Search Results (7)

Recent breakthroughs in materials science have driven transformative advancements in restorative dentistry. Advanced dental materials, such as bioactive materials, nanocomposites, and fibre-reinforced composites, are attracting attention. Bioactive materials, such as calcium silicate-based cements and bioactive glass, represent a paradigm shift by interacting with biological tissues to stimulate regeneration. They promote hydroxyapatite formation, accelerating mineralisation in hard and soft tissues, and are pivotal tools in minimally invasive procedures due to their functions of structural support and biological interaction. Nanomaterials, especially nanocomposites with embedded nanoparticles, effectively address polymerisation shrinkage and wear in traditional composites. With just 1.5% shrinkage, a flexural strength over 150 MPa, and 44–60% higher wear resistance than conventional composites, they offer significant improvements. Nanocomposites also provide enamel-like translucency and a bond strength of 27–38 MPa to dentin, ensuring excellent aesthetics and durability—making them ideal for direct restorations. Fibre-reinforced composites with glass or polymer fibres balance aesthetics with strength and are increasingly used in restorations. Their high fracture resistance, which closely approaches that of a natural tooth, enables clinicians to preserve more healthy teeth during restoration, in line with the principles of modern conservative dentistry. Overall, bioactive materials enhance tissue repair, nanocomposites optimise form and function, and fibre-reinforced composites deliver strength without compromising aesthetics. As these materials transition from research to clinical practice, they promise longer-lasting treatments, fewer complications, and higher patient satisfaction. This narrative review aims to explore three types of advanced dental materials and their role in improving clinical outcomes. Full article

Background: The aim of this bibliometric study was to evaluate publication trends in the most frequently cited clinical trials on the treatment of gingival recession, taking into account the augmentation materials used. Methods: A Web of Science search was performed among articles published by 30 September 2024. Two independent reviewers evaluated year of publication, journal, authorship country of authors, collaborative relationship, keywords, and the main domains. Results: The top one hundred most-cited clinical trials were published in the span of 26 years from 1993 to 2019, and the total citation counts varied from 44 to 284 (83.69 citations per paper). There was correlation between the time of publication and the number of citations. The articles were authored by 333 researchers representing twenty-two countries. Italy contributed the highest number of articles (n = 36), followed by the USA (n = 28) and Brazil (n = 17). International collaborations were predominantly observed between Italy, the USA, and Switzerland. The type of graft was the most cited field of research (34), followed by guided tissue regeneration (17) and enamel matrix derivative (13). Conclusions: The country that produced the highest number publications among the 100 most-cited clinical trials on gingival recession treatment was Italy. The use of connective tissue graft (CTG) and coronally advanced flap (CAF) was the most prominent trend. Future work should combine bibliometric mapping with critical quality appraisal and explore whether citation trends align with best available evidence. Full article

Background: Periodontal regeneration has become a focal point in modern dental therapy, aiming to restore the form and function of lost periodontal structures. A literature search was conducted on the PubMed, Scopus, and Web of Science databases, focusing on studies published between 2000 and 2025 that addressed the clinical use of dental biomaterials in periodontal regeneration. Emphasis was placed on the use of bone grafts, guided tissue regeneration (GTR) membranes, enamel matrix derivatives, scaffolds, growth factors, and stem cell-based technologies. The review also outlines the limitations of current strategies, including unpredictable clinical responses, the rapid degradation of bioactive components, and variability in healing. Emerging directions, such as nanotechnology, gene-activated matrices, and 3D-printed scaffolds, are highlighted for their potential to improve predictability and personalization in periodontal therapy. This synthesis underscores both the progress and ongoing challenges in the field, emphasizing the need for continued research into material innovation and patient-specific solutions. Full article

This systematic review aimed to evaluate the effectiveness of teriparatide (TP) in guided bone regeneration (GBR). An electronic search without language or date restrictions was performed in PubMed, Web of Science, Scopus, Scielo, and gray literature for articles published until June 2025. Inclusion criteria considered studies evaluating the effect of TP on bone regeneration, analyzed using SYRCLE’s Risk of Bias tool. Twenty-four preclinical studies were included, covering diverse craniofacial models (mandibular, calvarial, extraction sockets, sinus augmentation, distraction osteogenesis, segmental defects) and employing systemic or local TP administration. Teriparatide consistently enhanced osteogenesis, graft integration, angiogenesis, and mineralization, with potentiated effects when combined with various biomaterials, including polyethylene glycol (PEG), hydroxyapatite/tricalcium phosphate (HA/TCP), biphasic calcium phosphate (BCP), octacalcium phosphate collagen (OCP/Col), enamel matrix derivatives (EMDs), autografts, allografts, xenografts (Bio-Oss), strontium ranelate, and bioactive glass. Critically, most studies presented a moderate-to-high risk of bias, with insufficient randomization, allocation concealment, and blinding, which limited the internal validity of the findings. TP shows promising osteoanabolic potential in guided bone regeneration, enhancing bone formation, angiogenesis, and scaffold integration across preclinical models. Nonetheless, its translation to clinical practice requires well-designed human randomized controlled trials to define optimal dosing strategies, long-term safety, and its role in oral and craniomaxillofacial surgical applications. Full article

This study evaluated the structural changes of enamel treated by the Regenerate system and carbon dioxide (CO₂) laser against acid challenge. Thirty human enamel slabs were prepared and assigned into three groups: Group I: untreated (control); Group II: treated with the Regenerate system; and Group III exposed to CO₂ laser. All specimens were subjected to an acid challenge (pH 4.5–7.0) for 14 days. Specimens were evaluated and compared at 120 points using five Raman microspectroscopic peaks; the phosphate vibrations ν1, ν2, ν3, and ν4 at 960, 433, 1029, and 579 cm⁻¹, respectively, and the carbonate at 1070 cm⁻¹, followed by Vickers microhardness test. The ratio of carbonate to phosphate was correlated to the equivalent microhardness numbers. The intensities of phosphate peaks ν1, ν2, and ν4 were reduced in all groups post-acid challenge, while the carbonate and ν3 were significantly increased (p < 0.000). Surfaces treated by Regenerate exhibited higher peak intensity of phosphate and carbonate before and after pH-cycling (p < 0.05). The mineral content in enamel had a direct effect on tissue microhardness, and the CO₂-lased surfaces showed a reduced carbonate content and higher microhardness values. Both approaches induced surface changes that can protect enamel against acid challenge resulting in a significant benefit for dental healthcare. Full article

Currently, it remains unclear which specific peptides could be appropriate for applications in different fields of dentistry. The aim of this scoping review was to scan the contemporary scientific papers related to the types, uses and applications of peptides in dentistry at the moment. Literature database searches were performed in the following databases: PubMed/MEDLINE, Scopus, Web of Science, Embase, and Scielo. A total of 133 articles involving the use of peptides in dentistry-related applications were included. The studies involved experimental designs in animals, microorganisms, or cells; clinical trials were also identified within this review. Most of the applications of peptides included caries management, implant osseointegration, guided tissue regeneration, vital pulp therapy, antimicrobial activity, enamel remineralization, periodontal therapy, the surface modification of tooth implants, and the modification of other restorative materials such as dental adhesives and denture base resins. The in vitro and in vivo studies included in this review suggested that peptides may have beneficial effects for treating early carious lesions, promoting cell adhesion, enhancing the adhesion strength of dental implants, and in tissue engineering as healthy promotors of the periodontium and antimicrobial agents. The lack of clinical trials should be highlighted, leaving a wide space available for the investigation of peptides in dentistry. Full article

Background and Objectives: Enamel matrix derivative (EMD) is a biomaterial used for periodontal regenerative therapy due to its properties of stimulating cementum development and bone synthesis. Diabetes is a chronic condition that affects healing and predisposes to infection. The aim of this review was to evaluate the current studies available on the application and results of EMD for periodontal regenerative therapy under diabetic conditions. Materials and Methods: Five databases (PubMed, ResearchGate, Scopus, Web of Science and Google Scholar) were searched for relevant articles, using specific keywords in different combinations. The inclusion criteria were clinical trials, case reports, case studies, and animal studies published in English, where periodontal treatment for bone defects includes EMD, and it is performed under diabetic conditions. Results: Of the 310 articles resulted in search, five studies published between 2012 and 2020 met the inclusion criteria and were selected for the current review. In human studies, the use of EMD in infrabony defects showed favorable results at follow-up. In animal studies, periodontal regeneration was reduced in diabetic rats. Conclusions: EMD might promote bone healing when used under diabetic conditions for the regenerative periodontal therapy. Due to limited number of studies, more data are required to sustain the effects of EMD therapy in diabetic settings. Full article