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Keywords = bisdemethoxycurcumin analog

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11 pages, 1451 KB  
Article
Photodynamic Agents of Synthetic Curcuminoids with Antibacterial and Anticancer Activities
by Sung-Jen Hung, Lo-Yun Chiang, Yi-An Hong, Kai-Chih Chang, Yang-Je Cheng, Hsin-Ying Wu, Hussana Hamid, Anren Hu, Tzenge-Lien Shih and Hao-Ping Chen
Organics 2026, 7(1), 1; https://doi.org/10.3390/org7010001 - 23 Dec 2025
Viewed by 1171
Abstract
Our previous study demonstrated that thiophene-substituted synthetic curcumin analogs possessed better antibacterial activity and stability than natural curcumin, demethoxycurcumin, or bisdemethoxycurcumin in antibacterial photodynamic therapy (aPDT). In addition, the activity of the furan-substituted analogs was weaker than that of the thiophene-substituted compounds. As [...] Read more.
Our previous study demonstrated that thiophene-substituted synthetic curcumin analogs possessed better antibacterial activity and stability than natural curcumin, demethoxycurcumin, or bisdemethoxycurcumin in antibacterial photodynamic therapy (aPDT). In addition, the activity of the furan-substituted analogs was weaker than that of the thiophene-substituted compounds. As oxygen, sulfur, and selenium belong to the same group in the periodic table, the antibacterial and anticancer activities of these three different elemental analogs were compared and investigated. The thiophene-substituted analog (compound 3) exhibited the most potent antibacterial activity in aPDT experiments. However, the furan-substituted analog (compound 1) exhibited the most potent anticancer activity. These results indicate that the differences in atomic radii or energy levels in these compounds produce different cell-attack results on generated free radicals. Ruthenium(II) complexes have a good reputation for use in PDT for cancer treatment. Our results show that complexation of ruthenium(II) with thiophene-substituted curcumin analogs does not enhance their antibacterial or anticancer activity. Full article
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18 pages, 7513 KB  
Article
Fabrication of Curcumin-Based Electrochemical Nanosensors for the Detection of Environmental Pollutants: 1,4-Dioxane and Hydrazine
by Renjith Kumar Rasal, Iffath Badsha, Muthaiah Shellaiah, Kumaran Subramanian, Abinaya Gayathri, Abdurahman Hajinur Hirad, Kumaravel Kaliaperumal and Thiyagarajan Devasena
Biosensors 2024, 14(6), 291; https://doi.org/10.3390/bios14060291 - 4 Jun 2024
Cited by 24 | Viewed by 3819
Abstract
This work reports the development of novel curcuminoid-based electrochemical sensors for the detection of environmental pollutants from water. In this study, the first set of electrochemical experiments was carried out using curcumin-conjugated multi-walled carbon nanotubes (MWCNT–CM) for 1,4-dioxane detection. The MWCNT–CM/GCE showed good [...] Read more.
This work reports the development of novel curcuminoid-based electrochemical sensors for the detection of environmental pollutants from water. In this study, the first set of electrochemical experiments was carried out using curcumin-conjugated multi-walled carbon nanotubes (MWCNT–CM) for 1,4-dioxane detection. The MWCNT–CM/GCE showed good sensitivity (103.25 nA nM−1 cm−2 in the linear range 1 nM to 1 µM), with LOD of 35.71 pM and LOQ of 108.21 pM. The second set of electrochemical experiments was carried out with bisdemethoxy curcumin analog quantum dots (BDMCAQD) for hydrazine detection. The BDMCAQD/GCE exhibited good sensitivity (74.96 nA nM−1 cm−2 in the linear range 100 nM to 1 µM), with LOD of 10 nM and LOQ of 44.93 nM. Thus, this work will serve as a reference for the fabrication of metal-free electrochemical sensors using curcuminoids as the redox mediator for the enhanced detection of environmental pollutants. Full article
(This article belongs to the Special Issue Electrochemical Sensors and Biosensors for Environmental, Health, and Food Safety Applications (Volume II))
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12 pages, 1677 KB  
Article
Efficient Photodynamic Killing of Gram-Positive Bacteria by Synthetic Curcuminoids
by Sung-Jen Hung, Yi-An Hong, Kai-Yu Lin, Yi-Wen Hua, Chia-Jou Kuo, Anren Hu, Tzenge-Lien Shih and Hao-Ping Chen
Int. J. Mol. Sci. 2020, 21(23), 9024; https://doi.org/10.3390/ijms21239024 - 27 Nov 2020
Cited by 13 | Viewed by 3623
Abstract
In our previous study, we have demonstrated that curcumin can efficiently kill the anaerobic bacterium Propionibacterium acnes by irradiation with low-dose blue light. The curcuminoids present in natural plant turmeric mainly include curcumin, demethoxycurcumin, and bisdemethoxycurcumin. However, only curcumin is commercially available. Eighteen [...] Read more.
In our previous study, we have demonstrated that curcumin can efficiently kill the anaerobic bacterium Propionibacterium acnes by irradiation with low-dose blue light. The curcuminoids present in natural plant turmeric mainly include curcumin, demethoxycurcumin, and bisdemethoxycurcumin. However, only curcumin is commercially available. Eighteen different curcumin analogs, including demethoxycurcumin and bisdemethoxycurcumin, were synthesized in this study. Their antibacterial activity against Gram-positive aerobic bacteria Staphylococcus aureus and Staphylococcus epidermidis was investigated using the photodynamic inactivation method. Among the three compounds in turmeric, curcumin activity is the weakest, and bisdemethoxycurcumin possesses the strongest activity. However, two synthetic compounds, (1E,6E)-1,7-bis(5-methylthiophen-2-yl)hepta-1,6-diene-3,5-dione and (1E,6E)-1,7-di(thiophen-2-yl)hepta-1,6-diene-3,5-dione, possess the best antibacterial activity among all compounds examined in this study. Their chemical stability is also better than that of bisdemethoxycurcumin, and thus has potential for future clinical applications. Full article
(This article belongs to the Special Issue Antimicrobial Materials with Medical Applications)
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10 pages, 1738 KB  
Article
The Mechanism of Bisdemethoxycurcumin Enhances Conventional Antibiotics against Methicillin-Resistant Staphylococcus aureus
by Shu Wang, Min-Chul Kim, Ok-Hwa Kang and Dong-Yeul Kwon
Int. J. Mol. Sci. 2020, 21(21), 7945; https://doi.org/10.3390/ijms21217945 - 26 Oct 2020
Cited by 21 | Viewed by 3595
Abstract
Methicillin-resistant Staphylococcus aureus (MRSA) infection has posed a serious threat to public health, therefore, the development of new antibacterial drugs is imperative. Bisdemethoxycurcumin (BDMC) is a curcumin analog that exists in nature and possesses extensive pharmacological actions. This review focuses on investigating the [...] Read more.
Methicillin-resistant Staphylococcus aureus (MRSA) infection has posed a serious threat to public health, therefore, the development of new antibacterial drugs is imperative. Bisdemethoxycurcumin (BDMC) is a curcumin analog that exists in nature and possesses extensive pharmacological actions. This review focuses on investigating the antibacterial activity of BDMC alone or in combination with three antibiotics against MRSA. We determined the minimal inhibitory concentration of BDMC, with a broth microdilution assay, and the value against all six strains was 7.8 μg/mL. The synergistic effect of BDMC combined with the antibiotics was determined using a checkerboard dilution test and a time–kill curve assay. The results showed that the antimicrobial effect of BDMC combined with antibiotics was superior to treatment with that of a single agent alone. We examined the antibacterial activity of BDMC in the presence of a membrane-permeabilizing agent and an ATPase-inhibiting agent, respectively. In addition, we analyzed the mecA transcription gene and the penicillin-binding protein 2a (PBP2a) level of MRSA treated with BDMC by quantitative RT-PCR or Western blot assay. The gene transcription and the protein level were significantly inhibited. This study demonstrated that BDMC has potent antibacterial activity, and proved that BDMC may be a potential natural modulator of antibiotics. Full article
(This article belongs to the Special Issue Antimicrobial Resistance, Molecular Mechanisms and Fight Strategies)
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