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Vaccines 2018, 6(4), 77;

Fast Tracks and Roadblocks for Zika Vaccines

Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Singapore 138648, Singapore
Institute of Infection and Global Health, University of Liverpool, Liverpool L69 7BE, UK
Author to whom correspondence should be addressed.
Received: 28 October 2018 / Revised: 16 November 2018 / Accepted: 20 November 2018 / Published: 21 November 2018
(This article belongs to the Special Issue Development of Vaccines against Zika Virus)
PDF [634 KB, uploaded 22 November 2018]


In early 2014, a relatively obscure virus, the Zika virus, made headlines worldwide following an increase in the number of congenital malformations. Since then, research on Zika virus, treatment and vaccines have progressed swiftly with various drugs being repurposed and vaccines heading into clinical trials. Nonetheless, the need for a vaccine is crucial in order to eradicate this re-emerging arthropod-borne virus which remained silent since its first discovery in 1947. In this review, we focused on how the inconspicuous virus managed to spread, the key immunological factors required for a vaccine and the various vaccine platforms that are currently being studied. View Full-Text
Keywords: Zika virus; vaccine; immune responses; delivery systems Zika virus; vaccine; immune responses; delivery systems

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Ghaffar, K.A.; Ng, L.F.; Renia, L. Fast Tracks and Roadblocks for Zika Vaccines. Vaccines 2018, 6, 77.

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