Search Results (6)

Autonomic nervous system (ANS) activity may be associated with dental anxiety; however, no studies exist on the topic. The aim of this study was to assess if ANS activity and dental anxiety are associated. Data were collected as part of a Northern Finland Birth Cohort Study, NFBC1966, at the age of 46 years with eligible data on 1905 participants. Dental anxiety was measured using the Modified Dental Anxiety Scale (MDAS) categorized as follows: 19–25 = high, 10–18 = moderate, 5–9 = no to low dental anxiety. Heart rate variability (HRV) data were collected using an HR monitor and a standard lead-II electrocardiogram (ECG). Baroreflex sensitivity (BRS) was calculated from continuous ECG and blood pressure signals. Participants were categorized into three groups as follows: Low = the lowest 20th percentile, Mid = medium 21–79th percentile, and High = the highest 20th percentile according to their ANS variables. The associations between the MDAS and ANS activity parameters were evaluated using unordered multinomial logit models adjusted for comorbidities, β-blockers, BMI, smoking, and education. High heart rate, reduced HRV, low cardiac vagal modulation, and poor BRS were associated with moderate dental anxiety, and high cardiac vagal modulation and good BRS were associated with no to low dental anxiety. Poorer ANS activity might predispose some to dental anxiety, and better ANS activity might protect from dental anxiety. Full article

Under climate change, animal breeding faces severe nutritional challenges, exhibiting their resilience and efficiency to survive and produce. The animals’ robustness can be evaluated through the use and reconstitution of body reserves (BR). This study investigated the dynamics of ewes’ BR, measured through body weight (BW) and the body condition score (BCS), and their effect on production performances of 480 ewes belonging to fat-tailed Barbarine (BB) and thin-tailed Queue Fine de l’Ouest (QFO) ewes over two consecutive years. The BW and BCS were recorded across physiological stages. Reproductive parameters and lambs’ growth were calculated. For both years and breeds, the decrease in the BCS between mating and lambing showed BR mobilization to balance nutritional restrictions, which continues until suckling; after weaning, a BR accretion was noted. The lambs’ birth weight was similar regardless of the dams’ BCS at lambing, though it was lower in the second year (3.5 vs. 4 kg). Lambs’ growth parameters depended on ewes’ BCS at lambing and weaning. Fertility rates changed with BCS changes and the higher values (80%) were recorded for ewes with BCSs between 2 and 2.5. However, prolificacy was similar for both breeds and years (p > 0.05). In conclusion, ewes have developed adaptative capacities through BR mobilization to cope with environmental challenges and successfully rear their offspring. To maintain a high offspring growth rate, it is recommended to plan correct flock nutrition during suckling. Full article

New social conditions and progress in ART have both contributed to the delay in parenthood in developed countries. While the effects of maternal age have been widely studied, paternal age is poorly understood, and there are no specific guides on ART techniques to treat its deleterious effects. It is known that there is an increase in sperm DNA fragmentation (SDF) in elderly men, and new sperm selection devices using microfluids have been developed. This study analyses 189 ICSI cycles with donor oocytes performed between January 2018 and February 2022. Spermatozoa were selected using an MSS device or density gradients, followed by ICSI fertilization and fresh/thawed embryo transfer. We assessed the association between the selection technique, paternal age (< or ≥45) and reproductive outcomes. Fertilization (FR), blastulation (BR), implantation (IR), live-birth (LBR) and miscarriage (MR) rates were calculated. The results showed significantly higher IR (57.7% vs. 42.5%) and LBR (42.9% vs. 30.3%) when applying MSS selection, and particularly higher BR, IR and LBR when the paternal age was equal to or over 45 years (BR: 64.4 ± 23% vs. 50.1 ± 25%, IR: 51.5% vs. 31.6% and LBR: 42.4% vs. 23.7%). We also found a negative correlation between BR and paternal age (r2 = 0.084). The findings show that MSS enhances success in assisted reproduction cycles with ICSI, especially in couples with advanced paternal age. We propose advanced paternal age as a new indicator for the application of sperm selection techniques that reduce fragmentation. Full article

Owing to low birth rate, the demographic dividend in China is disappearing. It is thus of great significance to study the regional differences and influencing factors of the birth rate, further proposing political advices on how to raise birth rate. In this study, 31 administrative units in China were chosen as the regional targets, and the nonlinear effects of house prices and financial expenditure on birth rate were extensively investigated by using a dynamic panel threshold model. A dynamic panel threshold model with disposable income as threshold variable, house price as independent variable, financial expenditure that concluding education funds and social security as variables influenced by threshold variable was established, which can effectively handle regional heterogeneity and endogeneity problems. The results show that the effect of financial expenditure on birth rate is complex, exhibiting a “S” shape for education funds and an inverted “U” shape for social security. Previous controversial conclusions on the impact of financial expenditure on birth rate in the literature can thereby be reasonably explained. It shows that birth rate is influenced by the lagged birth rate and house prices have negative effects on birth rate. The rationality of the present results has been verified by using consumption and input-output economic theories. Based on the empirical investigation, specific suggestions have been proposed in order to acquire sustainable development of population. Full article

Bioelectronics, an emerging discipline formed by the biology and electronic information disciplines, has maintained a state of rapid development since its birth. Amongst the various functional bioelectronics materials, bacteriorhodopsin (bR), with its directional proton pump function and favorable structural stability properties, has drawn wide attention. The main contents of the paper are as follows: Inspired by the capacitive properties of natural protoplast cell membranes, a new bio-capacitor based on bR and artificial nanochannels was constructed. As a point of innovation, microfluidic chips were integrated into our device as an ion transport channel, which made the bio-capacitor more stable. Meanwhile, a single nanopore structure was integrated to improve the accuracy of the device structure. Experiments observed that the size of the nanopore affected the ion transmission rate. Consequently, by making the single nanopore’s size change, the photocurrent duration time (PDT) of bR was effectively regulated. By using this specific phenomenon, the original transient photocurrent was successfully transformed into a square-like wave. Full article

As part of the New Hampshire Birth Cohort Study, children 3 to 5 years of age participated in a personal PM_2.5 exposure study. This paper characterizes the personal PM_2.5 exposure and protocol compliance measured with a wearable sensor. The MicroPEM™ collected personal continuous and integrated measures of PM_2.5 exposure and compliance data on 272 children. PM_2.5, black carbon (BC), and brown carbon tobacco smoke (BrC-ETS) exposure was measured from the filters. We performed a multivariate analysis of woodstove presence and other factors that influenced PM_2.5, BC, and BrC exposures. We collected valid exposure data from 258 of the 272 participants (95%). Children wore the MicroPEM for an average of 46% of the 72-h period, and over 80% for a 2-day, 1-night period (with sleep hours counted as non-compliance for this study). Elevated PM_2.5 exposures occurred in the morning, evening, and overnight. Median PM_2.5, BC, and BrC-ETS concentrations were 8.1 μg/m³, 3.6 μg/m³, and 2.4 μg/m³. The combined BC and BrC-ETS mass comprised 72% of the PM_2.5. Woodstove presence, hours used per day, and the primary heating source were associated with the children’s PM_2.5 exposure and air filters were associated with reduced PM_2.5 concentrations. Our findings suggest that woodstove smoke contributed significantly to this cohort’s PM_2.5 exposure. The high sample validity and compliance rate demonstrated that the MicroPEM can be worn by young children in epidemiologic studies to measure their PM_2.5 exposure, inform interventions to reduce the exposures, and improve children’s health. Full article