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Sino-nasal disease is appropriately treated with topical treatment, where the nasal mucosa acts as a barrier to systemic absorption. Non-invasive nasal delivery of drugs has produced some small molecule products with good bioavailability. With the recent COVID pandemic and the need for nasal mucosal immunity becoming more appreciated, more interest has become focused on the nasal cavity for vaccine delivery. In parallel, it has been recognized that drug delivery to different parts of the nose can have different results and for “nose-to-brain” delivery, deposition on the olfactory epithelium of the upper nasal space is desirable. Here the non-motile cilia and reduced mucociliary clearance lead to longer residence time that permits enhanced absorption, either into the systemic circulation or directly into the CNS. Many of the developments in nasal delivery have been to add bioadhesives and absorption/permeation enhancers, creating more complicated formulations and development pathways, but other projects have shown that the delivery device itself may allow more differential targeting of the upper nasal space without these additions and that could allow faster and more efficient programs to bring a wider range of drugs—and vaccines—to market. Full article

The feeding characteristics of the nase, based on its mouth morphology and feeding behavior related to aquatic habitat substrata sediments make this fish a biological uptake vector for microplastics in freshwater ecosystems. Fibers may have limited absorption through the gastrointestinal tract therefore unlikely to be found in fish gastrointestinal tissue and muscle tissue. The presence of microplastic fibers in the gastrointestinal content is proof of how difficult it is for these fibers to become embedded in other organs. The absence of microplastic fibers in muscle tissue and gastrointestinal tissue is key information for microplastic fabrication and management in aquatic ecosystems. The majority of fish have relatively low levels of microplastics; however, a few individuals have a higher dose. This is true for all types of microplastics analyzed, with the exception of fish that had just one microplastic present in the analyzed matrix. The microplastics are not concentrated in the fish muscle tissue, gastrointestinal tissue and gastrointestinal content in relation to fish age, which may be due to their different mobility in the ecosystem, or due to the recent appearance of this type of contamination and the scale at which microplastics bioaccumulate. Such a relatively common fish species must be included in the assessment and monitoring systems of the Eurasian lotic systems. The risks involved include the transfer of the freshwater environments microplastics into human tissues via the food web of fishing species with the nase as a key basis. Full article