Search Results (31)

This review aimed to assess the effectiveness of interventions used to minimize barriers to participation in physical activity (PA) among adolescents. This systematic literature review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 guidelines. Searches were conducted across five databases: PubMed, SPORTDiscus, Embase, Scopus, and Web of Science. Thirty-four studies evaluated interventions to overcome barriers to participation in PA, with a focus on lack of motivation, encouragement, and support, as well as intrapersonal, interpersonal, and environmental barriers. Most interventions were conducted in developed countries, with an emphasis on girls, reflecting efforts to address health inequities. The interventions, conducted in schools, included workshops, training programs, lectures, goal setting, and practical activities, lasting from four weeks to four years. Twenty-seven studies (79.4%) reported positive impacts on PA participation, particularly in interventions addressing psychosocial, psychological, and behavioral barriers. The most effective interventions combined theory (through educational approaches) and practice (practical PA activities). These findings contribute to understanding barriers leading to physical inactivity and provide insights for developing or replicating initiatives to improve PA levels among adolescents. Full article

Unconventional food plants, popularized in Brazil as PANC, remain underutilized globally. In that sense, this study aims to explore the nutritional and functional properties of taioba (Xanthosoma sagittifolium), a plant with edible leaves and tubers, and to investigate its potential for industrial-scale application as a source of starch. A systematic review was carried out and meta-analysis following the PRISMA guidelines was conducted based on a random effects synthesis of multivariable-adjusted relative risks (RRs). The searches were carried out in seven search sources, among which were Web of Science, Elsevier’s Science Direct, Wiley Online Library, Springer Nature, Taylor & Francis, Hindawi, Scielo, ACS—American Chemical Society, and Google Scholar. The systematic review was guided by a systematic review protocol based on the POT strategy (Population, Outcome, and Types of studies), adapted for use in this research. Mendeley was a resource used for organization, to manage references, and to exclude duplicates of studies selected for review. The findings revealed that taioba leaves are abundant in essential nutrients, proteins, vitamins, and minerals. Additionally, the tubers offer rich starch content along with vitamins and minerals like iron, potassium, and calcium, making them an ideal substitute for conventional sources on an industrial scale. This research highlights the significance of studying the functionalities, applicability, and integration of this PANC in our diets, while also emphasizing its capability as a substitute for traditional starch varieties. Moreover, exploiting this plant’s potential adds value to Amazonian resources, reduces import costs, and diversifies resource utilization across multiple industrial sectors. Full article

Cognitive restructuring (CR) aims to get people to challenge and modify their cognitive distortions, generating alternative, more adaptive thoughts. Behavioral, emotional, and physiological responses are modified by analyzing and changing dysfunctional thoughts. The person must have the cognitive capacity to participate in the analysis of their thoughts. CR for people with depression has positive effects, although there is little research on how it should be structured and applied. CR is a thought modification technique presented in the Nursing Interventions Classification (NIC), but is not organized in a sequential approach, and there is no procedure for applying it in practice. This scoping review aims to identify the structure, contents and assessment instruments used in CR for people with depressive symptoms and to analyze the health outcomes of applying the CR technique in this population. Out of 515 articles, seven studies were included in the review, up to 2021 and without any time limitation. The studies were not guided by a consistent and sound framework of the CR technique and each study used its own framework, although they used similar techniques. We grouped CR into six steps. No specific studies were found regarding intervention by nurses. CR is effective in reducing depressive symptoms, so it is an important therapeutic tool that should be used on people with depression. With this scoping review, mental health nurses will have a more comprehensive idea of the techniques that can be used in the application of CR to patients with depressive symptoms. Full article

Dermatophytes associated with bacteria can lead to severe, difficult-to-treat infections and contribute to chronic infections. Trichophyton rubrum, Staphylococcus aureus, and Staphylococcus epidermidis can form biofilms influenced by nutrient availability. This study investigated biofilm formation by these species by utilizing diverse culture media and different time points. These biofilms were studied through scanning electron microscopy (SEM), confocal laser scanning microscopy (CLSM), biomass, metabolic activity, and colony-forming units (CFUs). The results revealed that mixed biofilms exhibited high biomass and metabolic activity when cultivated in the brain heart infusion (BHI) medium. Both bacterial species formed mature biofilms with T. rubrum within 72 h, irrespective of media. The timing of bacterial inoculation was pivotal in influencing biomass and metabolic activity. T. rubrum’s development within mixed biofilms depended on bacterial addition timing, while pre-adhesion influenced fungal growth. Bacterial communities prevailed initially, while fungi dominated later in the mixed biofilms. CLSM revealed 363 μm thick T. rubrum biofilms with septate, well-developed hyphae; S. aureus (177 μm) and S. epidermidis (178 μm) biofilms showed primarily cocci. Mixed biofilms matched T. rubrum’s thickness when associated with S. epidermidis (369 μm), with few hyphae initially. Understanding T. rubrum and Staphylococcal interactions in biofilms advances antimicrobial resistance and disease progression knowledge. Full article

Background: Behçet’s disease (BD) is a rare chronic auto-inflammatory systemic disease with non-specific oral manifestations, categorised as generalised variable vessel vasculitis that requires an interdisciplinary approach to diagnose due to its phenotypic heterogeneity. Whilst the oral lesions that reoccur in BD underpin the complex diagnostic process, the crucial role of dental professionals is highlighted in a case report summarised herein. We present a case of a 47-year-old male referred to the Oral Medicine Department by a rheumatologist after previous hospitalization for thrombosis of the iliac vein and inferior vena cava. He had elevated inflammatory C-reactive protein biomarker and an increased erythrocyte sedimentation rate. Recurrent episodes of folliculitis, oral and genital ulcers were reported. Clinical examination revealed multiple ulcerations in the oral mucosa. The complementary, histopathological analysis performed to rule out other disorders, based on excisional biopsy, showed non-keratinised stratified squamous epithelium with areas of exocytosis and ulceration. The connective tissue presented an intense mixed inflammatory infiltrate, congested blood vessels, haemorrhage, vasculitis, and HLA-B genotyping identified the expression of HLA-B15, further supporting the BD diagnosis. Treatment was initiated with colchicine, prednisolone, and weekly subcutaneous administration of methotrexate and resulted in the complete remission of oral lesions and no recurrence of other manifestations. Conclusions: This BD case report emphasizes the importance of a multidisciplinary approach in diagnosing BD, including the use of histopathological assessment and genetic profiling. It highlights the significance of thorough intraoral assessment and referral to a multidisciplinary team for diagnosis. The oral manifestations of BD as the primary symptoms often indicate underlying major systemic pathologies. The authors stress the need for a structured diagnostic algorithm to facilitate timely and effective management of BD. Full article

Pereskia aculeata Miller, is an unconventional food plant native to South America. This study aimed to investigate the influence of different ultrasonic extraction times (10, 20, 30, and 40 min) on the phytochemical profile, antioxidant and antibacterial activities of ethanolic extracts obtained from lyophilized Pereskia aculeate Miller (ora-pro-nobis) leaves, an under-researched plant. Morphological structure and chemical group evaluations were also conducted for the lyophilized P. aculeate leaves. The different extraction times resulted in distinct phenolic content and Antioxidant Activity (ATT) values. Different extraction time conditions resulted in phenolic compound contents ranging from 2.07 to 2.60 mg EAG.g⁻¹ of extract and different ATT values. The ATT evaluated by DPPH was significantly higher (from 61.20 to 70.20 μM of TE.g⁻¹ of extract) in extraction times of 30 and 40 min, respectively. For ABTS, it varied between 6.38 and 10.24 μM of TE.g⁻¹ of extract and 24.34 and 32.12 μM ferrous sulp.g⁻¹ of extract. All of the obtained extracts inhibited the growth of Staphylococcus aureus, particularly the treatment employing 20 min of extraction at the highest dilution (1.56 mg.mL⁻¹). Although liquid chromatography analyses showed that chlorogenic acid was the primary compound detected for all extracts, Paper Spray Mass Spectrometry (PS-MS) suggested the extracts contained 53 substances, such as organic, fatty, and phenolic acids, sugars, flavonoids, terpenes, phytosterols, and other components. The PS-MS proved to be a valuable technique to obtain the P. aculeate leaves extract chemical profile. It was observed that the freeze-drying process enhanced the conservation of morphological structures of P. aculeate leaves, as evidenced by scanning electron microscopy (SEM). Fourier transform infrared spectroscopy (FTIR) identified carboxyl functional groups and proteins between the 1000 and 1500 cm⁻¹ bands in the P. aculeate leaves, thus favoring water interaction and contributing to gel formation. To the best of our knowledge, this is the first study to evaluate different times (10, 20, 30 and 40 min) for ultrasound extraction of P. aculeate leaves. The polyphenols improved extraction, and high antioxidant activity demonstrates the potential for applying P. aculeate leaves and their extract as functional ingredients or additives in the food and pharmaceutical industries. Full article

Human land use land cover changes (LULCCs) can cause impacts on watershed lands and on water resources. The regions with land use conflict suffer more intense erosion processes due to their high slope and drainage density. The study intends to evaluate scenarios with an absence of land use conflict and verify if it can contribute to reductions in surface runoff, avoiding the carriage of tailings to river channels. In the study, the SWAT model was used in the hydrological modeling of the Paraopeba River watershed affected by the rupture. The results show that the SWAT model was able to reproduce the flow data with good and very good performances. The quality indicators in the calibration step were NSE = 0.66, R² = 0.69, PBIAS = 5.2%, and RSR = 0.59, and in the validation, step were NSE = 0.74, R² = 0.77, PBIAS = 13.5%, and RSR = 0.51. The LULCC from 2000 to 2019 led to a 70% increase in lateral runoff (LATQ) and a 74% decrease in aquifer groundwater. The scenario of land use capability and no conflict can reduce lateral runoff by 37% and increase water infiltration by 265%, minimizing the point and diffuse contamination of the tailings in the Paraopeba river channel. Full article

N–acetyl–L–cysteine (NAC), a derivative of the L–cysteine amino acid, presents antioxidant and mucolytic properties of pharmaceutical interest. This work reports the preparation of organic-inorganic nanophases aiming for the development of drug delivery systems based on NAC intercalation into layered double hydroxides (LDH) of zinc–aluminum (Zn₂Al–NAC) and magnesium–aluminum (Mg₂Al–NAC) compositions. A detailed characterization of the synthesized hybrid materials was performed, including X-ray diffraction (XRD) and pair distribution function (PDF) analysis, infrared and Raman spectroscopies, solid-state ¹³carbon and ²⁷aluminum nuclear magnetic resonance (NMR), simultaneous thermogravimetric and differential scanning calorimetry coupled to mass spectrometry (TG/DSC–MS), scanning electron microscopy (SEM), and elemental chemical analysis to assess both chemical composition and structure of the samples. The experimental conditions allowed to isolate Zn₂Al–NAC nanomaterial with good crystallinity and a loading capacity of 27.3 (m/m)%. On the other hand, NAC intercalation was not successful into Mg₂Al–LDH, being oxidized instead. In vitro drug delivery kinetic studies were performed using cylindrical tablets of Zn₂Al–NAC in a simulated physiological solution (extracellular matrix) to investigate the release profile. After 96 h, the tablet was analyzed by micro-Raman spectroscopy. NAC was replaced by anions such as hydrogen phosphate by a slow diffusion-controlled ion exchange process. Zn₂Al–NAC fulfil basic requirements to be employed as a drug delivery system with a defined microscopic structure, appreciable loading capacity, and allowing a controlled release of NAC. Full article

An infectious disease caused by SARS-CoV-2, COVID-19 greatly affects the pediatric population and is 3 times more prevalent in newborns than in the general population. In newborns, the overexpression of immunological molecules may also induce a so-called cytokine storm. In our study, we evaluated the expression of cytokines in newborns admitted to a neonatal ICU whose mothers had SARS-CoV-2 and symptoms of SARS. The blood of newborns of infected and healthy mothers was collected to identify their Th1 and Th2 cytokine profiles, and via flow cytometry, the cytokines TNF-α, IFN-γ, IL-2, IL-6, and IL-10 were identified. Overexpression was observed in the Th1 and Th2 cytokine profiles of newborns from infected mothers compared with the control group. Statistical analysis also revealed significant differences between the cellular and humoral responses of the infected group versus the control group. The cellular versus humoral responses of the newborns of infected mothers were also compared, which revealed the prevalence of the cellular immune response. These data demonstrate that some cytokines identified relate to more severe symptoms and even some comorbidities. IL-6, TNF-α, and IL-10 may especially be related to cytokine storms in neonates of mothers with COVID-19. Full article

The culture of açaí (Euterpe oleraceae M.), originating from floodplain areas, was planted on dry land in many properties in Pará, Brazil, making necessary the use of irrigation. To irrigate adequately with less waste, it is necessary that studies aim at increasing efficiency in the use of water in this sector, and one of the ways to do so is to estimate evapotranspiration (ET). The objective of this study was to estimate the actual daily evapotranspiration using the Surface Energy Balance Algorithm for Land (SEBAL) in eastern Amazonia. Six images from the Landsat 8 satellite were used, and the estimates of evapotranspiration with the SEBAL algorithm showed good agreement with the results obtained by the Bowen ratio method in the area of açaí planting, including the mean absolute error (MAE), mean relative error (MRE), root of mean square error (RMSE), and the concordance index (d index) equal to 0.45 mm day⁻¹, 4.23%, 0.52 mm day⁻¹, and 0.80, respectively. SEBAL showed the ability to distinguish the soil cover, demonstrating the sensitivity of the model, which provided the mapping of the components analyzed. The use of the algorithm helps in decision making regarding irrigation management and reducing costs and water losses. Full article

The development of biomaterials has a substantial role in pharmaceutical and medical strategies for the enhancement of life quality. This review work focused on versatile biomaterials based on nanocomposites comprising organic polymers and a class of layered inorganic nanoparticles, aiming for drug delivery (oral, transdermal, and ocular delivery) and tissue engineering (skin and bone therapies). Layered double hydroxides (LDHs) are 2D nanomaterials that can intercalate anionic bioactive species between the layers. The layers can hold metal cations that confer intrinsic biological activity to LDHs as well as biocompatibility. The intercalation of bioactive species between the layers allows the formation of drug delivery systems with elevated loading capacity and modified release profiles promoted by ion exchange and/or solubilization. The capacity of tissue integration, antigenicity, and stimulation of collagen formation, among other beneficial characteristics of LDH, have been observed by in vivo assays. The association between the properties of biocompatible polymers and LDH-drug nanohybrids produces multifunctional nanocomposites compatible with living matter. Such nanocomposites are stimuli-responsive, show appropriate mechanical properties, and can be prepared by creative methods that allow a fine-tuning of drug release. They are processed in the end form of films, beads, gels, monoliths etc., to reach orientated therapeutic applications. Several studies attest to the higher performance of polymer/LDH-drug nanocomposite compared to the LDH-drug hybrid or the free drug. Full article

The description of this clinical nursing intervention reaffirms the therapeutic potential of art therapy in the promotion of mental health in a psychiatric setting. Ten patients participated. An intervention plan was developed based on the nursing process methodology, using the nursing ontology approved by the Portuguese Order of Nurses. The nursing diagnoses related to the intervention group were identified. The aims and the planning of the art therapy sessions were delineated, and, in addition, the assessment strategies. We concluded that art therapy promoted the relationship between the nurse and the therapeutic group, with positive results in self-concept and mood balance. Full article

Clinical supervision has been incorporated into health policies in response to concerns about client safety and quality of care. The objective of the study was to analyze the perception of a nurse manager on the contribution of clinical supervision to the quality and safety of care. Qualitative, exploratory study, data collection was conducted through semi-structured interviews with a nurse manager. Data analysis is according to Bardin. The following subcategories emerged from the analysis: quality of practices; care safety; quality standards. Subcategories were aggregated in the categories Guarantee of Quality and Safety Standards of Care. Full article

This case study aims to describe the implementation of the decision-making process in mental health nursing given the care needs identified in a person with Alzheimer’s disease at home. The cognitive assessment, supported by the cognitive decision algorithm, revealed that the patient presented moderate dementia, with visuospatial disorganization, memory changes, orientation, evocation, and constructive abilities. Five sessions of cognitive stimulation were performed to enhance cognitive functions and their maintenance. We concluded that the personalized nursing intervention allowed for stabilizing mental health conditions. Full article

Nursing finds the basis for its action in research. The main purpose of research is to discover how to improve nursing care. Nurses are required to provide quality care based on the latest scientific evidence. We expect higher education institutions to develop scientific research; therefore, there seems to be a close relationship between research and teaching. Reconciling these two dimensions is not an easy task. This study demonstrates the close relationship between research and teaching. However, it also highlights some constraints related to the small number of full-time researchers and the difficulty reconciling research and teaching. Full article