Search Results (3)

In this study, three different detox drinks were examined for their effects on the surface roughness, colour change (∆E₀₀), and transparency parameters (∆TP₀₀) of universal resin composites. One hundred twenty samples were prepared, thirty each of universal resin composites (Omnichroma, OptiShade, Filtek Ultimate Universal, and Essentia Universal). Initial values were measured. The samples were randomly divided into three subgroups and exposed to the detox drinks. Measurements were repeated after 7, 14, and 28 days of exposure to detox drinks. The highest average surface roughness values in detox drinks were obtained with Essentia Universal. It was found that average surface roughness values increased over time, and there was a significant difference between the average surface roughness values obtained during the measurement periods (p < 0.05). In all detox drinks, the lowest ∆E₀₀ values were obtained on days 7 and 14 with OM, while the highest ∆E₀₀ values were obtained on day 28. There was a significant difference in the ∆E₀₀ values of the universal resin composites tested at each time point (p < 0.05). The highest ∆TP₀₀ values were obtained from OM in all periods and all detox drinks, while the lowest ∆TP₀₀ values were obtained from FU. When the effects of resin composites, detox drinks, and time on ∆TP₀₀ were analysed, a statistically significant difference was found (p < 0.05). Manufacturers recommend using detox drinks for 28 days. However, this period of use may affect the surface properties of restorative materials. Based on these data, we recommend careful use of detox drinks to prevent adverse effects on restorative materials. Full article

This study examined the efficacy of curcumin (Cur) against lead (Pb)-induced oxidative damage, inflammation, and cholinergic dysfunction. Institute for Cancer Research (ICR) mice received Pb (II) acetate in drinking water (1%) with or without Cur via oral gavage. Blood and brain tissues were collected for investigation. Pb increased the inflammatory markers and oxidative parameters, which were ameliorated by Cur administration. Cur treatment also improved memory loss, learning deficit, and cholinergic dysfunction via elevating acetylcholinesterase (AChE) enzymatic activity and protein expression. In silico molecular docking supported the results; Cur had a potent binding affinity for AChE receptors, tumor necrosis factor-α (TNF-α), cyclooxygenase-2 (COX-2), phosphorylations of IκB kinase (IKK), extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase (p38). According to the chemical absorption, distribution, metabolism, excretion, and toxicity (ADMET) profile, Cur could serve as a potential candidate for Pb detoxication substance via exerting antioxidant activity. Taken together, our results suggest that Cur is a natural compound that could be used for the treatment of neurodegenerative disorders via suppressing lead-induced neurotoxicity. Full article

Cadmium (Cd) contamination in food is a problem endangering human health. Cd detoxication is an interesting topic particularly using food which provides no side effects. Ricegrass juice is a squeezed juice from young rice leaves which is introduced as a functional drink rich in polyphenol components. Se-enrichment into ricegrass is initiated to provide extra advantages of their functional properties. The protective role of ricegrass juice (RG) and Se-enriched ricegrass juice (Se-RG) against Cd toxicity during pre-, co- and post-treatment on HEK293 kidney cells were investigated. Results confirmed that RG and Se-RG had very low toxicity for kidney cells. Both extracts showed a protective role during pre-treatment and co-treatment against Cd toxicity by exerting a reduction in malondialdehyde (MDA) content and the percentage of DNA damage in tail and tail length of the comets over the Cd-treated cells. However, the Se-RG indicated additional benefits in all properties over RG. High Se content in Se-RG resulted in more protective effects of the regular ricegrass juice. In summary, this study provides clear evidence that Se-enriched ricegrass juice has potential to be developed as a functional food to protect the human body from Cd contamination via the reduction of oxidative stress and DNA damage. Full article