = 0.001). Conclusions: The study suggests that patients’ pain severity may be influenced by the interaction between loneliness, depressive symptoms and mentalizing abilities. The negative impact of pain-related depressive symptoms and loneliness on pain severity underscores the need for their targeted management in routine care for chronic pain patients. Improvement of mentalizing may be a resilience factor for these patients. Full article

Background/Objectives: The aim of our study was to examine the influence of family structure and the number of siblings on psychological problems and illness-related emotions in children and adolescents with inflammatory bowel disease (IBD) and the relationship between emotional coping in children and parents. Methods: CEDNA is a nationwide German online and paper-based questionnaire administered between October 2021 and April 2022. Adolescents with IBD, aged 12 to 17 years, and parents of children aged 0 to 17 years with diagnosed IBD, were included. SAS was used for descriptive statistics and logistic regression analysis was performed using R Studio (PBC; 2023.06.0 + 421). Results: 1158 participants (450 adolescents and 708 parents) were included in the study. A two-parent household could not be associated with mental illness as a comorbidity in pediatric IBD patients (p = 0.06) but was shown to decrease the risk of sadness (p < 0.001), helplessness (p < 0.01), feeling left alone and lonely (p < 0.05). A single-parent household increased the risk of sadness (p = 0.001), helplessness (p = 0.002), and loneliness (p = 0.006). Having one to two siblings was associated with a lower risk of mental health problems (p = 0.03) and reduced anxiety (p = 0.005). An association was also found between parents and children’s emotional coping skills. Conclusions: Further research on family structure and siblings in pediatric IBD is needed, given the potential impact on children’s psychological well-being. Full article

Background and Objectives: In Kazakhstan, during the COVID-19 pandemic, older adults faced unique challenges, such as limited healthcare resources and prolonged periods of social isolation. The aim of our study was to evaluate the sociodemographic and health-related factors associated with loneliness and psychological distress in older adults during the COVID-19 pandemic in Kazakhstan. Materials and Methods: In this cross-sectional study, a total of 445 participants aged 60 and above were recruited from Kazakhstan during the COVID-19 pandemic. The Patient Health Questionnaire-4 (PHQ-4) was used to measure psychological distress, anxiety, and depression. Loneliness was assessed using the UCLA Loneliness Scale (UCLA-3). The sociodemographic and health-related variables of the tested participants were analyzed. Results: Mean values from the UCLA-3 (p < 0.001), PHQ-4 (p < 0.001), anxiety (p < 0.001), and depression (p < 0.001) scores significantly differed between different categories of self-reported overall health. Significantly higher mean values were found in older adults with hypertension for UCLA-3 (p = 0.025), PHQ-4 (p = 0.001), anxiety (p = 0.001), and depression (p = 0.017); diabetes for UCLA-3 (p = 0.023), PHQ-4 (p = 0.029), and depression (p = 0.001); chronic heart failure for UCLA-3 (p = 0.005), PHQ-4 (p < 0.001), anxiety (p = 0.001), and depression (p < 0.001); cerebrovascular disease for UCLA-3 (p = 0.024), PHQ-4 (p = 0.002), anxiety (p = 0.001), and depression (p = 0.027); cardiovascular disease for UCLA-3 (p < 0.001), PHQ-4 (p < 0.001), anxiety (p < 0.001), and depression (p < 0.001); dementia for anxiety (p = 0.046); being single for UCLA-3 (p = 0.009), PHQ-4 (p = 0.031), and depression (p = 0.028); other ethnic backgrounds for PHQ-4 (p = 0.004) and anxiety (p = 0.013); and living in an urban place for PHQ-4 (p = 0.043). Being single was shown to be a significant predictor for loneliness (OR 2.21; 95%CI 1.28–3.84), anxiety (OR 2.09; 95%CI 1.14–3.84), and depression (OR 4.23; 95%CI 1.95–9.15). Below-average (OR 5.79; 95%CI 1.09–30.90) self-reported overall health was shown to be a significant predictor of anxiety. Conclusions: Our study demonstrated that numerous sociodemographic and health-related factors were associated with loneliness, anxiety, and depression in older adults from Kazakhstan during the COVID-19 pandemic. Full article

This study explored women living with HIV (WLHIV)’s stigma-related emotional life and sense of self in a rural Zimbabwean setting. The objective of this study was to understand the sense of stigma in the emotional lives and self-perception of women living with HIV in rural Zimbabwe. The participants were a purposive sample of 20 rural women living with HIV. Their age ranged from 20 to 65 years old. WLHIV completed semi-structured individual interviews on their emotions and sense of life. The interpretive phenomenological analysis (IPA) revealed that these rural women living with HIV endure humiliation and isolation, leading them to feeling hopeless. Their society (significant others) perceived them as burdensome social others from which little could be expected. These women experience this sense of “otherness” that represents them as social outcasts, which results in a deep sense of social isolation and loneliness, worthlessness, withdrawal, and hopelessness. The women self-perceived themselves to be constantly managing their sense of dehumanization and being stereotyped as primarily with an identity defined by disease or illness by society. The findings suggest a need for the development and implementation of support programs for building healthy self-identities for women living with HIV. Such programs would focus on strategies that counteract societal and self-stigmatization living with HIV and AIDS for full community inclusion. Full article

Background: The global population is experiencing a demographic shift towards older ages, which has the potential to increase the prevalence of ageing-related diseases and associated healthcare costs. Promoting healthy ageing behaviours, such as physical and social activity, has been shown to reduce disability and frailty among older people and improve their life satisfaction. To this aim, several Healthy Ageing Centres have been established across nine municipalities in Bosnia and Herzegovina to support healthy ageing behaviours in older populations. This cross-sectional study hypothesises that participation in these centres will be associated with an increase in healthy behaviours. Methods: This exploratory study compares the behaviours of Healthy Ageing Centre members (n = 399) and non-members (n = 55) to assess if participation in Healthy Ageing Centres is associated with healthy ageing behaviours such as physical activity, social interactions, and life satisfaction. Results: Members at Healthy Ageing Centres had a higher life satisfaction, exercised for significantly longer, and engaged in social activities more frequently than non-members. No differences were found in diet, alcohol consumption or loneliness levels. Conclusions: The present study highlights the positive behaviours associated with attending Healthy Ageing Centres, suggesting that their establishment in ageing populations could be beneficial for supporting healthy ageing. Full article

Background: Chronic disease significantly influences mental health, identity, and self-esteem. It is deeply interconnected with loneliness, frailty, stress, mental health, and the ageing process, forming a complex and interrelated dynamic. The aim was to find an association between loneliness, frailty, mental health, and the patient’s self-management. Methods: A cross-sectional study was conducted between October 2023 and May 2024. A total of 605 patients with chronic disease took part in the research, of whom 67% were female and 33% were male. In total, 71% of participating patients lived in a home environment, and 19% lived in retirement homes. Results: 605 respondents with chronic disease participated in the study and were recruited using a purposive sampling method. Participants were drawn from healthcare settings, including primary care centres, outpatient clinics, and nursing homes, to increase representativeness. The study achieved a response rate of 55% after distributing 1100 questionnaires. Data were analysed with SPSS Statistics 25.0 using descriptive and inferential statistical methods, including non-parametric tests (Kruskal–Wallis test, Mann–Whitney U test) and Spearman’s correlation. The main results showed that patients who self-rated their chronic disease as well- or very well-managed (81%) were less frail (p < 0.001), less lonely (p < 0.001), and had better mental health (p = 0.015). Significant associations were found between frailty, loneliness (r_s = 0.428, p < 0.001), and lower mental health (r_s = 0.185, p < 0.001). In addition, frequent social contact was associated with lower frailty and loneliness (p < 0.001). Conclusions: Without adequate assessment and support from the healthcare system, patients may face challenges in meeting their needs, which can contribute to loneliness, frailty, and mental health decline. It is crucial to acknowledge that every individual with a chronic disease, regardless of age, education level, or condition, must actively participate in managing their chronic disease. Recognising the importance of self-management and its impact on mental health is essential to mitigating the negative effects of chronic disease on a patient’s quality of life. Full article

Background: Whether hemodialysis patients want caregivers to discuss spirituality is poorly studied, especially in Europe. The goal of this qualitative study was to explore the spirituality and spiritual expectations of hemodialysis patients in a Swiss dialysis center. Methods: Semi-structured, qualitative interviews were performed by an experienced sociologist with dialysis patients in the ambulatory dialysis unit of the University Hospital of Lausanne. The interviews included a set of open questions on the role that spirituality plays in patients’ lives, in coping with their illness and in the recent COVID-19 epidemic. All interviews were recorded, transcribed, coded and analyzed following the approach of content analysis. Findings: Twenty interviews were performed in 2022. In total, 14/20 patients practiced some form of religion (believers), four were agnostics, and two defined themselves as atheist. The majority (15/20) confirmed that spirituality plays a positive role to preserve hope and to manage the difficulties caused by the disease and its treatment; one out of four wishes to discuss spirituality in the hospital setting. The largest needs are related to social dimensions (isolation, loneliness, need to talk, financial problems). Their level of spirituality has not been impacted by the COVID-19 pandemic. Discussion: In this pilot study, spirituality in a broad sense was important for the majority of the patients, and a quarter of them would like it to be actively addressed by healthcare professionals. They also ask for more attention to social and socio-economic difficulties. Full article

Introduction: Hospitalisation and prolonged length of stay is associated with deconditioning that risks adverse outcomes after discharge. Less is known about the psychological impact on older people after hospital discharge. The purpose of this systematic review was to elucidate factors contributing to psychological stress in older patients post-discharge to inform better discharge planning. Methods: A systematic search for studies reporting poor discharge outcomes in older people between 2010 and 2022 was performed in Medline, CINAHL, and PsycINFO. Search terms were ‘older patients > 65 year’, ‘post-discharge’, ‘psychological distress’, ‘loneliness’, ‘anxiety’, ‘depression’, and ‘length of hospital stay’. Exclusion criteria included COVID-19 disease, dementia (±severe cognitive impairment), individuals aged <65, and those under palliative care services. Results: A total of 1666 records were identified, of which 878 were excluded as they were outside of our date limits or were not written in the English language, 681 were excluded after application of exclusion criteria, and 699 were excluded because of insufficient details. A total of 31 duplicates were removed, leaving 38 articles that were assessed for eligibility; 7 of these reports were found suitable, comprising 1131 patients. Three highly relevant themes identified relating to post-discharge outcomes were social isolation, lack of support, depression and anxiety. Older patients with a tendency toward depressive symptoms had an increased likelihood of death. Conclusions: It appears that the discharge process from hospital fails to address psychological factors that permit a successful transition from hospital. Pre-discharge screening of psychological symptoms and coping ability may assist in identifying older patients who are at risk of mental as well as subsequent physical deterioration. Better knowledge of positive and negative predictors of a successful transition from hospital to home would enable more holistic, effective, and inclusive discharge planning processes for older adults. Full article

Long-term sequelae of coronavirus disease 2019 (COVID-19) infection are common and can have debilitating consequences. There is a need to understand risk factors for Long COVID-19 to give impetus to the development of targeted yet holistic clinical and public health interventions to reduce its associated healthcare and economic burden. Given the large number and variety of predictors implicated spanning health-related and sociodemographic factors, machine learning becomes a valuable tool. As such, this study aims to employ machine learning to produce an algorithm to predict Long COVID-19 risk, and thereby identify key predisposing factors. Longitudinal cohort data were sourced from the UK’s “Understanding Society: COVID-19 Study” (n = 601 participants with past symptomatic COVID-19 infection confirmed by serology testing). The random forest classification algorithm demonstrated good overall performance with 97.4% sensitivity and modest specificity (65.4%). Significant risk factors included early timing of acute COVID-19 infection in the pandemic, greater number of hours worked per week, older age and financial insecurity. Loneliness and having uncommon health conditions were associated with lower risk. Sensitivity analysis suggested that COVID-19 vaccination is also associated with lower risk, and asthma with an increased risk. The results are discussed with emphasis on evaluating the value of machine learning; potential clinical utility; and some benefits and limitations of machine learning for health science researchers given its availability in commonly used statistical software. Full article

X-linked adrenoleukodystrophy (ALD) is a rare metabolic disorder. Symptoms range from cerebral demyelination (cALD) to adrenal insufficiency and slowly progressive myeloneuropathy. cALD is fatal if not treated with hematopoietic cell transplantation in the early stages of the disease course. This can be achieved through cascade testing or newborn screening (NBS). Due to the lack of predictive measures of disease trajectory, patients are monitored with frequent MRI scans and hormone testing to ensure timely intervention. With this study, we wanted to explore how the diagnosis of ALD, before the development of cALD, and the follow-up program affected patients and their parents. Using semi-structured interviews, we interviewed seven parents of children with ALD aged 3–11 and four patients with ALD aged 18–25. Because NBS for ALD has not been implemented in Denmark, the patients were identified through either cascade testing or after having presented with adrenal insufficiency. We generated five themes: (I) ALD patients maintained mental resilience despite diagnosis and surveillance; (II) patients’ concerns matured with age and centered around situations that confronted them with their patient status; (III) parents of children with ALD had both short-term and long-term worries for their children’s health; (IV) parents took on a huge psychological burden; and (V) due to its rarity, the diagnosis of ALD evoked a sense of isolation and disease-related loneliness. Overall, we found a large discrepancy in the experiences reported by parents and patients. Despite the small sample size, we identified patterns that suggest that while the early diagnosis took a significant psychological toll on the parents, patients lived relatively carefree lives despite their ALD diagnosis. Full article

Background: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disorder with a significant impact on the quality of life of affected patients. This study aimed to correlate serum inflammatory markers with specific tools assessing quality of life, emotional well-being, and loneliness, such as the Dermatology Life Quality Index (DLQI), Hospital Anxiety and Depression Scale (HADS), and the UCLA Loneliness Scale. Methods: A pilot observational study including 37 patients with HS was conducted. Inflammatory serum markers, including C-reactive protein (CRP) and Erythrocyte Sedimentation Rate (ESR), were evaluated at baseline, 3 months, and 6 months later. Psychometric scores were also evaluated at the same study intervals. Results: DLQI was correlated with ESR at baseline (Spearman’s rho = 0.35, p = 0.03), indicating that poorer quality of life is associated with changes in this serum marker. Disease activity, as reflected by inflammatory markers, was associated with significant psychological burden. Specifically, a worse DLQI score was associated with higher ESR (estimate β = 0.14, 95% confidence interval [CI]: 0.05–0.22; p = 0.001) and higher CRP level (estimate β = 0.25, 95% CI: 0.02–0.48; p = 0.02). Similarly, a worse UCLA score was associated with higher ESR (estimate β = 0.11, 95% CI: 0.02–0.20, p = 0.01). Conclusions: Our study results underline the close relation between systemic inflammatory markers and clinical severity together with psychological burden in HS patients, as indicated by the significant association that was revealed between ESR/CRP and poorer psychometric scores. However, further research is warranted to validate these findings. Full article

This research addresses the rapid aging phenomenon prevalent in Asian societies, which has led to a significant increase in elderly individuals relocating to nursing homes due to health-related issues. This trend has resulted in social isolation and loneliness among the elderly, contributing to physical and mental ailments such as hypertension and cardiovascular diseases, as highlighted by the World Health Organization (WHO). To mitigate these issues, the research proposes leveraging technology, specifically the integration of robotics, to alleviate the caregiver shortage and enhance human interaction for the elderly. The novel approach involves developing a social robot designed to bridge the gap between humans and machines, combining knowledge from embedded systems, robotics, and essential soft skills for effective interaction. The authors found that this technological solution holds promise in addressing the caregiver shortage and improving the well-being of elderly individuals by reducing their sense of isolation, fostering better mental and physical health outcomes, and potentially transforming the landscape of elderly care through innovative technological applications. Future work includes expanding pilot studies and collaborating with healthcare institutions to further validate the effectiveness of the solution. Full article

Background and Objectives: The impact of coronavirus disease 2019 (COVID-19) goes beyond the consequences of the infectious disease, especially as the measures taken to prevent the spread of the virus have had a very profound impact on people’s social relationships and everyday lives. Several studies have investigated these effects, but there is a lack of longitudinal studies in Central Europe. Objective: The aim of our study was to observe changes in well-being, loneliness, and suicidal behaviour before, during, and after the COVID-19 pandemic using the same population-based cohort. Materials and Methods: A representative sample of 440 participants completed online questionnaires at four time points: 2019 (wave 0), 2021 (wave 1), 2022 (wave 2), and 2023 (wave 3). Results: The results show significant changes in the levels of well-being and loneliness over these periods. In particular, both social and emotional loneliness increased during the pandemic, while emotional loneliness increased to a greater extent without further decreases. Well-being appeared to increase after pandemic-related restrictions diminished but decreased again one year later. No significant changes concerning suicidal ideation were observed. Conclusions: Our study suggests that the COVID-19 pandemic changed the way in which people perceive their well-being and especially their relationships with others. From the data, we can conclude that people’s worldview is now lonelier than before the pandemic. Full article

Pompe disease (PD) is a rare metabolic disorder with progressive neuromuscular consequences that negatively impact a child’s development and quality of life (QoL). Despite an improved prognosis with treatment, the risk for early death due cardiorespiratory crisis remains. Parents not only face physical fatigue and family distress in coping with the child’s special needs but also experience emotions, worries, and unexpressed needs (a “humanistic burden”) that require supportive interventions. Fourteen parents of children with PD completed an online self-report questionnaire assessing their child’s QoL, their own parental burden of care, and disease-related issues. The aim was to estimate the associations between the child’s QoL and the caregiver’s burden levels. Three mothers were also interviewed. A total of 57.1% of parents lived with moderate/severe burden conditions; worse QoL for the child was associated with higher levels of caregiver burden (r_S[N = 14] = −0.67, p < 0.01). Uncertainty about the child’s future was a state commonly described by mothers. However, the child’s resilience, normalization of disease, and coping strategies (primarily positive appraisal and focusing on the present) alleviated suffering and helped mothers maintain family functioning. Finally, dissatisfaction with communication in relationships with professionals emerged. In conclusion, a typical pediatric palliative care approach is recommended since it manages to guarantee parents empathetic and supportive communication from healthcare professionals, alleviating feelings of isolation and loneliness in parents. Full article

Alzheimer’s disease (AD)—the most common cause of dementia in the elderly—is characterized by progressive memory loss and β-amyloid protein (Aβ) accumulation in the brain. Recently, loneliness was found to be a high risk factor for AD, and social isolation has become a major cause of AD. AD. Oxytocin (OXT), the main hormone involved in social bonding, has been implicated in social interactions, notably in building trust and relationships. Moreover, social isolation or social enrichment modulates the activation of neurons related to OXT. Recently, we reported that OXT reverses learning and memory impairment in AD animal models. Based on the limited number of studies currently available, OXT might be a therapeutic target for AD. Further studies are necessary in order to better understand the role of oxytocin in AD. In this review, we described the relationships between OXT, AD, and social interaction. Full article