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Authors = Lisa F.P. Ng

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36 pages, 3246 KB  
Review
Insights into Antibody-Mediated Alphavirus Immunity and Vaccine Development Landscape
by Anthony Torres-Ruesta, Rhonda Sin-Ling Chee and Lisa F.P. Ng
Microorganisms 2021, 9(5), 899; https://doi.org/10.3390/microorganisms9050899 - 22 Apr 2021
Cited by 13 | Viewed by 6214
Abstract
Alphaviruses are mosquito-borne pathogens distributed worldwide in tropical and temperate areas causing a wide range of symptoms ranging from inflammatory arthritis-like manifestations to the induction of encephalitis in humans. Historically, large outbreaks in susceptible populations have been recorded followed by the development of [...] Read more.
Alphaviruses are mosquito-borne pathogens distributed worldwide in tropical and temperate areas causing a wide range of symptoms ranging from inflammatory arthritis-like manifestations to the induction of encephalitis in humans. Historically, large outbreaks in susceptible populations have been recorded followed by the development of protective long-lasting antibody responses suggesting a potential advantageous role for a vaccine. Although the current understanding of alphavirus antibody-mediated immunity has been mainly gathered in natural and experimental settings of chikungunya virus (CHIKV) infection, little is known about the humoral responses triggered by other emerging alphaviruses. This knowledge is needed to improve serology-based diagnostic tests and the development of highly effective cross-protective vaccines. Here, we review the role of antibody-mediated immunity upon arthritogenic and neurotropic alphavirus infections, and the current research efforts for the development of vaccines as a tool to control future alphavirus outbreaks. Full article
(This article belongs to the Special Issue Emerging Alphaviruses)
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18 pages, 634 KB  
Review
Fast Tracks and Roadblocks for Zika Vaccines
by Khairunnisa Abdul Ghaffar, Lisa F.P. Ng and Laurent Renia
Vaccines 2018, 6(4), 77; https://doi.org/10.3390/vaccines6040077 - 21 Nov 2018
Cited by 10 | Viewed by 7494
Abstract
In early 2014, a relatively obscure virus, the Zika virus, made headlines worldwide following an increase in the number of congenital malformations. Since then, research on Zika virus, treatment and vaccines have progressed swiftly with various drugs being repurposed and vaccines heading into [...] Read more.
In early 2014, a relatively obscure virus, the Zika virus, made headlines worldwide following an increase in the number of congenital malformations. Since then, research on Zika virus, treatment and vaccines have progressed swiftly with various drugs being repurposed and vaccines heading into clinical trials. Nonetheless, the need for a vaccine is crucial in order to eradicate this re-emerging arthropod-borne virus which remained silent since its first discovery in 1947. In this review, we focused on how the inconspicuous virus managed to spread, the key immunological factors required for a vaccine and the various vaccine platforms that are currently being studied. Full article
(This article belongs to the Special Issue Development of Vaccines against Zika Virus)
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