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Authors = Zoltán Péter Zomborszki

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10 pages, 838 KiB  
Article
The Effect of Wheatgrass Lyophilizate on Blood Clotting Time in Rats
by István Takács, Melinda Urkon, Tivadar Kiss, Edina Horváth, Eszter Laczkó-Zöld, Zoltán Péter Zomborszki, Anita Lukács, Gábor Oszlánczi, Dezső Csupor and Andrea Szabó
Sci. Pharm. 2021, 89(3), 39; https://doi.org/10.3390/scipharm89030039 - 20 Aug 2021
Cited by 1 | Viewed by 8060
Abstract
Wheatgrass is widely used in the alternative medicine, however, there is a lack of clinical evidence to support its efficacy. Although based on its chemical composition, data from animal experiments and clinical trials, the use of juice and extracts of Triticum shoots seems [...] Read more.
Wheatgrass is widely used in the alternative medicine, however, there is a lack of clinical evidence to support its efficacy. Although based on its chemical composition, data from animal experiments and clinical trials, the use of juice and extracts of Triticum shoots seems to be safe, clinical reports point out its potential interaction with oral anticoagulants. The aim of our study was to assess the interaction of wheatgrass with warfarin in rats and to assess its flavonoid content. Three groups of animals were treated orally with wheatgrass, warfarin, or the combination of wheatgrass and warfarin for five days. Clotting assays were performed using platelet-poor plasma. Prothrombin time was determined by optical and mechanical coagulometers. Flavonoid content of wheatgrass was measured by HPLC. The effect of wheatgrass on prothrombin time was not confirmed. Co-administration of wheatgrass and warfarin did not result in diminished anticoagulant activity. Low amount of flavonoids was detected in wheatgrass juice, the total flavonoid content was 0.467 mg/100 g lyophilized juice powder. The previously reported rutin, quercetin and apigenin was not detected by us. Our results do not confirm the probability of interaction of wheatgrass with oral anticoagulants. However, the low flavonoid content of wheatgrass does not support its use as an antioxidant. Full article
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8 pages, 435 KiB  
Article
Cerebrosides and Steroids from the Edible Mushroom Meripilus giganteus with Antioxidant Potential
by András Sárközy, Zoltán Béni, Miklós Dékány, Zoltán Péter Zomborszki, Kinga Rudolf, Viktor Papp, Judit Hohmann and Attila Ványolós
Molecules 2020, 25(6), 1395; https://doi.org/10.3390/molecules25061395 - 19 Mar 2020
Cited by 10 | Viewed by 3931
Abstract
The detailed chemical analysis of the methanol extract of Meripilus giganteus (Pers.) P. Karst. led to the isolation of two new cerebrosides, mericeramides A (1) and B (2) together with cerebroside B (3), ergosterol (4), [...] Read more.
The detailed chemical analysis of the methanol extract of Meripilus giganteus (Pers.) P. Karst. led to the isolation of two new cerebrosides, mericeramides A (1) and B (2) together with cerebroside B (3), ergosterol (4), 3β-hydroxyergosta-7,22-diene (5), cerevisterol (6), 3β-hydroxyergosta-6,8(14),22-triene (7), 3β-O-glucopyranosyl-5,8-epidioxyergosta-6,22-diene (8) and (11E,13E)-9,10-dihydroxy-11,13-octadecadienoic acid (9). The structures of the compounds were determined on the basis of NMR and MS spectroscopic analysis. Mericeramide A (1) is the first representative of halogenated natural cerebrosides. The isolated fungal metabolites 1–9 were evaluated for their antioxidant activity using the oxygen radical absorbance capacity (ORAC) assay. Compounds 2, 5 and 9 proved to possess considerable antioxidant effects, with 2.50 ± 0.29, 4.94 ± 0.37 and 4.27 ± 0.05 mmol TE/g values, respectively. The result obtained gives a notable addition to the chemical and bioactivity profile of M. giganteus, highlighting the possible contribution of this species to a versatile and balanced diet. Full article
(This article belongs to the Section Natural Products Chemistry)
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12 pages, 1010 KiB  
Article
Synthesis and In Vitro Antitumor Activity of Naringenin Oxime and Oxime Ether Derivatives
by Ahmed Dhahir Latif, Tímea Gonda, Máté Vágvölgyi, Norbert Kúsz, Ágnes Kulmány, Imre Ocsovszki, Zoltán Péter Zomborszki, István Zupkó and Attila Hunyadi
Int. J. Mol. Sci. 2019, 20(9), 2184; https://doi.org/10.3390/ijms20092184 - 2 May 2019
Cited by 32 | Viewed by 5599
Abstract
Naringenin is one of the most abundant dietary flavonoids exerting several beneficial biological activities. Synthetic modification of naringenin is of continuous interest. During this study our aim was to synthesize a compound library of oxime and oxime ether derivatives of naringenin, and to [...] Read more.
Naringenin is one of the most abundant dietary flavonoids exerting several beneficial biological activities. Synthetic modification of naringenin is of continuous interest. During this study our aim was to synthesize a compound library of oxime and oxime ether derivatives of naringenin, and to investigate their biological activities. Two oximes and five oxime ether derivatives were prepared; their structure has been elucidated by NMR and high-resolution mass spectroscopy. The antiproliferative activity of the prepared compounds was evaluated by MTT assay against human leukemia (HL-60) and gynecological cancer cell lines isolated from cervical (HeLa, Siha) and breast (MCF-7, MDA-MB-231) cancers. Tert-butyl oxime ether derivative exerted the most potent cell growth inhibitory activity. Moreover, cell cycle analysis suggested that this derivative caused a significant increase in the hypodiploid (subG1) phase and induced apoptosis in Hela and Siha cells, and induced cell cycle arrest at G2/M phase in MCF-7 cells. The proapoptotic potential of the selected compound was confirmed by the activation of caspase-3. Antioxidant activities of the prepared molecules were also evaluated with xanthine oxidase, DPPH and ORAC assays, and the methyl substituted oxime ether exerted the most promising activity. Full article
(This article belongs to the Special Issue Bioactive Phytochemicals for Cancer Prevention and Treatment)
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14 pages, 1214 KiB  
Article
Chemo-Diversity and Antiradical Potential of Twelve Matricaria chamomilla L. Populations from Iran: Proof of Ecological Effects
by Elahe Piri, Mohammad Mahmoodi Sourestani, Esmaeil Khaleghi, Javad Mottaghipisheh, Zoltán Péter Zomborszki, Judit Hohmann and Dezső Csupor
Molecules 2019, 24(7), 1315; https://doi.org/10.3390/molecules24071315 - 3 Apr 2019
Cited by 40 | Viewed by 4732
Abstract
Matricaria chamomilla L. is a popular medicinal herb that is used for healing various diseases and is widely distributed worldwide in temperate climate zones, and even in the subtropical climate of Southern and Western Iran. This study was aimed at comparing the volatile [...] Read more.
Matricaria chamomilla L. is a popular medicinal herb that is used for healing various diseases and is widely distributed worldwide in temperate climate zones, and even in the subtropical climate of Southern and Western Iran. This study was aimed at comparing the volatile oil constituents, along with antiradical potential and HPLC analysis of methanolic extracts from twelve plant samples growing in Iran. The present research was carried out for the first time on these populations. Among seventeen identified volatile chemicals evaluated by GC/MS and GC/FID, representing 92.73–97.71% of the total oils, α-bisabolone oxide A (45.64–65.41%) was the major constituent, except in case of “Sarableh” as a new chemotype, where (E)- and (Z)-γ-bisabolene (42.76 and 40.08%, respectively) were the predominant components. Oxygenated sesquiterpenes (53.31–74.52%) were the most abundant compounds in the samples excluding “Sarableh” with 91.3% sesquiterpene hydrocarbons. “Sarableh” also exerted the most potent antioxidant capacity with EC50 = 7.76 ± 0.3 µg/mL and 6.51 ± 0.63 mmol TE (Trolox® equivalents)/g. In addition, populations “Lali” and “Bagh Malek” contained the highest amounts of apigenin and luteolin with 1.19 ± 0.01 mg/g and 2.20 ± 0.0 mg/g of plant material, respectively. Our findings depict a clear correlation between phytochemical profiles and antiradical potential of M. chamomilla and geographical factors. Full article
(This article belongs to the Collection Qualitative and Quantitative Analysis of Bioactive Natural Products)
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8 pages, 444 KiB  
Article
Bioactivity-Guided Isolation of Antimicrobial and Antioxidant Metabolites from the Mushroom Tapinella atrotomentosa
by Zoltán Béni, Miklós Dékány, Bernadett Kovács, Boglárka Csupor-Löffler, Zoltán Péter Zomborszki, Erika Kerekes, András Szekeres, Edit Urbán, Judit Hohmann and Attila Ványolós
Molecules 2018, 23(5), 1082; https://doi.org/10.3390/molecules23051082 - 4 May 2018
Cited by 34 | Viewed by 6635
Abstract
Bioassay-guided fractionation of the chloroform extract of Tapinella atrotomentosa led to the isolation of four secondary metabolites 1–4. Two of the compounds are lactones—osmundalactone (1) and 5-hydroxy-hex-2-en-4-olide (2)—while 3 and 4 were identified as terphenyl quinones, [...] Read more.
Bioassay-guided fractionation of the chloroform extract of Tapinella atrotomentosa led to the isolation of four secondary metabolites 1–4. Two of the compounds are lactones—osmundalactone (1) and 5-hydroxy-hex-2-en-4-olide (2)—while 3 and 4 were identified as terphenyl quinones, spiromentins C and B, respectively. The structures of the compounds were established on the basis of NMR and MS spectroscopic analysis. The isolated fungal metabolites were evaluated for their antibacterial activities against several Gram-positive and negative bacteria. In addition, their synergistic effect with cefuroxime against methicillin-resistant Staphylococcus aureus (MRSA) was also evaluated. Compounds 1–3 proved to possess significant antibacterial activity against multiresistant Acinetobacter baumannii and extended-spectrum β-lactamase (ESBL)-producing Escherichia coli. The investigation of the antioxidant effect of the isolated compounds in DPPH and ORAC assays revealed that spiromentins C (3) and B (4) have remarkable antioxidant activity. Full article
(This article belongs to the Collection Phytochemicals: Biosynthesis, Metabolism and Biological Activities)
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