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20 pages, 280 KiB  
Article
Refusing Surveillance, Reframing Risk: Insights from Sex-Working Parents for Transforming Social Work
by Kimberly Fuentes
Soc. Sci. 2025, 14(7), 413; https://doi.org/10.3390/socsci14070413 - 30 Jun 2025
Viewed by 421
Abstract
Social work has long operated at the intersection of care and control—nowhere is this more apparent than in its treatment of sex-working parents. This article draws on participatory research with thirteen sex-working parents in California to examine how the child welfare system, family [...] Read more.
Social work has long operated at the intersection of care and control—nowhere is this more apparent than in its treatment of sex-working parents. This article draws on participatory research with thirteen sex-working parents in California to examine how the child welfare system, family court, and public benefit infrastructures extend punitive surveillance under the guise of support. Utilizing the framework of prison industrial complex abolition, the analysis identifies three key findings: first, family policing systems often mirror the coercive dynamics of abusive relationships that sex work helped participants to escape; second, access to social services is contingent on the performance of respectability, with compliance met not with care but with suspicion and deprivation; and third, sex-working parents enact abolitionist praxis by creating new systems of safety and stability through mutual aid when state systems fail. As social work reckons with its complicity in the carceral state, the everyday practices of sex-working parents offer a powerful blueprint for care rooted in trust, unconditional positive regard, and self-determination. Full article
20 pages, 1766 KiB  
Article
A Photovoice Study on the Lived Experiences of Youth and Mothers of Incarcerated Fathers and Husbands, Highlighting the Relevance of Abolitionist Social Work Practice
by Elizabeth K. Allen, Jason Ostrander and Kate Kelly
Soc. Sci. 2025, 14(7), 411; https://doi.org/10.3390/socsci14070411 - 29 Jun 2025
Viewed by 314
Abstract
This community-based participatory research (CBPR) study explored, using a Photovoice methodology, the lived expeiences of northeastern Black and/or African American youth and mothers who were currently experiencing the incarceration of their fathers and husbands. Grounded in critical theories of dual consciousness and comparative [...] Read more.
This community-based participatory research (CBPR) study explored, using a Photovoice methodology, the lived expeiences of northeastern Black and/or African American youth and mothers who were currently experiencing the incarceration of their fathers and husbands. Grounded in critical theories of dual consciousness and comparative conflict, the findings provide valuable insights into how this population navigates the intersections of family, school, and community within the context of the criminal legal system, and, in the process, underscore the relevance of Abolitionist practice in capturing their theoretically lived experiences. Participants documented through photography and narrative reflections the multifaceted impacts of incarceration on fathers and husbands, including disrupted family dynamics, social stigma, and barriers to community resources. A focus group with the mothers of these youth highlighted the profound impact of incarceration on their family structure, revealing significant emotional burdens for caregivers as well as personal changes to parenting styles as a result of this project. A central theme that emerged was the development of a “double” or “dual consciousness”—an ability to see humanity and injustice in their circumstances, fueling a desire for systemic change. Overall, this CBPR project amplifies the voices of marginalized youth and mothers, illuminating how the criminal legal system perpetuates cycles of trauma, stigma, and disempowerment. The implications call for a radical reimagining of the role of social work in creating more equitable, restorative, and healing-centered communities, including an immediate embrace of Abolitionist practice concepts and interventions. Full article
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27 pages, 1242 KiB  
Article
Implications of Battery and Gas Storage for Germany’s National Energy Management with Increasing Volatile Energy Sources
by Joachim Dengler and Björn Peters
Sustainability 2025, 17(12), 5295; https://doi.org/10.3390/su17125295 - 8 Jun 2025
Viewed by 2920
Abstract
Weather-dependent, volatile energy sources, such as wind power and solar photovoltaics (PV), contribute considerably to the German electric energy supply. The current German government aims to substantially increase their market share. Using high-resolution time-series data from energy production and demand measurements, we replicate [...] Read more.
Weather-dependent, volatile energy sources, such as wind power and solar photovoltaics (PV), contribute considerably to the German electric energy supply. The current German government aims to substantially increase their market share. Using high-resolution time-series data from energy production and demand measurements, we replicate and analyze scenarios from the “Klimaneutrales Deutschland 2045” (KND2045) study. KND2045 was the basis for the German Government’s 2021 decision to move the abolition of CO2 emissions from 2050 to 2045. The primary question in KND2045 is whether security of supply can be maintained by relying primarily on an effective duopoly of wind and solar power. We simulate scenarios for 2023, 2030, and 2045 using 15-min time-resolved measurements of wind and solar energy production and demand from 2023 and 2024, incorporating battery and gas storage systems into our model. We assess the overall economic costs for these scenarios. Our calculations demonstrate that the KND2045 scenarios are infeasible, as significant supply gaps persist during dark wind lulls, compromising security of supply. Instead, we propose improvements to these scenarios by incorporating nuclear energy as a backup to address KND2045’s shortcomings. Full article
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18 pages, 476 KiB  
Article
Indigenous Abolition and the Third Space of Indian Child Welfare
by Theresa Ysabel Rocha Beardall
Genealogy 2025, 9(2), 59; https://doi.org/10.3390/genealogy9020059 - 31 May 2025
Viewed by 1134
Abstract
This article introduces the Third Space of Indian child welfare to theorize how Indigenous nations simultaneously engage and disrupt settler legal systems while building sovereign, care-based alternatives. Drawing from legal analysis, Indigenous political thought, and sociohistorical synthesis, I trace the historical continuity from [...] Read more.
This article introduces the Third Space of Indian child welfare to theorize how Indigenous nations simultaneously engage and disrupt settler legal systems while building sovereign, care-based alternatives. Drawing from legal analysis, Indigenous political thought, and sociohistorical synthesis, I trace the historical continuity from boarding schools to today’s foster care removals, showing how child welfare operates as a colonial apparatus of family separation. In response, Native nations enact governance through three interrelated strategies: strategic legal engagement, kinship-based care, and tribally controlled family collectives. Building on Bruyneel’s theory of third space sovereignty, Simpson’s nested sovereignty, and Lightfoot’s global Indigenous rights framework, I conceptualize the Third Space as a dynamic field of Indigenous governance that transcends binary settler logics. These practices constitute sovereign abolitionist praxis. They reclaim kinship, resist carceral systems, and build collective futures beyond settler rule. Thus, rather than treating the Indian Child Welfare Act (ICWA) as a federal safeguard, I argue that tribes have repurposed ICWA as a legal and political vehicle for relational governance. This reframing challenges dominant crisis-based narratives and positions Indigenous child welfare as the center of a “global Indigenous politics of care” with implications for theories of sovereignty, family, and abolitionist futures across disciplines, geographies, and social groups. The article concludes by reflecting on the broader implications of the Third Space for other Indigenous and minoritized communities navigating state control and asserting self-determined care. Full article
(This article belongs to the Special Issue Self Determination in First Peoples Child Protection)
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17 pages, 10050 KiB  
Article
Loess Plateau Cropland: Evolution and Ecological Impacts over Four Millennia
by Tao Huang, Shaoshan An, Wanyun Huang and Baoyuan Liu
Land 2025, 14(5), 1015; https://doi.org/10.3390/land14051015 - 7 May 2025
Viewed by 481
Abstract
The Loess Plateau (LP), the cradle of Chinese civilization, has a long history of agricultural activities closely linked to ecological changes. This study addresses a fundamental question: what was the maximum sustainable cropland area threshold for the LP prior to modern soil and [...] Read more.
The Loess Plateau (LP), the cradle of Chinese civilization, has a long history of agricultural activities closely linked to ecological changes. This study addresses a fundamental question: what was the maximum sustainable cropland area threshold for the LP prior to modern soil and water conservation measures? To answer this, we analyzed the historical data to investigate changes in the cropland area and their ecological impacts over the past 4000 years, with the specific aim of examining the long-term interactions between land exploitation and the ecosystem that defined sustainable thresholds. Three key stages of cropland area development were identified: slow growth (2000–500 BC), a fluctuating phase (500 BC–1000 AD), and rapid expansion (1000–2000 AD). During the slow-growth and rapid-expansion stages, the cropland areas were estimated at 34.9 ± 23.4 and 117.9 ± 34.1 thousand km2, with growth rates of 2.9 and 8.7 thousand km2/100 years, respectively, while the fluctuating period stabilized at 62.1 ± 18.1 thousand km2. Population growth was the primary driver of cropland expansion (56.9%), followed by agricultural technology and policy adjustments (27%) and climate change (16.1%). Particularly over the past 1000 years, climate deterioration and a population surge due to the abolition of the poll tax accelerated cropland expansion, resulting in deforestation, intensified soil erosion specific to the LP, and frequent flooding of the lower Yellow River (YR). In contrast, during the fluctuating period, rapid social development did not lead to major ecological issues, suggesting that moderate cropland expansion can balance social development and ecological sustainability. Based on the historical conditions, without modern soil and water conservation measures, this study determined that the upper limit of the cropland area during the fluctuating period (80.2 thousand km2) is the maximum sustainable cropland area for the LP, establishing a scientific basis to guide future land-use strategies. Especially in the face of population pressure and climate deterioration, developing agriculture and adjusting policies to increase grain production will be essential to balance the ecological risks and maintenance of food security while remaining within this threshold. These findings offer insights into the agricultural history and ecological management of the LP and can serve as a reference for similar studies of other regions. Full article
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23 pages, 286 KiB  
Article
Special Prosecutor’s Offices and Their Position in a State Governed by the Rule of Law: Is the Abolition of Office of Special Prosecution in Slovakia Unconstitutional?
by Libor Klimek and Bystrík Šramel
Laws 2025, 14(2), 25; https://doi.org/10.3390/laws14020025 - 13 Apr 2025
Viewed by 1438
Abstract
The specialization of public prosecution offices has been a growing international trend, particularly in addressing complex forms of crime such as corruption, economic crime, and organized crime. Many countries have established specialized prosecution bodies to enhance the efficiency and effectiveness of law enforcement [...] Read more.
The specialization of public prosecution offices has been a growing international trend, particularly in addressing complex forms of crime such as corruption, economic crime, and organized crime. Many countries have established specialized prosecution bodies to enhance the efficiency and effectiveness of law enforcement in these areas. However, Slovakia has recently taken a different approach by abolishing its Office of the Special Prosecution, a decision that contrasts sharply with prevailing global tendencies. This paper explores the reasons behind this shift, analyzing the political and legal arguments presented by both proponents and opponents of the abolition. The paper examines whether this move aligns with the rule of law and international legal obligations and considers its potential consequences for the effectiveness of criminal justice in Slovakia. While the paper is based on legal principles and comparative methods, it acknowledges the inherently political nature of decisions concerning the structure of prosecution services. Full article
(This article belongs to the Section Criminal Justice Issues)
18 pages, 270 KiB  
Article
Disrupting the Abuse-Prison Nexus: The Gendered Violence of Prosecution and Abolitionist Feminist Approaches to Social Care Work
by Sid P. Jordan, Emily Thuma, Aylaliyah Assefa Birru, Deirdre Wilson, Romarilyn Ralston, Norma Cumpian and Joseph Hankins
Soc. Sci. 2025, 14(3), 184; https://doi.org/10.3390/socsci14030184 - 18 Mar 2025
Viewed by 826
Abstract
The vast majority of people in U.S. women’s prisons are survivors of interpersonal violence, a pattern that organizers and advocates have referred to as the abuse-to-prison pipeline. This article critically examines criminal prosecution from the perspectives of survivors of interpersonal violence who faced [...] Read more.
The vast majority of people in U.S. women’s prisons are survivors of interpersonal violence, a pattern that organizers and advocates have referred to as the abuse-to-prison pipeline. This article critically examines criminal prosecution from the perspectives of survivors of interpersonal violence who faced long prison sentences in California. In-depth interviews and group discussions were generated through a participatory process at a gathering to launch the University of California Sentencing Project, a partnership with the community-based organization California Coalition for Women Prisoners. The twenty-two formerly incarcerated participants had collectively spent more than 300 years imprisoned. Drawing on their lived experiences spanning several decades and multiple jurisdictions, this article offers an unyielding account of tactics of isolation, intimidation, narrative manipulation, and confinement as definitional to prosecutorial practice and culture. This criminalized survivor-centered analysis of prosecution shows how one of the most robustly funded public interventions for interpersonal violence is not merely failing to protect victims but is protracting patterns of abuse and coercive control. Implications are discussed in terms of social care work and collective defense rooted in abolition feminism. Full article
9 pages, 769 KiB  
Article
“To Be or Not to Be” a Conscientious Objector to Voluntary Abortion: An Italian Web-Survey of Healthcare Workers
by Carmen Imma Aquino, Libera Troìa, Maurizio Guida and Daniela Surico
Medicina 2024, 60(12), 1984; https://doi.org/10.3390/medicina60121984 - 2 Dec 2024
Cited by 1 | Viewed by 1041
Abstract
Background and Objectives: Conscientious objection to voluntary abortion remains a hot debate topic. This could affect the accessibility to pregnancy termination. Our aim is to evaluate the possible aspects related to an operators’ choice about objection for voluntary abortion, such as the [...] Read more.
Background and Objectives: Conscientious objection to voluntary abortion remains a hot debate topic. This could affect the accessibility to pregnancy termination. Our aim is to evaluate the possible aspects related to an operators’ choice about objection for voluntary abortion, such as the following: the abolition of the time limit, the instruction of a multi-collegiate commission, the introduction of pharmacological rather than surgical procedures, the fetal/maternal illness and the case of sexual violence. Materials and Methods: This is an observational, descriptive study that involves a cohort of Italian healthcare workers who answered a web-survey. Results: Of the total 352 respondents, only 20.8% affirmed to be objectors versus 79.2% of non-objectors. For the objectors, 72.2% declared that they would not change status in case of pharmacological abortion; 79.7% would not suspend their choice for interruption in the second trimester; 63.3% would suspend the objection with a multi-collegiate commission, and 69.0% would discontinue their objection in the case of sexual violence. 72.0% of the total participants declared that the abolition of the time limit could have a resecuring impact on women’s choice. Conclusions: Most operators declared that the abolition of the time limit could have beneficial effects. Among the objectors, the status would change especially with the introduction of a multi-collegiate commission, and in case of serious maternal/fetal illness and/or sexual violence. Full article
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17 pages, 316 KiB  
Review
Policing Is Reproductive Oppression: How Policing and Carceral Systems Criminalize Parenting and Maintain Reproductive Oppression
by Maya Pendleton and Alan J. Dettlaff
Soc. Sci. 2024, 13(10), 515; https://doi.org/10.3390/socsci13100515 - 28 Sep 2024
Cited by 2 | Viewed by 2227
Abstract
Since the era of chattel slavery, the state has used institutionalized abuse and violence as a tool for reproductive control. Today, public institutions and social services have been established by the state to police and surveil the behavior of poor communities and parents [...] Read more.
Since the era of chattel slavery, the state has used institutionalized abuse and violence as a tool for reproductive control. Today, public institutions and social services have been established by the state to police and surveil the behavior of poor communities and parents to maintain the reproductive violence and oppression that began centuries ago. This paper uses a reproductive justice framework to explore how the history of criminalizing pregnancy, surveilling Black and Indigenous communities, and denying reproductive autonomy are connected to and maintained by the present-day family policing system. In doing so, this paper expands on existing literature to create a stronger link and build solidarity between the movements against family policing and reproductive oppression. Full article
16 pages, 282 KiB  
Article
Sikh Diasporic Approaches in Anti-Caste Activism
by Jasleen Singh
Religions 2024, 15(8), 1013; https://doi.org/10.3390/rel15081013 - 20 Aug 2024
Cited by 1 | Viewed by 1790
Abstract
This article looks at how Sikh ethical principles are informing how Sikh diasporic activists approach contemporary social justice issues around caste abolition. The article is divided into three different sections that look at the history of castes within Punjab and the North American [...] Read more.
This article looks at how Sikh ethical principles are informing how Sikh diasporic activists approach contemporary social justice issues around caste abolition. The article is divided into three different sections that look at the history of castes within Punjab and the North American Sikh diaspora, especially in the late 19th c. but with some reference to contemporary history. Later, I utilized my interviews with Sikh activists who have supported recent legislation in Seattle and California around caste discrimination. Finally, the article discusses the work of a Sikh queer collective, a group I have worked with over a period of two years, to examine how notions of queerness and anti-caste politics within Sikh principles might be a path forward towards caste abolition. Full article
(This article belongs to the Special Issue Sikhi, Sikhs and Caste: Lived Experiences in a Global Context)
13 pages, 3748 KiB  
Article
Influence of Metamizole on Antitumour Activity of Risedronate Sodium in In Vitro Studies on Canine (D-17) and Human (U-2 OS) Osteosarcoma Cell Lines
by Dominik Poradowski, Aleksander Chrószcz, Radosław Spychaj, Joanna Wolińska and Vedat Onar
Biomedicines 2024, 12(8), 1869; https://doi.org/10.3390/biomedicines12081869 - 15 Aug 2024
Cited by 1 | Viewed by 1740
Abstract
The availability of metamizole varies greatly around the world. There are countries such as the USA, UK, or Australia where the use of metamizole is completely forbidden, and there are also countries where this drug is available only on prescription (e.g., Greece, Italy, [...] Read more.
The availability of metamizole varies greatly around the world. There are countries such as the USA, UK, or Australia where the use of metamizole is completely forbidden, and there are also countries where this drug is available only on prescription (e.g., Greece, Italy, Spain, etc.) and those in which it is sold OTC—over the counter (e.g., most Asian and South American countries). Metamizole, as a drug with a strong analgesic effect, is used as an alternative to other non-steroidal anti-inflammatory drugs, alone or in combination with opioid drugs. Risedronate sodium is a third-generation bisphosphonate commonly used in orthopaedic and metabolic diseases of the musculoskeletal system, including hypercalcemia, postmenopausal osteoporosis, Paget’s disease, etc. The aim of this study was to check whether there were any pharmacological interactions between metamizole and risedronate sodium in in vitro studies. Cell viability was assessed using the MTT method, the number of apoptotic cells was assessed using the labelling TUNEL method, and the cell cycle assessment was performed with a flow cytometer and propidium iodide. This was a pilot study, which is why only two cancer cell lines were tested: D-17 of canine osteosarcoma and U-2 OS of human osteosarcoma. Exposure of the canine osteosarcoma cell line to a combination of risedronate sodium (100 µg/mL) and metamizole (50, 5, and 0.5 µg/mL) resulted in the complete abolition of the cytoprotective activity of metamizole. In the human osteosarcoma cell line, the cytotoxic effect of risedronate sodium was entirely eliminated in the presence of 50 µg/mL of metamizole. The cytoprotective and anti-apoptotic effect of metamizole in combination with risedronate sodium in the tested human and canine osteosarcoma cell lines indicates an urgent need for further in vivo studies to confirm or disprove the potential dose-dependent undesirable effect of such a therapy. Full article
(This article belongs to the Special Issue Molecular Insights into Osteosarcoma)
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9 pages, 210 KiB  
Article
Safety and Effectiveness of Coronary Sinus Reducer in the Therapy of Refractory Angina Pectoris—Mid-Term Results of the Real-Life Cohort
by Szymon Włodarczak, Piotr Rola, Artur Jastrzębski, Karol Turkiewicz, Andrzej Korda, Piotr Włodarczak, Mateusz Barycki, Jan Jakub Kulczycki, Łukasz Furtan, Adrian Włodarczak and Maciej Lesiak
J. Clin. Med. 2024, 13(15), 4413; https://doi.org/10.3390/jcm13154413 - 28 Jul 2024
Cited by 3 | Viewed by 1862
Abstract
Background: Despite continuous improvements in revascularization techniques, refractory angina without potential revascularization options remains a relevant clinical issue with significant impact on the patient’s quality of life. Recently, a novel device, the Coronary Sinus Reducer (CSR), has been introduced into clinical practice as [...] Read more.
Background: Despite continuous improvements in revascularization techniques, refractory angina without potential revascularization options remains a relevant clinical issue with significant impact on the patient’s quality of life. Recently, a novel device, the Coronary Sinus Reducer (CSR), has been introduced into clinical practice as a therapeutic option for patients with disabling angina pectoris. In this single-center, observational study, we evaluated the mid-term (3-month) safety and efficacy of the CSR in a real-world cohort. Methods: The study population consisted of 55 patients with refractory angina without potential revascularization options, who were predominantly men (87.3%) with a high cardiovascular risk factor burden and advanced angina (baseline CCS angina class 3.15 ± 0.6). In terms of procedure safety, all patients underwent successful device deployment with only one periprocedural complication. Results: At the 3-month follow-up, we observed a statistically significant improvement in angina control measured CCS class and SAQ-7 total questionnaire along with increased abolition of physical limitation—6-MWT (233.3 ± 107.1 vs. 305.2 ± 126.8; p < 0.0001). Additionally, we observed significant improvement in terms of quality of life measurements SF-36, the EQ-5D-5L questionnaire, and the EQ-VAS. Conclusions: Our real-world data suggest that CSR implantation is a relatively safe procedure and appears to be particularly effective in relieving angina symptoms and improving quality of life in subjects with refractory angina. Full article
(This article belongs to the Special Issue Clinical Advances in Angina Pectoris)
16 pages, 2079 KiB  
Article
Vulnerability and Dependence in Slavery and Post-Slavery Societies: A Historicisation of the Enslaved Children (Pon Pekpen) from the Bamum Kingdom (West Cameroon)
by Mbohou Sylvain
Genealogy 2024, 8(3), 83; https://doi.org/10.3390/genealogy8030083 - 30 Jun 2024
Cited by 2 | Viewed by 3103
Abstract
This article is a reflection on the history of enslaved children (Pon pekpen) in African slavery and post-slavery societies, such as the Bamum Kingdom. This traditional monarchy of the Grassfields of Cameroon, founded in 1394 by Nchare Yen, was one of [...] Read more.
This article is a reflection on the history of enslaved children (Pon pekpen) in African slavery and post-slavery societies, such as the Bamum Kingdom. This traditional monarchy of the Grassfields of Cameroon, founded in 1394 by Nchare Yen, was one of the largest providers of captives transported to the Atlantic coast and used locally to meet the needs of traditional slavery. In this kingdom, slaves and their descendants, as well as enslaved peoples, represented nearly 80% of the total population. The trade of captives and servile practices left indelible traces, particularly where enslaved children were concerned. So, what did enslaved children represent in African slavery and post-slavery societies, such as the Bamum Kingdom? The aim of this study is to show that the enslaved children were the most vulnerable and dependent members of slavery and post-slavery systems. This study is based on oral, archival iconographic, written and electronic sources, using theories of social dominance and subaltern studies. It clearly shows that the vulnerability and dependence of enslaved children (Pon pekpen) made them special, weak and hopeful links in the slavery system and the persistence of slavery practices. They were mainly victims of traditional slavery and of the trans-Saharan and transatlantic slave trades. Despite the formal abolition of the slave trade and slavery between the 19th and 20th centuries, enslaved children and the descendants of enslaved people continue to be victims of a kind of subalternisation because they are usually considered second-class citizens. Full article
(This article belongs to the Special Issue Retrospectives on Child Slavery in Africa)
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17 pages, 7284 KiB  
Article
Ultrasound-Mediated Lysozyme Microbubbles Targeting NOX4 Knockdown Alleviate Cisplatin-Exposed Cochlear Hair Cell Ototoxicity
by Yuan-Yung Lin, Ai-Ho Liao, Hsiang-Tzu Li, Peng-Yi Jiang, Yi-Chun Lin, Ho-Chiao Chuang, Kuo-Hsing Ma, Hang-Kang Chen, Yi-Tsen Liu, Cheng-Ping Shih and Chih-Hung Wang
Int. J. Mol. Sci. 2024, 25(13), 7096; https://doi.org/10.3390/ijms25137096 - 28 Jun 2024
Cited by 1 | Viewed by 1884
Abstract
The nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 4 (NOX4) protein plays an essential role in the cisplatin (CDDP)-induced generation of reactive oxygen species (ROS). In this study, we evaluated the suitability of ultrasound-mediated lysozyme microbubble (USMB) cavitation to enhance NOX4 siRNA transfection in [...] Read more.
The nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 4 (NOX4) protein plays an essential role in the cisplatin (CDDP)-induced generation of reactive oxygen species (ROS). In this study, we evaluated the suitability of ultrasound-mediated lysozyme microbubble (USMB) cavitation to enhance NOX4 siRNA transfection in vitro and ex vivo. Lysozyme-shelled microbubbles (LyzMBs) were constructed and designed for siNOX4 loading as siNOX4/LyzMBs. We investigated different siNOX4-based cell transfection approaches, including naked siNOX4, LyzMB-mixed siNOX4, and siNOX4-loaded LyzMBs, and compared their silencing effects in CDDP-treated HEI-OC1 cells and mouse organ of Corti explants. Transfection efficiencies were evaluated by quantifying the cellular uptake of cyanine 3 (Cy3) fluorescein-labeled siRNA. In vitro experiments showed that the high transfection efficacy (48.18%) of siNOX4 to HEI-OC1 cells mediated by US and siNOX4-loaded LyzMBs significantly inhibited CDDP-induced ROS generation to almost the basal level. The ex vivo CDDP-treated organ of Corti explants of mice showed an even more robust silencing effect of the NOX4 gene in the siNOX4/LyzMB groups treated with US sonication than without US sonication, with a marked abolition of CDDP-induced ROS generation and cytotoxicity. Loading of siNOX4 on LyzMBs can stabilize siNOX4 and prevent its degradation, thereby enhancing the transfection and silencing effects when combined with US sonication. This USMB-derived therapy modality for alleviating CDDP-induced ototoxicity may be suitable for future clinical applications. Full article
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19 pages, 479 KiB  
Article
The Influence of Qiu Jun on Jesuit Missionaries and Chinese Christian Texts in Ming–Qing China
by Dadui Yao
Religions 2024, 15(7), 757; https://doi.org/10.3390/rel15070757 - 21 Jun 2024
Cited by 1 | Viewed by 2176
Abstract
This study explores the previously overlooked influence of Qiu Jun, a renowned mid-Ming dynasty scholar, on Jesuit missionaries and Chinese Catholic believers. Although Qiu’s impact on Confucian scholars of the mid-to-late Ming period is well established, his role in shaping formalized Chinese ritual [...] Read more.
This study explores the previously overlooked influence of Qiu Jun, a renowned mid-Ming dynasty scholar, on Jesuit missionaries and Chinese Catholic believers. Although Qiu’s impact on Confucian scholars of the mid-to-late Ming period is well established, his role in shaping formalized Chinese ritual systems and Chinese Catholicism has received little attention. A closer examination of Jesuit missionaries’ translation of Confucian classics and Chinese Catholic texts from the late Ming and early Qing periods reveals that Qiu’s works were frequently cited, particularly in relation to the abolition of divine titles, the worship of Confucius, and the establishment of the City-god system. Qiu’s responses to these issues, informed by Emperor Zhu Yuanzhang’s efforts to centralize power and establish authority in both secular and religious spheres, served as key references for mid-Ming reforms. Moreover, Jesuit fathers and Chinese Catholic adherents drew on Qiu’s perspectives in their writings to address various issues during the Chinese Rites Controversy. This research uncovers the profound impact of Qiu Jun’s ideas on the cultural exchange between China and the West in the 17th–18th centuries. Full article
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