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Article

4 Citations

2,196 Views

22 Pages

Gender-Specific Renoprotective Pathways in αMUPA Transgenic Mice Subjected to Acute Kidney Injury

Heba Abd Alkhaleq,
Shadi Hamoud,
Israel Hacker,
Tony Karram,
Ahmad Fokra,
Aviva Kabala and
Zaid Abassi

Int. J. Mol. Sci.2024, 25(6), 3544;https://doi.org/10.3390/ijms25063544

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21 March 2024

Acute kidney injury (AKI) is a serious health concern with high morbidity and high mortality worldwide. Recently, sexual dimorphism has become increasingly recognized as a factor influencing the severity of the disease. This study explores the gender...

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Article

2 Citations

2,179 Views

26 Pages

The Protective Pathways Activated in Kidneys of αMUPA Transgenic Mice Following Ischemia\Reperfusion-Induced Acute Kidney Injury

Heba Abd Alkhaleq,
Tony Karram,
Ahmad Fokra,
Shadi Hamoud,
Aviva Kabala and
Zaid Abassi

Cells2023, 12(20), 2497;https://doi.org/10.3390/cells12202497

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20 October 2023

Despite the high prevalence of acute kidney injury (AKI), the therapeutic approaches for AKI are disappointing. This deficiency stems from the poor understanding of the pathogenesis of AKI. Recent studies demonstrate that αMUPA, alpha murine ur...

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Article

1 Citations

1,838 Views

21 Pages

Potential Nephroprotective Effect of uPA against Ischemia/Reperfusion-Induced Acute Kidney Injury in αMUPA Mice and HEK-293 Cells

Heba Abd Alkhaleq,
Israel Hacker,
Tony Karram,
Shadi Hamoud,
Aviva Kabala and
Zaid Abassi

Biomedicines2024, 12(10), 2323;https://doi.org/10.3390/biomedicines12102323

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12 October 2024

Background/Objectives: The incidence of acute kidney injury (AKI) has been steadily increasing. Despite its high prevalence, there is no pathogenetically rational therapy for AKI. This deficiency stems from the poor understanding of the pathogenesis...

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