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Keywords = baroenzymology

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27 pages, 868 KB  
Review
Pre-Molten, Wet, and Dry Molten Globules en Route to the Functional State of Proteins
by Munishwar Nath Gupta and Vladimir N. Uversky
Int. J. Mol. Sci. 2023, 24(3), 2424; https://doi.org/10.3390/ijms24032424 - 26 Jan 2023
Cited by 28 | Viewed by 4505
Abstract
Transitions between the unfolded and native states of the ordered globular proteins are accompanied by the accumulation of several intermediates, such as pre-molten globules, wet molten globules, and dry molten globules. Structurally equivalent conformations can serve as native functional states of intrinsically disordered [...] Read more.
Transitions between the unfolded and native states of the ordered globular proteins are accompanied by the accumulation of several intermediates, such as pre-molten globules, wet molten globules, and dry molten globules. Structurally equivalent conformations can serve as native functional states of intrinsically disordered proteins. This overview captures the characteristics and importance of these molten globules in both structured and intrinsically disordered proteins. It also discusses examples of engineered molten globules. The formation of these intermediates under conditions of macromolecular crowding and their interactions with nanomaterials are also reviewed. Full article
(This article belongs to the Section Molecular Biophysics)
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