Search Results (1,770)

Objectives: To synthesize evidence on artificial intelligence (AI)-enabled medical history taking (anamnesis)—beyond large language models (LLMs) alone—and to translate findings into implications and research priorities for head and neck surgery. Methods: We performed a PRISMA-informed narrative review. Searches from database inception to 31 December 2025 (updated 3 January 2026) were conducted in MEDLINE (PubMed), Embase, Scopus, Web of Science Core Collection, IEEE Xplore, and ACM Digital Library, supplemented by medRxiv/arXiv screening and citation chasing. We included studies evaluating or describing AI-supported history capture/summarization, conversational interviewing, symptom checker/digital triage, EHR-integrated intake-to-decision support pipelines, voice interviewing, education/training systems, and governance/ethical considerations related to digital anamnesis. Findings were synthesized by system category and by cross-cutting outcome domains, with a head and neck surgery interpretive lens. Results: Fifty studies (2014–2025) were included. Evidence most consistently suggested feasibility and acceptability of pre-consultation computer-assisted history taking and the potential to reduce documentation burden and improve structured capture. In contrast, symptom checkers and digital triage tools showed highly variable diagnostic/triage performance and prominent safety concerns, highlighting the importance of conservative red-flag escalation strategies, continuous monitoring, and clear accountability. LLM-based diagnostic dialogue demonstrated strong performance in controlled evaluations, but prospective real-world validation, governance, and workflow integration remain limited. Conclusions: AI-enabled anamnesis comprises heterogeneous tools with uneven evidence. For head and neck surgery, potential near-term applications may include structured pre-visit intake, clinician-facing summarization, and training applications, whereas autonomous triage warrants harm-oriented, specialty-calibrated validation and robust governance prior to broader clinical reliance. Full article

This paper provides a comprehensive survey of Human–Robot Interaction (HRI) for indoor mobile robots operating in human-centered environments such as hospitals, laboratories, offices, and homes. We review interaction modalities—including speech, gesture, touch, visual, and multimodal interfaces—and examine key user experience factors such as usability, trust, and social acceptance. Implementation challenges are discussed, encompassing safety, privacy, and regulatory considerations. Representative case studies, including healthcare and domestic platforms, highlight design trade-offs and integration lessons. We identify critical technical challenges, including robust perception, reliable multimodal fusion, navigation in dynamic spaces, and constraints on computation and power. Finally, we outline future directions, including embodied AI, adaptive context-aware interactions, and standards for safety and data protection. This survey aims to guide the development of indoor mobile robots capable of collaborating with humans naturally, safely, and effectively. Full article

Artificial intelligence (AI) has shown substantial potential to improve patient outcomes in parenteral nutrition by enabling individualised nutritional strategies, early prediction of metabolic and infectious complications, and optimised real-time clinical decision-making. Evidence from global clinical practice demonstrates that AI integration can enhance patient safety, reduce complication rates, and improve resource utilisation. In Bulgaria, recent developments in parenteral nutrition reflect progress toward standardisation, wider availability of modern formulations, and alignment with international clinical guidelines. However, the adoption of AI-driven systems for personalised nutrition planning and continuous risk assessment remains limited. Key barriers include the availability and quality of clinical data, regulatory and ethical considerations, and the need for targeted training of healthcare professionals. This review highlights both the opportunities and challenges associated with implementing AI in parenteral nutrition in the Bulgarian context. Potential benefits include improved patient outcomes, shorter hospital stays, more efficient healthcare delivery, and alignment with international best practices. At the same time, overcoming infrastructural, regulatory, and educational barriers is essential for successful implementation. Conclusions: The integration of AI into parenteral nutrition requires a multidisciplinary approach that combines clinical expertise, technological innovation, and supportive health policy. Such an approach offers the potential to sustainably enhance patient care in Bulgaria and position national practice in line with leading global standards. Full article

Background: Artificial intelligence is emerging as a promising tool in surgical oncology, with growing evidence suggesting potential applications in diagnostic support, intraoperative guidance, and perioperative risk assessment. In gastric cancer surgery, emerging applications range from AI-assisted endoscopic detection to data-driven perioperative risk prediction, while some technological developments, particularly in robotic autonomy, derive from broader surgical or experimental models that may inform future gastric procedures. Methods: A narrative review was conducted following established methodological standards, including the Scale for the Assessment of Narrative Review Articles (SANRA) and the Search–Appraisal–Synthesis–Analysis (SALSA) framework. English-language studies indexed in PubMed, Scopus, Embase, and Web of Science up to October 2025 were included. Evidence was synthesized thematically across five domains: AI-assisted anatomical recognition and lymphadenectomy support, autonomous robotic systems, early cancer detection, perioperative predictive and frailty models, and ethical and regulatory considerations. Results: AI-based computer vision and deep learning algorithms have demonstrated promising capabilities for real-time anatomical recognition, surgical phase classification, and intraoperative guidance, although evidence of direct patient-level benefit remains limited. In diagnostic settings, AI-assisted endoscopy and Raman spectroscopy have been shown to improve early lesion detection and reduce dependence on operator experience. Predictive models, including MySurgeryRisk and AI-driven frailty assessments, may support individualized prehabilitation planning and perioperative risk stratification. Persistent limitations include small and heterogeneous datasets, insufficient external validation, and unresolved concerns related to data privacy, algorithmic interpretability, and medico-legal responsibility. Conclusions: Artificial intelligence is progressively emerging as a promising tool in gastric cancer surgery, integrating automation, advanced analytics, and human clinical reasoning. Its safe and ethical adoption requires robust validation, transparent governance, and continuous surgeon oversight. When developed within human-centered and ethically grounded frameworks, AI can augment, rather than replace, surgical expertise, potentially advancing precision, safety, and equity in oncologic care. Full article

Osteosarcoma, the most prevalent primary malignant bone tumor in children and adolescents, is characterized by high rates of metastasis, recurrence, and chemotherapy resistance, leading to suboptimal patient survival. The MDM2-p53 pathway plays a pivotal role in its tumorigenesis and progression, where dysregulation leads to loss of p53 function. This review systematically elucidates the molecular mechanisms of this pathway and summarizes diverse targeted therapeutic strategies, including small-molecule MDM2 inhibitors, mutant p53 reactivators, and innovative modalities such as gene therapy and Proteolysis Targeting Chimeras (PROTACs). Despite demonstrating potent preclinical activity with low IC₅₀ values, the clinical translation of these agents has faced significant challenges. Early-generation MDM2 inhibitors (e.g., RG7112, Idasanutlin) showed limited monotherapy efficacy and dose-limiting toxicities like thrombocytopenia, halting their development at early-phase clinical trials. In contrast, novel MDM2 inhibitors like APG-115 have advanced to Phase II trials, marking a significant breakthrough. Although not yet tested in dedicated osteosarcoma cohorts, their safety and efficacy in MDM2-amplified solid tumors provide a critical foundation for the development of precision medicine and combination regimens for osteosarcoma. Future efforts to accelerate drug development may leverage single-cell sequencing and AI-aided drug design to decipher osteosarcoma heterogeneity and optimize drug profiles for reduced toxicity. Full article

Background/Objectives: Large language models (LLMs) are increasingly used as decision support tools in clinical nutrition, including meal planning for individuals with type 2 diabetes mellitus (T2DM). However, the clinical safety, quantitative accuracy, and guideline adherence of AI-generated dietary plans remain uncertain. This study aimed to evaluate systematic bias and agreement between LLM-generated diets and a guideline-concordant reference diet, and to assess whether current LLMs can function as reliable clinical nutrition decision support tools in T2DM. Methods: Six widely used LLMs generated standardized three-day, 1800 kcal dietary plans for T2DM using an identical prompt. Each day was treated as an independent observation (n = 18). Energy and macronutrient contents were analyzed using professional nutrition software and compared with a dietitian-designed reference diet based on ADA, EASD, IDF, and national guidelines. Agreement was evaluated using Bland–Altman analysis, proportional bias assessment, and intraclass correlation coefficients. Guideline adherence and clinical appropriateness were independently scored by registered dietitians. Results: Most LLM-generated diets systematically deviated from the reference diet, with lower total energy, reduced carbohydrate and fiber content, and variable protein distribution. Bland–Altman analyses demonstrated significant bias and wide limits of agreement for key nutrients, indicating clinically meaningful discrepancies. Guideline adherence scores varied substantially across models, with only one model showing relatively consistent performance. Inter-rater reliability between dietitians was high (ICC = 0.806). Conclusions: Current LLMs exhibit systematic quantitative bias and inconsistent guideline adherence when used for T2DM meal planning. AI-generated dietary plans are not interchangeable with dietitian-guided medical nutrition therapy and may pose clinical risks if used without professional oversight. Careful validation, domain-specific fine-tuning, and integration within supervised clinical workflows are required before implementation in diabetes care. Full article

Given the global aging of the population and the rising retirement age, the development of cross-generational technologies is crucial for a sustainable workforce supply. While AI-powered smart glasses can provide continuous cognitive support, current industrial solutions often prioritize work efficiency at the expense of the physical, cognitive, and socio-emotional needs of older workers. This study employed a mixed-methods approach grounded in embodied cognition. First, semi-structured interviews with ten participants were analyzed using grounded theory to develop a four-dimensional model of embodied experience: Perceived Pressure, Action Feedback, Collaboration Embedding, and Belonging. Subsequently, four interaction strategies—Rhythm Control, Transparent Feedback, Non-intrusive Assistance, and Legible Privacy & Social Signaling—were formulated and implemented. A high-fidelity prototype was developed to embody these strategies. Finally, a team of eight multidisciplinary experts evaluated the device using the System Usability Scale (SUS) and a proprietary twelve-item questionnaire. The results showed that the device’s overall usability was borderline acceptable (SUS = 68.13 ± 8.94). While the devices received stronger ratings for Control & Safety, the ratings for dignity and social acceptance were comparatively low. These findings contribute to the development of wearable device operation strategies suitable for users of different generations, and underline the importance of social and emotional compatibility as a prerequisite for future practice tests. Full article

Scientific evidence is fundamental to uncovering insights about health, including food and nutritional claims. Substantiating such claims requires robust scientific procedures that often include clinical studies, biochemical analyses, and the examination of multiple forms of data. The growing capabilities of artificial intelligence (AI) and large language models (LLMs) present new opportunities for analyzing food–health relationships and supporting health claim validation. Yet, applying these technologies to the food and nutrition domain raises challenges that differ from those encountered in broader biomedical text mining (TM). In this perspective, we review key issues, including the complexity and heterogeneity of food-related data, the scarcity of food-specific language models and standardized resources, difficulties in interpreting nuanced and often contradictory evidence, and requirements for integrating AI tools into regulatory workflows. We compare modern LLM approaches with traditional TM methods and discuss how each may complement the other. Our position is that, despite their promise, current AI and LLM tools cannot yet reliably handle the subtleties of food–health evidence without substantial domain-specific refinement and human expert oversight. We advocate for hybrid approaches that combine the precision of established TM techniques with the analytical breadth of LLMs, supported by harmonized ontologies, multidimensional evaluation frameworks, and human-in-the-loop validation, particularly in regulatory contexts. We also highlight the importance of public education, transparent communication standards, and coordinated cross-disciplinary efforts to ensure these technologies serve broader goals of food safety, consumer trust, and global health. Full article

The increasing impact of climate change and resource scarcity demands energy-efficient and resource-conserving manufacturing strategies. Metal forming offers substantial potential for lightweight construction and material efficiency. Forming-induced ductile damage, particularly void nucleation and growth, is often neglected in component design. Industrial practice still relies mainly on macroscopic mechanical properties and safety factors, while microstructural damage evolution and its influence on fatigue performance are largely disregarded. This study investigates load-path-dependent fatigue behavior and damage mechanisms using axial and combined axial–torsional fatigue tests. Particular attention is given to the phase shift d between axial and torsional loading, which strongly affects fatigue life. The results indicate that axial loading dominates damage evolution, while load path interactions significantly change fatigue performance. A phase shift of d = 90° resulted in a significant increase in the number of cycles to failure, N_f, for different total strain amplitudes with the same rotational angle amplitude of θ = 10°. These findings highlight the importance of considering load-path-sensitive stress states in fatigue assessment of formed components. Fractographic analyses, AI-assisted 3D reconstruction, and confocal laser scanning microscopy support the experimental results. Full article

Background: Esophagectomy remains a technically demanding oncologic procedure with substantial morbidity, despite ongoing advances in minimally invasive and robotic techniques. Limitations in intraoperative visualization and anatomical recognition contribute to complications such as nerve injury and bleeding. Artificial intelligence (AI)-based intraoperative video analysis has emerged as a potential adjunct to enhance surgical perception and safety, but its application in esophagectomy has not been comprehensively reviewed. Methods: A systematic review was conducted in accordance with PRISMA guidelines. PubMed, Scopus, and Web of Science were searched without a lower date limit to identify eligible studies published up to January 2026, capturing early and contemporary applications of intraoperative AI in esophagectomy. Human studies involving any surgical approach were included. Data on the AI task, methodology, validation strategy, performance metrics, and reported clinical outcomes was extracted. Risk of bias was assessed using the ROBINS-I tool. Results: Six studies met the inclusion criteria, predominantly evaluating AI-driven analysis of intraoperative video during minimally invasive or robotic esophagectomy. Reported applications included real-time anatomical structure recognition, recurrent laryngeal nerve segmentation, detection of excessive nerve traction, instrument and event recognition, and surgical phase identification. Across studies, AI systems demonstrated performance comparable to expert surgeons for selected tasks and achieved real-time or near–real-time inference. One study reported earlier detection of excessive recurrent laryngeal nerve traction compared to conventional nerve integrity monitoring. However, most studies were retrospective, single-center, and feasibility-focused, with limited external validation and minimal assessment of patient-centered clinical outcomes. Conclusions: Artificial intelligence-based intraoperative analysis in esophagectomy is increasingly achievable and may enhance anatomical recognition, intraoperative risk detection, and procedural awareness. Nevertheless, current evidence remains preliminary, heterogeneous, and largely exploratory. Prospective, multicenter studies with standardized reporting and clinically meaningful outcome evaluation are required before routine implementation. Until such data is available, AI should be regarded as a complementary intraoperative tool rather than a standalone clinical decision-making system. Full article

Carbon fibre reinforced polymers (CFRPs) are increasingly used in biomedical and safety-critical applications, where embedded and real-time non-destructive testing (NDT) is essential to ensure structural integrity. This paper presents a cost-effective, AI-assisted thermographic inspection system designed from an embedded electronics and circuit-level perspective. The proposed platform integrates a long-wave infrared (LWIR) sensor, dedicated signal conditioning and power management circuits, and a Raspberry Pi-based processing unit within a unified hardware–software co-design approach. Infrared data acquired under surface heating conditions are processed on-board using a convolutional neural network based on a U-Net architecture, enabling automatic localisation and classification of subsurface defects in CFRP samples. Particular attention is devoted to embedded design constraints, including sensor interfacing, acquisition timing, end-to-end latency, and real-time processing scalability. Experimental results confirm the feasibility of real-time surface heat assessment and the robustness of the proposed architecture in detecting delaminations and voids. The presented system contributes to the development of intelligent embedded inspection electronics and provides a reference design for edge AI-enabled NDT systems in industrial and biomedical applications. Full article

Product waste in grocery supply chains remains a major concern for multiple stakeholders, particularly retailers, due to the direct financial losses it generates and the potential risks it poses to customer health and safety. In this context, digital technologies—especially artificial intelligence (AI)—offer promising opportunities to improve retail performance and reduce waste. Accordingly, this study aims to investigate the factors influencing retailers’ intentions to adopt AI-based solutions for product waste reduction. To achieve this objective, the Technology Acceptance Model (TAM) was extended by incorporating three additional constructs (i.e., perceived ethical responsibility, product waste reduction-related knowledge, and perceived economic utility of AI for product waste reduction). Data were collected from a purposive sample of 214 grocery retailers operating in major cities in northern Algeria. Structural Equation Modeling (SEM) was employed to test the proposed research model and hypotheses. The results indicate that retailers’ behavioral intentions to use AI for product waste reduction are significantly influenced by perceived economic utility of AI, AI for product waste reduction-related knowledge, perceived usefulness, and perceived ease of use. In contrast, perceived ethical responsibility for product waste reduction did not exhibit a statistically significant effect, although its relationship with behavioral intention was positive. This study contributes to the growing literature on AI adoption for waste reduction in the retail sector, particularly within developing country contexts, and offers practical insights for policymakers and industry stakeholders seeking to promote the adoption of digital technologies for sustainable supply chain management. Full article

Organ-on-a-chip (OoC) technologies, also termed microphysiological systems (MPSs), integrate microfluidics, engineered biomaterials, human-derived cells, and on-chip biosensing to model human physiology in microscale devices that deliver quantitative, time-resolved readouts. This review surveys the 2010–2025 literature, emphasizing how sensing, standardized sampling, and analytics enable clinical concordance and fit-for-purpose regulatory use. We synthesize advances in (i) materials, fabrication, and microfluidic design; (ii) organ- and disease-focused case studies; and (iii) translational benchmarks that align chip outputs with clinical pharmacokinetics, toxicology, and biomarker datasets. Across organ systems, platforms increasingly incorporate vascularization, immune components, and organoid hybrids, paired with real-time measurements of barrier integrity, metabolism, electrophysiology, and secreted biomarkers using impedance (TEER), electrochemical, and optical modalities. Representative benchmarking studies report cardiac OoCs achieving AUROC ≥ 0.85 for torsadogenic risk classification, and renal chips improving prediction of transporter-mediated clearance relative to conventional in vitro assays. We summarize validation approaches and regulatory developments relevant to new approach methodologies, including the FDA Modernization Act 2.0, and discuss how AI and multi-omics can automate signal and image analysis, harmonize cross-platform datasets, and support digital-twin workflows that couple OoC measurements to in silico models. Overall, biosensor-enabled OoCs are progressing toward quantitatively benchmarked platforms for safety pharmacology, ADME/PK–PD, and precision medicine. Full article

Value investing remains grounded in intrinsic value estimation, margin-of-safety reasoning, and disciplined fundamental analysis, but its practical execution is increasingly constrained by the scale, heterogeneity, and velocity of modern financial information. Recent advances in artificial intelligence (AI), particularly large language models and automated information-extraction systems, create new opportunities to accelerate financial analysis; however, their outputs remain probabilistic, context-dependent, and potentially error-prone, making governance and verification essential. This article proposes an AI-assisted value investing framework that integrates automated extraction, valuation modeling, explainability, and human-in-the-loop (HITL) supervision into a unified decision-support architecture. The framework is organized into three layers: (i) a data layer for traceable extraction and normalization of structured and unstructured financial information; (ii) a modeling layer for automated key performance indicator (KPI) computation, forecasting support, and discounted cash flow (DCF) valuation; and (iii) an explainability and governance layer for traceability, verification, model-risk control, and analyst oversight. A central contribution of the paper is the operational characterization of prompt literacy as a determinant of analytical reliability, showing that structured, context-aware prompts materially affect extraction correctness, usability, and verification effort. The framework is evaluated through a case study using Rivanna AI on three large U.S. beverage firms—namely, The Coca-Cola Company, PepsiCo, and Keurig Dr Pepper—selected as a controlled, information-rich setting for comparative analysis. The results indicate that the proposed workflow can reduce end-to-end analysis time from approximately 25–40 h in a traditional manual process to approximately 8–12 h in an AI-assisted setting, including citation/source verification, unit and period reconciliation, and review of key valuation assumptions. Rather than eliminating analyst effort, AI shifts it from manual information processing toward verification, adjudication, and interpretation. Overall, the findings position AI not as an autonomous decision-maker, but as a governed reasoning accelerator whose effectiveness depends on structured human guidance, traceability, and disciplined validation. In value investing, a discipline traditionally grounded in labor-intensive fundamental analysis and disciplined intrinsic value estimation, AI introduces the potential to scale analytical coverage and accelerate evidence synthesis. However, AI systems in financial contexts are probabilistic, context-sensitive, and inherently dependent on human interaction, raising critical questions about reliability, governance, and operational integration. This article proposes a structured framework for AI-driven value investing that preserves the foundational principles of intrinsic value, margin of safety, and economic reasoning, while redesigning the analytical workflow through automation, explainability, and human-in-the-loop (HITL) supervision. The proposed architecture integrates three layers: (i) an AI-enabled data layer for traceable extraction and normalization of structured and unstructured financial information; (ii) a modeling and valuation layer combining automated KPI computation, machine learning forecasting, and discounted cash flow (DCF) valuation; and (iii) an explainability and governance layer ensuring traceability, verification, and model risk control. A central contribution of this work is the operational characterization of prompt literacy, namely the ability to formulate structured, context-aware requests to AI systems, as a critical determinant of system reliability and analytical correctness. Through a focused case study using an AI-assisted analysis platform (Rivanna AI) on three U.S. beverage firms, we provide evidence that structured prompt formulation can improve extraction consistency, reduce verification overhead, and increase workflow efficiency in a human-supervised setting. In this setting, analysis time decreased from a manual range of approximately 25–40 h to 8–12 h with AI assistance and HITL validation, while preserving traceability and decision accountability. The reported hour savings should be interpreted as conservative estimates from the initial deployment phase; additional efficiency gains are expected as operational maturity increases, driven by learning-economy effects. The findings position AI not as an autonomous decision-maker but as a probabilistic reasoning accelerator whose effectiveness depends on structured human guidance, verification discipline, and prompt-driven interaction. These results redefine the role of the financial analyst from manual data processor to reasoning architect, responsible for designing, guiding, and validating AI-assisted analytical workflows. Full article

Smart city decision systems must balance conflicting objectives including efficiency, sustainability, equity, safety, and public accountability. Existing AI and reinforcement learning approaches often optimize isolated objectives and rarely provide integrated mechanisms for sustainability alignment, transparency, and pre-deployment validation. This paper introduces MORL-SGF, a governance-aware framework that integrates ESG/SDG-aligned multi-objective reinforcement learning, Digital Twin (DT)-based policy validation, and Pareto-based policy auditing within a single learning pipeline. The framework preserves vector-valued rewards to avoid hidden scalarization bias and supports auditable policy selection from a portfolio of Pareto-optimal candidates. MORL-SGF is validated analytically and conceptually through formal modeling and structured evidence synthesis rather than empirical deployment, providing a blueprint for subsequent simulation-based and real-world implementation studies. Future work will focus on large-scale Digital Twin benchmarking, stakeholder preference modeling, and deployment-oriented evaluation. Full article