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Keywords = N-acetyldopamine dimers

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13 pages, 4458 KiB  
Article
Anti-Inflammatory and Antioxidative N-Acetyldopamine Dimers from Adult Vespa velutina auraria Smith
by Chao-He Liu, Xiu-Qing Pang, Qun Yu, Wei Zhang, Jing-Lei Xu, Yu-Chen Ma, Lei Huang, Geng Huang, Jia-Peng Wang, Huai Xiao and Zhong-Tao Ding
Molecules 2024, 29(22), 5445; https://doi.org/10.3390/molecules29225445 - 19 Nov 2024
Cited by 1 | Viewed by 1065
Abstract
One undescribed fatty glyceride (1), two unreported N-acetyldopamine dimers (2 and 3), and four known structurally diverse N-acetyldopamine dimers were isolated from adult Vespa velutina auraria Smith. Their structures were elucidated based on a comprehensive analysis of [...] Read more.
One undescribed fatty glyceride (1), two unreported N-acetyldopamine dimers (2 and 3), and four known structurally diverse N-acetyldopamine dimers were isolated from adult Vespa velutina auraria Smith. Their structures were elucidated based on a comprehensive analysis of spectroscopic data, HRESIMS, and NMR calculations with ML_J_DP4, and the absolute configurations of 2 and 3 were determined via ECD calculations. Regarding their bioactivities, compounds 5 and 6 can inhibit the production of NO. Moreover, compounds 3, 5 and 7 showed stronger antioxidant activity than the positive control (VC) at 14 μg/mL. A network pharmacology study was used to explore the potential bioactive mechanisms. In addition, a docking study of anti-inflammatory and antioxidative compounds was also performed. Full article
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17 pages, 3221 KiB  
Article
Periostracum Cicadae Extract and N-Acetyldopamine Regulate the Sleep-Related Neurotransmitters in PCPA-Induced Insomnia Rats
by Dongge Wang, Tingjuan Wu, Jinghui Jin, Yanpo Si, Yushi Wang, Xiaojia Ding, Tao Guo and Wenjun Wei
Molecules 2024, 29(15), 3638; https://doi.org/10.3390/molecules29153638 - 31 Jul 2024
Cited by 6 | Viewed by 2205
Abstract
Insomnia is the second most prevalent mental illness worldwide. Periostracum cicadae (PC), as an animal traditional Chinese medicine with rich pharmacological effects, has been documented as a treatment for children’s night cries, and later extended to treat insomnia. This study aimed to investigate [...] Read more.
Insomnia is the second most prevalent mental illness worldwide. Periostracum cicadae (PC), as an animal traditional Chinese medicine with rich pharmacological effects, has been documented as a treatment for children’s night cries, and later extended to treat insomnia. This study aimed to investigate the effects of PC extract and N-acetyldopamine compounds in ameliorating insomnia. The UPLC-ESI-QTOF-MS analysis determined that PC extract mainly contained N-acetyldopamine components. Previously, we also isolated some acetyldopamine polymers from PC extract, among which acetyldopamine dimer A (NADA) was present in high content. Molecular docking and molecular dynamic simulations demonstrated that NADA could form stable complexes with 5-HT1A, BDNF, and D2R proteins, respectively. The effects of PC extract and NADA on insomnia were evaluated in the PCPA-induced insomnia model. The results indicated that PC extract and NADA could effectively ameliorate hypothalamic pathology of insomnia rats, increase the levels of 5-HT, GABA, and BDNF, and decrease the levels of DA, DOPAC, and HVA. Meanwhile, the PC extract and NADA also could significantly affect the expression of 5-HT1A, BDNF, and DARPP-32 proteins. This study proved that PC extract and acetyldopamine dimer A could effectively improve PCPA-induced insomnia in rats. It is speculated that the main pharmacological substances of PC were acetyldopamine components. Full article
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8 pages, 755 KiB  
Article
Identification of N-Acetyldopamine Dimers from the Dung Beetle Catharsius molossus and Their COX-1 and COX-2 Inhibitory Activities
by Juan Lu, Qin Sun, Zheng-Chao Tu, Qing Lv, Pi-Xian Shui and Yong-Xian Cheng
Molecules 2015, 20(9), 15589-15596; https://doi.org/10.3390/molecules200915589 - 27 Aug 2015
Cited by 27 | Viewed by 5006
Abstract
Recent studies focusing on identifying the biological agents of Catharsius molossus have led to the identification of three new N-acetyldopamine dimers molossusamide A–C (1-3) and two known compounds 4 and 5. The structures of the new compounds were [...] Read more.
Recent studies focusing on identifying the biological agents of Catharsius molossus have led to the identification of three new N-acetyldopamine dimers molossusamide A–C (1-3) and two known compounds 4 and 5. The structures of the new compounds were identified by comprehensive spectroscopic evidences. Compound 4 was found to have inhibitory effects towards COX-1 and COX-2. Full article
(This article belongs to the Section Natural Products Chemistry)
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