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Keywords = Hedychium ellipticum

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7 pages, 363 KB  
Communication
Cytotoxic Labdane Diterpenes from Hedychium ellipticum Buch.-Ham. ex Sm.
by Sineenard Songsri and Nuchnipa Nuntawong
Molecules 2016, 21(6), 749; https://doi.org/10.3390/molecules21060749 - 9 Jun 2016
Cited by 24 | Viewed by 6310
Abstract
In order to reveal the constituents and their biological activities, we carried out a phytochemical study on Hedychium ellipticum Buch.-Ham. ex Sm. (Zingiberaceae). Ten labdane diterpenoids (110) were isolated from the rhizomes of H. ellipticum for the first time. [...] Read more.
In order to reveal the constituents and their biological activities, we carried out a phytochemical study on Hedychium ellipticum Buch.-Ham. ex Sm. (Zingiberaceae). Ten labdane diterpenoids (110) were isolated from the rhizomes of H. ellipticum for the first time. Their structures were identified on the basis of spectroscopic analyses including two-dimensional NMR and comparison with literature data. All of these compounds were evaluated for their antimycobacterial activity against Mycobacterium tuberculosis and cytotoxicity against KB, MCF7, NCI-H187 and Vero cells. The result showed that compounds 1 and 7 exhibited moderate activity against Mycobacterium tuberculosis and compounds 4, 6 and 7 displayed remarkable cytotoxic activity. This is the first report on the presence of all compounds in H. ellipticum and the first time that their structure activity relationship has been discussed. Full article
(This article belongs to the Special Issue Diterpene and Its Significance in Natural Medicine)
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