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Keywords = calyciphyllines Q–S

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Article
Five New Alkaloids from the Stem Bark of Daphniphyllum macropodum
by Yunyang Lu, Kai Gao, Xiaoyang Wang, Wei Zhang, Ning Ma and Haifeng Tang
Molecules 2014, 19(3), 3055-3067; https://doi.org/10.3390/molecules19033055 - 10 Mar 2014
Cited by 16 | Viewed by 8707
Abstract
Five new alkaloids, daphnicyclidins M and N (compounds 1 and 2) and calyciphyllines Q–S (compounds 35), along with four known ones, paxiphylline C (6), macropodumine B (7), macropodumine C (8) and daphnicyclidin A [...] Read more.
Five new alkaloids, daphnicyclidins M and N (compounds 1 and 2) and calyciphyllines Q–S (compounds 35), along with four known ones, paxiphylline C (6), macropodumine B (7), macropodumine C (8) and daphnicyclidin A (9) were isolated from the stem bark of Daphniphyllum macropodum. Calyciphylline Q (3) is the first calyciphylline A derivative possessing a double bond between C-18 and C-19. Their structures and relative configurations were elucidated on the basis of spectroscopic methods, especially 2D NMR techniques. Compounds 1, 2, 8 and 9 exhibited cytotoxic activity against P-388 cells with IC50 values of 5.7, 6.5, 10.3 and 13.8 µM, respectively. Compounds 1 and 2 also showed cytotoxic activity against SGC-7901 cells with IC50 values of 22.4 and 25.6 µM. Full article
(This article belongs to the Collection Bioactive Compounds)
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