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Keywords = Vecuronuim

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16 pages, 422 KB  
Review
Sugammadex for Neuromuscular Blockade Reversal: A Narrative Review
by Sapna Ravindranath, Kevin Backfish-White, John Wolfe and Yatish S. Ranganath
J. Clin. Med. 2025, 14(12), 4128; https://doi.org/10.3390/jcm14124128 - 11 Jun 2025
Cited by 6 | Viewed by 12407
Abstract
Sugammadex represents a significant advancement in neuromuscular blockade management, enabling rapid, predictable, and highly effective reversal of steroidal neuromuscular blockers such as rocuronium and vecuronium. This review critically examines recent advances in sugammadex research, particularly over the last decade, detailing its pharmacological profile, [...] Read more.
Sugammadex represents a significant advancement in neuromuscular blockade management, enabling rapid, predictable, and highly effective reversal of steroidal neuromuscular blockers such as rocuronium and vecuronium. This review critically examines recent advances in sugammadex research, particularly over the last decade, detailing its pharmacological profile, clinical efficacy, and safety compared to traditional reversal agents, like neostigmine. Its expanding clinical applications across operating rooms, critical care units, and emergency medicine are discussed, emphasizing dosing recommendations and clinical utility in special patient populations, including individuals with renal impairment, pediatric, obstetric, and obese patients. Economic considerations are explored, highlighting sugammadex’s cost-effectiveness through reduced postoperative complications and enhanced operational efficiency, despite higher initial costs. Finally, the review outlines ongoing research directions, including emerging reversal agents, advanced neuromuscular monitoring technologies, and potential future clinical applications, underscoring sugammadex’s evolving role in improving patient safety and anesthetic practice. Full article
(This article belongs to the Special Issue General Anesthesia: Recent Developments and Emerging Trends)
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