Search Results (4)

Biocomplexity, chaos, and fractality can explain the heterogeneity of aging individuals by regarding longevity as a “secondary product” of the evolution of a dynamic nonlinear system. Genetic-environmental interactions drive the individual senescent phenotype toward normal, pathological, or successful aging. Mitochondrial dysfunctions and mitochondrial DNA (mtDNA) mutations represent a possible mechanism shared by disease(s) and the aging process. This study aims to characterize the senescent phenotype and discriminate between normal (nA) and pathological (pA) aging by mtDNA mutation profiling. MtDNA sequences from hospitalized and non-hospitalized subjects (age-range: 65–89 years) were analyzed and compared to the revised Cambridge Reference Sequence (rCRS). Fractal properties of mtDNA sequences were displayed by chaos game representation (CGR) method, previously modified to deal with heteroplasmy. Fractal lacunarity analysis was applied to characterize the senescent phenotype on the basis of mtDNA sequence mutations. Lacunarity parameter β, from our hyperbola model function, was statistically different (p < 0.01) between the nA and pA groups. Parameter β cut-off value at 1.26 × 10⁻³ identifies 78% nA and 80% pA subjects. This also agrees with the presence of MT-CO gene variants, peculiar to nA (C9546m, 83%) and pA (T9900w, 80%) mtDNA, respectively. Fractal lacunarity can discriminate the senescent phenotype evolving as normal or pathological aging by individual mtDNA mutation profile. Full article

Aerial photography involves capturing images from aircraft and other flying objects, including Unmanned Aerial Vehicles (UAV). Aerial images are used in many fields and can contain sensitive information that requires secure processing. We proposed an innovative new cryptosystem for the processing of aerial images utilizing a chaos-based private key block cipher method so that the images are secure even on untrusted cloud servers. The proposed cryptosystem is based on a hybrid technique combining the Mersenne Twister (MT), Deoxyribonucleic Acid (DNA), and Chaotic Dynamical Rossler System (MT-DNA-Chaos) methods. The combination of MT with the four nucleotides and chaos sequencing creates an enhanced level of security for the proposed algorithm. The system is tested at three separate phases. The combined effects of the three levels improve the overall efficiency of the randomness of data. The proposed method is computationally agile, and offered more security than existing cryptosystems. To assess, this new system is examined against different statistical tests such as adjacent pixels correlation analysis, histogram consistency analyses and its variance, visual strength analysis, information randomness and uncertainty analysis, pixel inconsistency analysis, pixels similitude analyses, average difference, and maximum difference. These tests confirmed its validity for real-time communication purposes. Full article

Increasing evidence implicates mitochondrial dysfunction in the etiology of Parkinson’s disease (PD). Mitochondrial DNA (mtDNA) mutations are considered a possible cause and this mechanism might be shared with the aging process and with other age-related neurodegenerative disorders such as Alzheimer’s disease (AD). We have recently proposed a computerized method for mutated mtDNA characterization able to discriminate between AD and aging. The present study deals with mtDNA mutation-based profiling of PD. Peripheral blood mtDNA sequences from late-onset PD patients and age-matched controls were analyzed and compared to the revised Cambridge Reference Sequence (rCRS). The chaos game representation (CGR) method, modified to visualize heteroplasmic mutations, was used to display fractal properties of mtDNA sequences and fractal lacunarity analysis was applied to quantitatively characterize PD based on mtDNA mutations. Parameter β, from the hyperbola model function of our lacunarity method, was statistically different between PD and control groups when comparing mtDNA sequence frames corresponding to GenBank np 5713-9713. Our original method, based on CGR and lacunarity analysis, represents a useful tool to analyze mtDNA mutations. Lacunarity parameter β is able to characterize individual mutation profile of mitochondrial genome and could represent a promising index to discriminate between PD and aging. Full article

Multimedia encryption innovation is one of the primary ways of securely and privately guaranteeing the security of media transmission. There are many advantages when utilizing the attributes of chaos, for example, arbitrariness, consistency, ergodicity, and initial condition affectability, for any covert multimedia transmission. Additionally, many more benefits can be introduced with the exceptional space compliance, unique information, and processing capability of real mitochondrial deoxyribonucleic acid (mtDNA). In this article, color image encryption employs a confusion process based on a hybrid chaotic map, first to split each channel of color images into n-clusters; then to create global shuffling over the whole image; and finally, to apply intrapixel shuffling in each cluster, which results in very disordered pixels in the encrypted image. Then, it utilizes the rationale of human mitochondrial genome mtDNA to diffuse the previously confused pixel values. Hypothetical examination and trial results demonstrate that the anticipated scheme exhibits outstanding encryption, as well as successfully opposes chosen/known plain text, statistical, and differential attacks. Full article