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Keywords = Mirabolides A and B

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11 pages, 768 KB  
Article
Mirabolides A and B; New Cytotoxic Glycerides from the Red Sea Sponge Theonella mirabilis
by Dina R. Abou-Hussein and Diaa T. A. Youssef
Mar. Drugs 2016, 14(8), 155; https://doi.org/10.3390/md14080155 - 18 Aug 2016
Cited by 6 | Viewed by 7076
Abstract
As a part of our continuing work to find out bioactive lead molecules from marine invertebrates, the CHCl3 fraction of the organic extract of the Red Sea sponge Theonella mirabilis showed cytotoxic activity in our primary screen. Bioassay-guided purification of the active [...] Read more.
As a part of our continuing work to find out bioactive lead molecules from marine invertebrates, the CHCl3 fraction of the organic extract of the Red Sea sponge Theonella mirabilis showed cytotoxic activity in our primary screen. Bioassay-guided purification of the active fractions of the sponge’s extract resulted in the isolation of two new glycerides, mirabolides A and B (1 and 2), together with the reported 4-methylene sterols, conicasterol (3) and swinhosterol B (4). The structures of the compounds were assigned by interpretation of their 1D (1H, 13C), 2D (COSY, HSQC, HMBC, ROESY) NMR spectral data and high-resolution mass determinations. Compounds 14 displayed marked cytotoxic activity against human breast adenocarcinoma cell line (MCF-7) with IC50 values of 16.4, 5.18, 6.23 and 3.0 μg/mL, respectively, compared to 5.4 μg/mL observed by doxorubicin as reference drug. Full article
(This article belongs to the Collection Bioactive Compounds from Marine Invertebrates)
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