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Keywords = Ethyl 2-methylacetoacetate

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10 pages, 2330 KB  
Article
Synthesis, Structural Determination, and Antifungal Activity of Novel Fluorinated Quinoline Analogs
by Xinpeng Sun, Wei Yu, Lijing Min, Liang Han, Xuewen Hua, Jianjun Shi, Nabo Sun and Xinghai Liu
Molecules 2023, 28(8), 3373; https://doi.org/10.3390/molecules28083373 - 11 Apr 2023
Cited by 10 | Viewed by 3719
Abstract
A series of new fluorinated quinoline analogs were synthesized using Tebufloquin as the lead compound, 2-fluoroaniline, ethyl 2-methylacetoacetate, and substituted benzoic acid as raw materials. Their structures were confirmed by 1H NMR, 13C NMR, and HRMS. The compound 8-fluoro-2,3-dimethylquinolin-4-yl 4-(tert [...] Read more.
A series of new fluorinated quinoline analogs were synthesized using Tebufloquin as the lead compound, 2-fluoroaniline, ethyl 2-methylacetoacetate, and substituted benzoic acid as raw materials. Their structures were confirmed by 1H NMR, 13C NMR, and HRMS. The compound 8-fluoro-2,3-dimethylquinolin-4-yl 4-(tert-butyl)benzoate (2b) was further determined by X-ray single-crystal diffraction. The antifungal activity was tested at 50 μg/mL, and the bioassay results showed that these quinoline derivatives had good antifungal activity. Among them, compounds 2b, 2e, 2f, 2k, and 2n exhibited good activity (>80%) against S. sclerotiorum, and compound 2g displayed good activity (80.8%) against R. solani. Full article
(This article belongs to the Special Issue Advances in Novel Pesticide Discovery)
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9 pages, 2750 KB  
Article
Co-Immobilization of Ketoreductase and Glucose Dehydrogenase
by Tatiana Petrovičová, Kristína Markošová, Zuzana Hegyi, Ioulia Smonou, Michal Rosenberg and Martin Rebroš
Catalysts 2018, 8(4), 168; https://doi.org/10.3390/catal8040168 - 20 Apr 2018
Cited by 27 | Viewed by 7867
Abstract
A two-enzyme system composed of immobilized ketoreductase (Hansenula polymorpha) and glucose dehydrogenase (Bacillus megaterium) was developed for the asymmetric reduction of keto esters to optically active hydroxy esters via immobilization in polyvinyl alcohol (PVA) gel particles. The concentration of [...] Read more.
A two-enzyme system composed of immobilized ketoreductase (Hansenula polymorpha) and glucose dehydrogenase (Bacillus megaterium) was developed for the asymmetric reduction of keto esters to optically active hydroxy esters via immobilization in polyvinyl alcohol (PVA) gel particles. The concentration of enzymes was optimized, and the final particles were used 18 times in a row in a batch mode to achieve minimal loss of activity and complete conversion of the model substrate, β-ketoester ethyl-2-methylacetoacetate. Excellent stability was also achieved using new storage conditions of PVA particles, with 80% of activity being retained after almost 10 months. Full article
(This article belongs to the Special Issue Immobilized Biocatalysts)
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2 pages, 125 KB  
Short Note
5-Hydroxy-2-methyl-3-oxo-6-(2,2,3-trimethyl-cyclopent-3-enyl)-hexanoic acid ethyl ester
by Mercedes Pérez-Bonilla, Juan M. Castro, Pablo J. Linares-Palomino, Sofía Salido, Joaquín Altarejos, Manuel Nogueras and Adolfo Sánchez
Molbank 2005, 2005(1), M396; https://doi.org/10.3390/M396 - 1 Jul 2005
Viewed by 3700
Abstract
Sodium (241 mg, 10.48 mmol) was added to absolute ethanol (40 mL) and the mixture refluxed until sodium reacted completely. Full article
1 pages, 125 KB  
Short Note
(Z)-2-Methyl-3-(1-phenyl-ethylamino)-but-2-enoic acid ethyl ester
by Mercedes Pérez-Bonilla, Juan M. Castro, Pablo J. Linares-Palomino, Joaquín Altarejos, Manuel Nogueras, Adolfo Sánchez and Sofía Salido
Molbank 2005, 2005(1), M395; https://doi.org/10.3390/M395 - 1 Jul 2005
Cited by 1 | Viewed by 3863
Abstract
p-Toluenesulfonic acid (48 mg, 0.25 mmol) was added to a stirred mixture of ethyl 2-methyl-acetoacetate (1) (346 mg, 2.40 mmol) and a-methylbenzylamine (2) (358 mg, 2.95 mmol) in toluene (13 mL) [1].[...] Full article
2 pages, 48 KB  
Short Note
(E)-6-(2,2,3-Trimethyl-cyclopent-3-enyl)-hex-4-en-3-one
by Concepción Badía, Juan M. Castro, Pablo J. Linares-Palomino, Sofía Salido, Joaquín Altarejos, Manuel Nogueras and Adolfo Sánchez
Molbank 2004, 2004(1), M388; https://doi.org/10.3390/M388 - 29 Mar 2004
Cited by 2 | Viewed by 5039
Abstract
Ethyl 2-methylacetoacetate (2) (727 mg, 4.53 mmol) was added to a stirred solution of NaH (184 mg, 4.60 mmol) in dioxane (25 mL).[...] Full article
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