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Article

7 Citations

1,826 Views

26 Pages

Triterpenes of Prunella vulgaris Inhibit Triple-Negative Breast Cancer by Regulating PTP1B/PI3K/AKT/mTOR and IL-24/CXCL12/CXCR4 Pathways

Yamei Li,
Hongshan Luo,
Xiulian Lin,
Linye Hua,
Jiayao Wang,
Jingchen Xie,
Zhimin Zhang,
Zhe Shi,
Minjie Li and
Qiuxian Peng
+ 3 authors

Int. J. Mol. Sci.2025, 26(5), 1959;https://doi.org/10.3390/ijms26051959

24 February 2025

Triple-negative breast cancer (TNBC) is a type of breast cancer characterized by high molecular heterogeneity. Owing to the lack of effective therapeutic strategies, patients with TNBC have a poor prognosis. Prunella vulgaris L. has the effects of re...

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Review

18 Citations

5,300 Views

22 Pages

Crosstalk between CXCL12/CXCR4/ACKR3 and the STAT3 Pathway

Zelong Ma,
Faxiao Zhou,
Hua Jin and
Xiaoming Wu

Cells2024, 13(12), 1027;https://doi.org/10.3390/cells13121027

13 June 2024

The reciprocal modulation between the CXCL12/CXCR4/ACKR3 axis and the STAT3 signaling pathway plays a crucial role in the progression of various diseases and neoplasms. Activation of the CXCL12/CXCR4/ACKR3 axis triggers the STAT3 pathway through mult...

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Article

1 Citations

1,771 Views

22 Pages

The Intrinsic Neuronal Activation of the CXCR4 Signaling Axis Is Associated with a Pro-Regenerative State in Cervical Primary Sensory Neurons Conditioned by a Sciatic Nerve Lesion

Petr Dubový,
Ivana Hradilová-Svíženská,
Václav Brázda,
Anna Jambrichová,
Viktorie Svobodová and
Marek Joukal

Int. J. Mol. Sci.2025, 26(1), 193;https://doi.org/10.3390/ijms26010193

29 December 2024

CXCL12 and CXCR4 proteins and mRNAs were monitored in the dorsal root ganglia (DRGs) of lumbar (L4–L5) and cervical (C7–C8) spinal segments of naïve rats, rats subjected to sham operation, and those undergoing unilateral complete sci...

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Article

47 Citations

7,998 Views

16 Pages

CXCL12/CXCR4 Axis Regulates Aggrecanase Activation and Cartilage Degradation in a Post-Traumatic Osteoarthritis Rat Model

Weiwei Lu,
Jia Shi,
Jinming Zhang,
Zhengtao Lv,
Fengjing Guo,
Hui Huang,
Wentao Zhu and
Anmin Chen

Int. J. Mol. Sci.2016, 17(10), 1522;https://doi.org/10.3390/ijms17101522

29 September 2016

We evaluated the role of the CXCL12/CXCR4 (C-X-C motif chemokine ligand 12/C-X-C chemokine receptor type 4) axis in aggrecanase-mediated cartilage degradation, and explored the underlying mechanism in a post-traumatic osteoarthritis rat model. Expres...

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Review

339 Citations

25,241 Views

15 Pages

The IL-8/IL-8R Axis: A Double Agent in Tumor Immune Resistance

Justin M. David,
Charli Dominguez,
Duane H. Hamilton and
Claudia Palena

Vaccines2016, 4(3), 22;https://doi.org/10.3390/vaccines4030022

24 June 2016

Interleukin-8 (IL-8, CXCL8) is a pro-inflammatory chemokine produced by various cell types to recruit leukocytes to sites of infection or tissue injury. Acquisition of IL-8 and/or its receptors CXCR1 and CXCR2 are known to be a relatively common occu...

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