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Keywords = Porvac®

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15 pages, 2626 KB  
Article
Porvac® Subunit Vaccine Protects Against Three Field Isolates of Classical Swine Fever Virus
by Yusmel Sordo-Puga, María Pilar Rodríguez-Moltó, Danny Pérez-Pérez, Paula Naranjo-Valdés, Talía Sardina-González, Mary Karla Méndez-Orta, Elaine Santana-Rodríguez, Milagros Vargas-Hernández, Carmen Laura Perera, Carlos A. Duarte and Marisela Suárez-Pedroso
Vaccines 2025, 13(2), 196; https://doi.org/10.3390/vaccines13020196 - 17 Feb 2025
Cited by 2 | Viewed by 1846
Abstract
The control of classical swine fever (CSF) in endemic areas has been attempted with modified live vaccines. However, in some regions, the implementation of imperfect vaccination programs has led to a reduction in the genetic diversity of the circulating CSF virus (CSFV) strains [...] Read more.
The control of classical swine fever (CSF) in endemic areas has been attempted with modified live vaccines. However, in some regions, the implementation of imperfect vaccination programs has led to a reduction in the genetic diversity of the circulating CSF virus (CSFV) strains and a change in their virulence. Porvac® subunit vaccine has been shown to provide a rapid onset of protection against the “Margarita” strain. The aim of this study was to evaluate whether the immune response induced by Porvac® is also effective against autochthonous CSFV isolates of low, medium or high virulence. All pigs vaccinated with Porvac® were protected against the disease after challenge. PR-11/10–3 isolate caused a very mild disease in controls, whilst Holguin_2009 isolate produced mild to moderate signs of CSF and one of the pigs died. Finally, controls inoculated with PR-2016 isolate developed moderate to severe signs of CSF and two of them died. Viral replication was detected in controls, but not in pigs immunized with Porvac®. Finally, anti-Erns antibodies were induced in five out of six control pigs but not in any of the vaccinated pigs. These results support the use of Porvac® for the control and elimination of CSF in Cuba and other endemic regions. Full article
(This article belongs to the Special Issue Porcine Virus and Vaccines)
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11 pages, 1624 KB  
Article
Porvac® Subunit Vaccine E2-CD154 Induces Remarkable Rapid Protection against Classical Swine Fever Virus
by Yusmel Sordo-Puga, Marisela Suárez-Pedroso, Paula Naranjo-Valdéz, Danny Pérez-Pérez, Elaine Santana-Rodríguez, Talia Sardinas-Gonzalez, Mary Karla Mendez-Orta, Carlos A. Duarte-Cano, Mario Pablo Estrada-Garcia and María Pilar Rodríguez-Moltó
Vaccines 2021, 9(2), 167; https://doi.org/10.3390/vaccines9020167 - 17 Feb 2021
Cited by 18 | Viewed by 5492
Abstract
Live attenuated C-strain classical swine fever vaccines provide early onset protection. These vaccines confer effective protection against the disease at 5–7 days post-vaccination. It was previously reported that intramuscular administration of the Porvac® vaccine protects against highly virulent classical swine fever virus [...] Read more.
Live attenuated C-strain classical swine fever vaccines provide early onset protection. These vaccines confer effective protection against the disease at 5–7 days post-vaccination. It was previously reported that intramuscular administration of the Porvac® vaccine protects against highly virulent classical swine fever virus (CSFV) “Margarita” strain as early as seven days post-vaccination. In order to identify how rapidly protection against CSFV is conferred after a single dose of the Porvac® subunit vaccine E2-CD154, 15 swine, vaccinated with a single dose of Porvac®, were challenged intranasally at five, three, and one day post-vaccination with 2 × 103 LD50 of the highly pathogenic Cuban “Margarita” strain of the classical swine fever virus. Another five animals were the negative control of the experiment. The results provided clinical and virological data confirming protection at five days post-vaccination. Classical swine fever (CSF)-specific IFNγ T cell responses were detected in vaccinated animals but not detected in unvaccinated control animals. These results provided the first data that a subunit protein vaccine demonstrates clinical and viral protection at five days post-vaccination, as modified live vaccines. Full article
(This article belongs to the Special Issue Development and Application of New Vaccine against Classical Swine Fever Virus)
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