Search Results (5)

Background/Objectives: Feelings of loneliness are common in people living with dementia (PLWD) in long-term care (LTC). The goals of this study were to describe the development of a novel virtual companion for PLWD living in LTC and assess its feasibility and acceptability. Methods: The computer-generated virtual companion, presented using a head-mounted virtual reality display, was developed in two stages. In Stage 1, the virtual companion asked questions designed to encourage conversation and reminiscence. In Stage 2, more powerful artificial intelligence tools allowed the virtual companion to engage users in nuanced discussions on any topic. PLWD in LTC tested the application at each stage to assess feasibility and acceptability. Results: Ten PLWD living in LTC participated in Stage 1 (4 men and 6 women; average 82 years old) and Stage 2 (2 men and 8 women; average 87 years old). Session lengths ranged from 0:00 to 5:30 min in Stage 1 and 0:00 to 53:50 min in Stage 2. Speech recognition issues and a limited repertoire of questions limited acceptance in Stage 1. Enhanced conversational ability in Stage 2 led to intimate and meaningful conversations with many participants. Many users found the head-mounted display heavy. There were no complaints of simulator sickness. The virtual companion was best suited to PLWD who could engage in reciprocal conversation. After Stage 2, response latency was identified as an opportunity for improvement in future versions. Conclusions: Virtual reality and artificial intelligence can be used to create a virtual companion that is acceptable and enjoyable to some PLWD living in LTC. Ongoing innovations in hardware and software will allow future iterations to provide more natural conversational interaction and an enhanced social experience. Full article

The article focuses on two parafictional figures created by Israeli artists at about the same time in the early 2000s: Oreet Ashery’s Marcus Fisher and Roee Rosen’s Justine Frank. Through a close reading of these case studies, I examine the phenomenon of parafictional characters as extreme cases of voice appropriation. Against the background of rising international concern with cultural appropriation, and of the Israeli sociopolitical context characterized by a multiplicity of often conflicting identities, I argue that such appropriation is, in fact, a basic aesthetic procedure. Using Hannah Arendt’s reading of Immanuel Kant’s aesthetic judgment as political judgment, and her articulation of an “enlarged mentality” as necessary for both aesthetic and political thinking, the article demonstrates how the ability to imagine a position different from your own is inherent for aesthetic representation as well as reception. Full article

Background: Head and neck cancer (HNC) patients experience distressing symptoms that can significantly impact their health-related quality of life (HRQoL). We analyzed the implementation of a nurse-led consultation (NLC) and explored potential associations with symptom burden in HNC patients. Methods: We retrospectively analyzed routinely collected data to describe the implementation of the nurse-led interventions and the evolution of the M.D. Anderson Symptom Inventory scores as patient-reported outcome measures (PROMs). Patients who received routine care (n = 72) were compared with patients in the NLC group (n = 62) at a radiation oncology unit between 2017 and 2019. PROMs were measured at T0 (between simulation and the first week of radiotherapy), T1 (week 3–4), and T2 (week 5–6). Results: Screening for nutrition, smoking, oral cavity status, and capacity for swallowing/chewing, but not for pain, was applied in >80% of patients in the NLC group from T0 to T1. Education (16%) and care coordination (7%) were implemented to a lesser extent. Symptom burden increased over time with no significant differences between groups. Conclusions: The nurse-led consultation was not associated with symptom burden over time. A larger implementation study including a detailed process evaluation, larger sample size, and a focus on long-term effects is needed. Full article

PD-L1 (programmed death-ligand 1, B7-H1, CD274), the ligand for PD-1 inhibitory receptor, is expressed on various tumors, and its expression is correlated with a poor prognosis in melanoma. Anti-PD-L1 mAbs have been developed along with anti-CTLA-4 and anti-PD-1 antibodies for immune checkpoint inhibitor (ICI) therapy, and anti-PD-1 mAbs are now used as first line treatment in melanoma. However, many patients do not respond to ICI therapies, and therefore new treatment alternatives should be developed. Because of its expression on the tumor cells and on immunosuppressive cells within the tumor microenvironment, PD-L1 represents an interesting target for targeted alpha-particle therapy (TAT). We developed a TAT approach in a human melanoma xenograft model that stably expresses PD-L1 using a ²¹³Bi-anti-human-PD-L1 mAb. Unlike treatment with unlabeled anti-human-PD-L1 mAb, TAT targeting PD-L1 significantly delayed melanoma tumor growth and improved animal survival. A slight decrease in platelets was observed, but no toxicity on red blood cells, bone marrow, liver or kidney was induced. Anti-tumor efficacy was associated with specific tumor targeting since no therapeutic effect was observed in animals bearing PD-L1 negative melanoma tumors. This study demonstrates that anti-PD-L1 antibodies may be used efficiently for TAT treatment in melanoma. Full article

This article explores the exhibitions of Picasso’s works in the first two decades of his artistic career, as well as the dealers and collectors who came into contact with them. It describes the relationship between Picasso and his first dealers, Pere Manyach, Berthe Weill, Clovis Sagot, Père Soulier, Ambroise Vollard, Daniel-Henry Kahnweiler, Georg Caspari, L. W. Guthier, Hans Goltz, Heinrich Thannhauser, Otto Feldmann, Alfred Flechtheim, Emil Richter, Gottfried Tanner, Michael Brenner, R. J. Coady, Léonce Rosenberg, Paul Rosenberg, etc.; as well as his first collectors, Leo and Gertrude Stein, Olivier Sainsère, Joachim Gasquet, Wilhelm Uhde, Herman Rupf, Vincenc Kramář, Frank Stoop, Hugo Perls, Edwin Suermondt, Dr. Paul Ferdinand Schmidt, Princess Mechtilde Lichnowsky, Henry Simms, Ludwig and Rosy Fischer, Professor Wilhelm Kreis, Adolf Erblösch, Justin K. Thannhauser, Sergei Ivanovich Shchukin, Ivan A. Morosov, etc. It also identifies all important Picasso expositions in this time period and how those dealers and collectors were involved in their arrangement. The information provided here has been excerpted from an exhaustive study of the critical literature on Pablo Picasso, as well as from published exhibition catalogues. Full article