Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 

Saved Queries

Sign in to use this feature.

Search Filter Reset All

Years

Between: -

Subjects

remove_circle_outline
remove_circle_outline
remove_circle_outline
Add Subjects Reset
Select Subjects

Journals

remove_circle_outline
remove_circle_outline
remove_circle_outline
Add Journals Reset
Select Journals

Article Types

remove_circle_outline
remove_circle_outline
Add Article Types Reset
Select Article Types

Countries / Regions

remove_circle_outline
remove_circle_outline
remove_circle_outline
Add Countries / Regions Reset
Select Countries / Regions
Update Search
share announcement

Search Results (5)

Search Parameters:
Authors = Ilya A. Shutkov

Order results
Result details
Results per page
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
21 pages, 3347 KiB  
Article
Antiproliferative Water-Soluble Mono- and Binuclear Ruthenium Complexes with Pyridone–Imidazole Ligands
by Ilya A. Shutkov, Nikolai A. Melnichuk, Sofya A. Ovakimyan, Dmitrii M. Mazur, Nataliya E. Borisova, Maxim L. Kuznetsov, Ivan A. Godovikov, Konstantin A. Lyssenko, Dmitrii S. Yakovlev, Alexander A. Spasov, Elena R. Milaeva and Alexey A. Nazarov
Int. J. Mol. Sci. 2025, 26(11), 5214; https://doi.org/10.3390/ijms26115214 - 29 May 2025
Viewed by 462
Abstract
In this study, we synthesized and characterized new imidazole ligands containing pyridone groups, as well as mononuclear and binuclear ruthenium complexes, which are a new class of water-soluble metallacycles. We studied the antiproliferative activity of these compounds in vitro using the MTT assay [...] Read more.
In this study, we synthesized and characterized new imidazole ligands containing pyridone groups, as well as mononuclear and binuclear ruthenium complexes, which are a new class of water-soluble metallacycles. We studied the antiproliferative activity of these compounds in vitro using the MTT assay on a panel of human cancer cell lines and on primary rat fibroblasts, where we observed a complete absence of cytotoxicity up to a concentration of 1000 µM. For the binuclear metallocycle compounds, we investigated their solubility in water, resistance to hydrolysis, and ability to induce apoptosis in tumor cells. Full article
(This article belongs to the Section Biochemistry)
►▼ Show Figures

Graphical abstract

5 pages, 860 KiB  
Short Note
Di-µ-(1-(3-(1H-imidazol-1-yl)propyl)-2-methyl-4-oxo-1,4-dihydropyridin-3-olate)-bis[(η5-pentamethylcyclopentadienyl)iridium(III)] Chloride
by Ilya A. Shutkov, Nikolai A. Melnichuk, Konstantin A. Lyssenko, Nataliya E. Borisova, Olga N. Kovaleva and Alexey A. Nazarov
Molbank 2024, 2024(2), M1816; https://doi.org/10.3390/M1816 - 5 May 2024
Cited by 1 | Viewed by 1888
Abstract
A metallacyclic maltol-tethered organometallic Ir(III) half-sandwich complex was synthesized as an analog of the ruthenium anticancer complexes (RAPTA/RAED) to evaluate its in vitro antiproliferative activity against various human cancer cell lines. Full article
(This article belongs to the Section Organic Synthesis and Biosynthesis)
►▼ Show Figures

Figure 1

18 pages, 7144 KiB  
Article
New Organometallic Ru(II) Compounds with Lonidamine Motif as Antitumor Agents
by Ilya A. Shutkov, Yulia N. Okulova, Dmitrii M. Mazur, Nikolai A. Melnichuk, Denis A. Babkov, Elena V. Sokolova, Alexander A. Spasov, Elena R. Milaeva and Alexey A. Nazarov
Pharmaceutics 2023, 15(5), 1366; https://doi.org/10.3390/pharmaceutics15051366 - 29 Apr 2023
Cited by 8 | Viewed by 2056
Abstract
The combination of one molecule of organic and metal-based fragments that exhibit antitumor activity is a modern approach in the search for new promising drugs. In this work, biologically active ligands based on lonidamine (a selective inhibitor of aerobic glycolysis used in clinical [...] Read more.
The combination of one molecule of organic and metal-based fragments that exhibit antitumor activity is a modern approach in the search for new promising drugs. In this work, biologically active ligands based on lonidamine (a selective inhibitor of aerobic glycolysis used in clinical practice) were introduced into the structure of an antitumor organometallic ruthenium scaffold. Resistant to ligand exchange reactions, compounds were prepared by replacing labile ligands with stable ones. Moreover, cationic complexes containing two lonidamine-based ligands were obtained. Antiproliferative activity was studied in vitro by MTT assays. It was shown that the increase in the stability in ligand exchange reactions does not influence cytotoxicity. At the same time, the introduction of the second lonidamine fragment approximately doubles the cytotoxicity of studied complexes. The ability to induce apoptosis and caspase activation in tumour cell MCF7 was studied by employing flow cytometry. Full article
(This article belongs to the Special Issue Beyond the Platinum in Metal-Based Cancer Therapy, 2nd Edition)
►▼ Show Figures

Figure 1

4 pages, 780 KiB  
Short Note
Dichloro[N-[(η6-phenyl)methyl]-4-(1-(3,5,5,8,8-pentamethyl-5,6,7,8tetrahydronaphthalen-2-yl)vinyl)benzamide](1,3,5-triaza-7-phosphatricyclo [3.3.1.13,7]decane-κP7)ruthenium
by Ilya A. Shutkov, Dmitrii M. Mazur, Nataliya E. Borisova, Elena R. Milaeva and Alexey A. Nazarov
Molbank 2022, 2022(4), M1506; https://doi.org/10.3390/M1506 - 25 Nov 2022
Cited by 1 | Viewed by 1662
Abstract
Bexarotene-tethered RuII(arene) compounds with 1,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane (PTA) were prepared as an analog of RAPTA antitumor complexes in order to evaluate their in vitro antiproliferative activity against human cancer cell lines. Full article
(This article belongs to the Section Organic Synthesis and Biosynthesis)
►▼ Show Figures

Figure 1

18 pages, 36738 KiB  
Article
Ru(III) Complexes with Lonidamine-Modified Ligands
by Ilya A. Shutkov, Yulia N. Okulova, Vladimir Yu. Tyurin, Elena V. Sokolova, Denis A. Babkov, Alexander A. Spasov, Yulia A. Gracheva, Claudia Schmidt, Kirill I. Kirsanov, Alexander A. Shtil, Olga M. Redkozubova, Elena F. Shevtsova, Elena R. Milaeva, Ingo Ott and Alexey A. Nazarov
Int. J. Mol. Sci. 2021, 22(24), 13468; https://doi.org/10.3390/ijms222413468 - 15 Dec 2021
Cited by 16 | Viewed by 5950
Abstract
A series of bifunctional Ru(III) complexes with lonidamine-modified ligands (lonidamine is a selective inhibitor of aerobic glycolysis in cancer cells) was described. Redox properties of Ru(III) complexes were characterized by cyclic voltammetry. An easy reduction suggested a perspective for these agents as their [...] Read more.
A series of bifunctional Ru(III) complexes with lonidamine-modified ligands (lonidamine is a selective inhibitor of aerobic glycolysis in cancer cells) was described. Redox properties of Ru(III) complexes were characterized by cyclic voltammetry. An easy reduction suggested a perspective for these agents as their whole mechanism of action seems to be based on activation by metal atom reduction. New compounds demonstrated a more pronounced antiproliferative potency than the parental drug; individual new agents were more cytotoxic than cisplatin. Stability studies showed an increase in the stability of complexes along with the linker length. A similar trend was noted for antiproliferative activity, cellular uptake, apoptosis induction, and thioredoxin reductase inhibition. Finally, at concentrations that did not alter water solubility, the selected new complex evoked no acute toxicity in Balb/c mice. Full article
(This article belongs to the Special Issue 25th Anniversary of IJMS: Advances in Biochemistry)
►▼ Show Figures

Graphical abstract

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying article 1-50 on page 1 of 1.
Back to TopTop