Search Results (6)

Invasive fungal disease (IFD) is a recognised and potentially life-threatening complication of chronic graft-versus-host disease (cGVHD) and its treatment. Invasive aspergillosis (IA), most often due to the species Aspergillus fumigatus, is the leading IFD in this setting. IA can occur during the early weeks following allogeneic haematopoietic stem cell transplantation (HSCT) coinciding with profound neutropenia, but increasingly, cases of IA occur after engraftment, coinciding with the occurrence of cGVHD. Immunomodulatory treatments of cGVHD can impair innate immune responses to inhaled Aspergillus conidia, increasing the risk of developing IA. Here, in a pilot study, we present an analysis of the phenotypic characteristics (phagocytic efficiency, fungal killing, and cytokine release) of circulating monocytes derived from patients with cGVHD compared to healthy volunteers. We found that there was no statistically significant difference in their ability to phagocytose A. fumigatus conidia, and while there was a trend in their reduced ability to kill conidia, this was not significant when compared to the ability of volunteers’ monocytes to do so. Although we could not demonstrate in this small cohort of patients with cGVHD that monocytes may be a factor in the increased susceptibility to IA, further investigation of larger numbers of study subjects is warranted so that in vitro biomarkers may be developed for immune responses to Aspergillus in patients with cGVHD. Full article

Anscombe once said to Anthony Kenny that “On the topic of religion, Wittgenstein is sheer poison”. This paper offers an assessment of that view. I take it that Anscombe meant that Wittgenstein was a bad influence rather than that his views were necessarily false, although she seems to have been uncertain about what exactly his views were. In “Paganism, Superstition and Philosophy”, she identifies five ideas that make up “a certain current in philosophy which has a strong historical connection with Wittgenstein”. I identify some of the sources of these ideas, in Wittgenstein’s writing and in work by some of his followers, and consider what Anscombe’s objections to them might have been. I also look at whether we should think of these ideas as belonging either to Wittgenstein’s philosophy of religion or to his personal beliefs. This will involve some consideration of how far we can, or should try to, separate the personal from the philosophical. So far as he held objectionable views about religion, I argue that these ought to be considered personal rather than philosophical. Full article

Background: European countries have included healthcare workers (HCWs) among priority groups for COVID-19 vaccination. We established a multi-country hospital network to measure the SARS-CoV-2 incidence and effectiveness of COVID-19 vaccines among HCWs against laboratory-confirmed SARS-CoV-2 infection. Methods: HCWs from 19 hospitals in 10 countries participated in a dynamic prospective cohort study, providing samples for SARS-CoV-2 testing at enrolment and during weekly/fortnightly follow-up. We measured the incidence during pre-Delta (2 May–6 September 2021), Delta (7 September–14 December 2021), and Omicron (15 December 2021–2 May 2023) waves. Using Cox regression, we measured the relative vaccine effectiveness (rVE) of the first COVID-19 booster dose versus primary course alone during Delta and Omicron waves. Results: We included a total of 3015 HCWs. Participants were mostly female (2306; 79%), with a clinical role (2047; 68%), and had a median age of 44 years. The overall incidence of SARS-CoV-2 infection was 3.01/10,000 person-days during pre-Delta, 4.21/10,000 during Delta, and 23.20/10,000 during Omicron waves. rVE was 59% (95% CI: −25; 86) during Delta and 22% (1; 39) during Omicron waves. rVE was 51% (30; 65) 7–90 days after the first booster dose during the Omicron wave. Conclusions: The incidence of SARS-CoV-2 infection among HCWs was higher during the Omicron circulation period. The first COVID-19 vaccine booster provided additional protection against SARS-CoV-2 infection compared to primary course vaccination when recently vaccinated <90 days. This multi-country HCW cohort study addressing infection as the main outcome is crucial for informing public health interventions for HCWs. Full article

This essay begins with preliminary observations about the nature of agnosticism. Based on the term’s etymology, in this essay an agnostic about some proposition (e.g., God exists) is someone who does not know whether the proposition is true. Being an agnostic about the truth of a proposition is compatible with the proposition appearing to be true or the state of affairs obtains but incompatible with an agnostic knowing its truth or that the state of affairs obtains. (Reference to propositions and states of affairs is intended to be inclusive, rather than a controversial metaphysical distinction.) Based on apparent virtues and vices, reasons are offered about when agnosticism (or the profession of agnosticism) is virtuous or philosophically desirable and when either actual agnosticism or its profession seems to be a vice or undesirable. The essay concludes with challenging Anthony Kenny’s case for agnosticism about theism based on the virtue of humility. The central claims about apparent virtues and vices rest on the positive epistemic standing of appearances as defended by many so-called “common sense philosophers” Thomas Reid, Roderick Chisholm, and, more recently, Thomas Nagel’s thesis about the justified status of the appearance of values. Full article

The Indian diet is becoming westernized with a potential threat to human health. This ecological study aimed at analyzing the nutritional transition in India during the 1990–2019 period within the framework of the newly developed 3V index, considering the degree of processing starting with industrially processed foods (IPFs, i.e., the Real/’Vrai’ metric 1), plant/animal calorie ratio (i.e., the Vegetal metric 2), and diversity of food intake (i.e., the Varied metric 3). Total and food group (n = 14) caloric intakes, percentages of animal and IPF calories, adequacy to the Indian Recommended Dietary Allowances, and prevalence of chronic diseases were retrieved from web databases (e.g., OECD.Stats, Our World in Data and FAO-STAT) and Indian food composition table. The total calorie intake increased by 31% over thirty years, being mainly linked to increased consumption of dairy products and IPF, but still remains below the average recommended intake in 2019. The IPF and animal calorie shares increased from 3.6 to 11.6% and 15.1 to 24.3%, respectively, while micronutrient intakes improved in 2019. In the same time, prevalence of overweight/obesity and type 2 diabetes, and cardiovascular disease mortality increased. In conclusion, the evolution of the Indian diet deviates from metrics 1 and 2 and improves in metric 3, which may not be a sufficient metric in terms of the alleviation of chronic diseases. Therefore, while improving food diversity and replacing refined with wholegrain cereals, Indians should also curb increasing their consumption of IPF and animal calories. Full article

In current times of increasing global decontamination concerns, sustainable and environmentally-friendly technologies that possess rapid and effective disinfection capabilities are necessary for public health and safety. In this study, we evaluate the potential of ozone-based technology to reveal its immense potential in disinfection applications. Ozonated water generated by an electrolytic method was utilised to quantify ozone retention as a function of mineralogical composition for microbial decontamination. The impacts of temperature and detergent concentration on ozone concentration are critically analysed, as well as ozone’s decomposition and stain removal characteristics. In addition, fabric swatches inoculated with known concentrations of environmental microbes (Escherichia coli, Staphylococcus aureus, Candida albicans, and Aspergillus fumigatus) are washed with ozonated water to ascertain the impact of wash duration on bacterial removal efficiency. The results show significant improvement in the stability and retention potential of ozone in mineral water at low temperature and in the presence of a detergent. The experiments demonstrate first-order decomposition kinetics of ozone in aqueous formulations. The disinfection potency of ozone is also substantiated by a significant removal of microbiota on the fabric utilised (up to 7 log reduction for the bacteria analysed), thus making it effective for sterilisation applications. This also reduces the need for toxic chemicals or chemicals with toxic by-products (e.g., chlorine) for large-scale decontamination operations in various industries. Full article