Search Results (93)

To determine the long-term effect of Australian bushfires on the upper tropospheric composition in the South Pacific, we investigated the variation in CO and hydrocarbon species in the South Pacific according to the extent of Australian bushfires (2004–2020). We conducted analyses using satellite data on hydrocarbon and CO from the Atmospheric Chemistry Experiment Fourier Transform Spectrometer (ACE-FTS), and on fire (fire count, burned area, and fire radiative power) from the Moderate Resolution Imaging Spectroradiometer (MODIS). Additionally, we compared the effects of bushfires between Northern and Southeastern Australia (N_Aus and SE_Aus, respectively). Our analyses show that Australian bushfires in austral spring (September to November) result in the largest increase in CO and hydrocarbon species in the South Pacific and even in the west of South America, indicating the trans-Pacific transport of smoke plumes. In addition to HCN (a well-known wildfire indicator), CO and other hydrocarbon species (C₂H₂, C₂H₆, CH₃OH, HCOOH) are also considerably increased by Australian bushfires. A unique finding in this study is that the hydrocarbon increase in the South Pacific mostly relates to the bushfires in N_Aus, implying that we need to be more vigilant of bushfires in N_Aus, although the severe Australian bushfire in 2019–2020 occurred in SE_Aus. Due to the surface conditions in springtime, bushfires on grassland in N_Aus during this time account for most Australian bushfires. All results show that satellite data enables us to assess the long-term effect of bushfires on the air composition over remote areas not having surface monitoring platforms. Full article

Background/Objectives: Early-onset cancer is an emerging global health concern, including in the United States. However, data on early-onset liver and intrahepatic bile duct cancer remain limited. This study aims to fill this gap by analyzing trends in early-onset liver and intrahepatic bile duct cancer in the United States over the past two decades. Methods: This study used National Childhood Cancer Registry data to examine temporal trends in early-onset liver and intrahepatic bile duct cancer in the United States. The analysis involved estimating age-adjusted incidence rates of early-onset liver and intrahepatic bile duct cancer, stratified by histological type, ethnicity, and sex. Results: In 2021, the age-adjusted incidence rate of early-onset liver and intrahepatic bile duct cancer was estimated at 0.53 per 100,000 population (95% Confidence Interval [CI]: 0.48–0.59). From 2001 to 2021, the age-adjusted incidence rate showed a significant annual percent change (APC) of 1.35% (95% CI: 0.87–1.83%). When stratified by sex, the age-adjusted incidence rate in females increased significantly (APC: 3.07%, 95% CI: 2.26–3.87%) while remaining stable in males. Among racial and ethnic groups, non-Hispanic American Indian and Alaska Native (AIAN) individuals had the highest age-adjusted incidence rate, recorded at 2.67 per 100,000 population (95% CI: 0.95–5.85). By histological type, hepatic carcinoma had the highest age-adjusted incidence rate, significantly increasing over time (APC: 1.47%, 95% CI: 0.96–1.99%). In contrast, the incidence rates for hepatoblastoma and unspecified hepatic tumors remained stable between 2001 and 2021. Conclusions: Our study identified an increasing incidence of early-onset liver and intrahepatic bile duct cancer in the United States, primarily driven by cases in females and hepatic carcinoma. Full article

Background/Objectives: The incidence and mortality of early-onset cancers have been rising in recent decades. While epidemiological studies have examined various types of cancer, updated global data on alcohol-attributable primary liver cancer (PLC) in young adults remains limited. Methods: This study utilized data from the Global Burden of Disease (GBD) study spanning 2000 to 2021 to evaluate the age-standardized incidence, mortality, and corresponding rates of alcohol-attributable PLC among young adults aged 15–49 years. Results: In 2021, there were 8290 incidence cases and 6590 deaths from alcohol-attributable PLC in young adults. The age-standardized incidence rate has increased in Europe (annual percent change [APC]: 0.44%, 95%CI 0.35 to 0.54%), Southeast Asia (APC: 0.40%, 95% CI 0.37 to 0.44%), and the Western Pacific region (APC: 0.65%, 95% CI 0.44 to 0.86%). In 2021, alcohol-attributable PLC in young adults represented 11% (+2% from 2000) of incident cases and 11% of (+2% from 2000) deaths among all PLC in young adults. About half of the countries showed an increase in the age-standardized incidence rate of alcohol-attributable PLC among young adults between 2000 and 2021. Conclusions: The incidence rate of alcohol-attributable liver cancer in young adults has shifted significantly over the past two decades, with notable increases in Europe and the Asia–Pacific region. This trend underscores the need for global strategies to address the rising prevalence of alcohol use disorder and alcohol-associated liver disease and their impact on young adults. Full article

Titanium (Ti) and its alloys are used in various applications, including aircraft frames, ship parts, heat exchangers, and evaporator tubes, because of their extraordinary properties, such as high specific strength, excellent corrosion resistance at high temperatures, good castability, and weldability. Plastic deformation plays a crucial role in securing the appropriate microstructure and strength of Ti and alloys in these applications. The rolling process, one of the most useful methods for plastic deformation, causes efficient deformation inside the materials, resulting in grain refinement, dislocation slip, and twinning. Recent studies on the rolling behaviors of Ti and its alloys have explored their crystallographic and mechanical properties. These investigations primarily analyzed the microstructural changes and their influence on the mechanical properties under different temperatures and rolling methods. This study elucidates a complex relationship between the processing conditions and the resulting properties. Therefore, this paper presents a comprehensive review of the state-of-the-art Ti rolling. Various key aspects for verifying the microstructure of Ti and its alloys are discussed, including electron backscatter diffraction analysis, Schmidt factor, and misorientation distribution. Full article

This study investigated the effects of acupuncture and warm acupuncture on the expression and mechanism of the AMP-activated protein kinase (AMPK) signalling pathway associated with lipid accumulation in the liver tissue of rats with metabolic dysfunction-associated fatty liver disease (MAFLD) induced by a high-fat diet. Sprague–Dawley rats were categorised into four groups: control (CON), untreated MAFLD (MAFLD), and two MAFLD groups treated with acupuncture (ACU) and warm acupuncture (WA). The treatment groups underwent 16 application sessions over 8 weeks at the SP9 and BL18 acupoints. We measured the expression levels of AMPK, sterol regulatory element-binding protein1 (SREBP1), acetyl-coenzyme A carboxylase (ACC), peroxisome proliferator-activated receptorα (PPARα), carnitine palmitoyltransferase1 (CPT1), and CPT2. AMPK was activated in both ACU and WA groups. WA downregulated both SREBP1 and ACC expression at the protein level, whereas the acupuncture treatment downregulated SREBP1 expression. Additionally, WA selectively induced the activation of signalling pathways related to AMPK, PPARα, CPT1, and CPT2 at the mRNA level. Histological observations confirmed that fat accumulation was reduced in both the ACU and the WA groups compared to the MAFLD group. The WA treatment-promoted amelioration of HFD-induced MAFLD may be related to the activation of the AMPK/SREBP1/ACC pathway in the liver. Full article

Whole-spine radiography can be accomplished through two methods: (1) segmented imaging employing X-ray tube angulation and detectors, or (2) the Euronext Paris Advanced Orthopedic Solutions (EOS) 2D Imaging system that can capture the entire spine in a single image using X-ray tubes and detectors oriented at a 90-degree angle. This study aimed to establish optimal EOS examination parameters based on patient morphotype and scan speed to reduce patient radiation exposure, repeat examinations, heat stress on equipment, and X-ray tube cooling time. X-ray exposure conditions involved adjustments of scan speed ranging from two to four steps, contingent upon the patient’s morphotype (‘S’, small body; ‘M’, medium body; and ‘L’, large body. Patient dose measurements were conducted 20 times for each set of conditions. When transitioning from an ‘S’ to an ‘M’ morphotype at a constant scan speed, the entrance skin dose (ESD) exhibited an increase of approximately 41.25 ± 4.57%. A similar change from an ‘M’ to an ‘L’ morphotype resulted in an ESD increase of roughly 59.56 ± 24.00%. A transition from an ‘S’ to an ‘L’ morphotype at the same scan speed manifested an ESD elevation of approximately 124.21 ± 26.96%. This study underscores significant variations in radiation dose, ranging from 40% to 50%, when altering morphotype while maintaining a consistent scan speed. Full article

Orthotospovirus tomatomaculae (tomato spotted wilt virus, TSWV) is transmitted by the western flower thrips, Frankliniella occidentalis. Epoxyoctadecamonoenoic acids (EpOMEs) function as immune-suppressive factors, particularly in insects infected by viral pathogens. These oxylipins are produced by cytochrome P450 monooxygenases (CYPs) and are degraded by soluble epoxide hydrolase (sEH). In this study, we tested the hypothesis that TSWV modulates the EpOME level in the thrips to suppress antiviral responses and enhance its replication. TSWV infection significantly elevated both 9,10-EpOME and 12,13-EpOME levels. Following TSWV infection, the larvae displayed apoptosis in the midgut along with the upregulated expression of four caspase genes. However, the addition of EpOME to the viral treatment notably reduced apoptosis and downregulated caspase gene expressions, which led to a marked increase in TSWV titers. The CYP and sEH genes of F. occidentalis were identified, and their expression manipulation using RNA interference (RNAi) treatments led to significant alternations in the insect’s immune responses and TSWV viral titers. To ascertain which viral factor influences the host EpOME levels, specialized RNAi treatments targeting genes encoded by TSWV were administered to larvae infected with TSWV. These treatments demonstrated that NS_S expression is pivotal in manipulating the genes involved in EpOME metabolism. These results indicate that NSs of TSWV are crucially linked with the elevation of host insect EpOME levels and play a key role in suppressing the antiviral responses of F. occidentalis. Full article

This study developed and validated a machine learning model to accurately predict acute kidney injury (AKI) after non-cardiac surgery, aiming to improve patient outcomes by assessing its clinical feasibility and generalizability. We conducted a retrospective cohort study using data from 76,032 adults who underwent non-cardiac surgery at a single tertiary medical center between March 2019 and February 2021, and used data from 5512 patients from the VitalDB open dataset for external model validation. The predictive variables for model training consisted of demographic, preoperative laboratory, and intraoperative data, including calculated statistical values such as the minimum, maximum, and mean intraoperative blood pressure. When predicting postoperative AKI, our gradient boosting machine model incorporating all the variables achieved the best results, with AUROC values of 0.868 and 0.757 for the internal and external validations using the VitalDB dataset, respectively. The model using intraoperative data performed best in internal validation, while the model with preoperative data excelled in external validation. In this study, we developed a predictive model for postoperative AKI in adult patients undergoing non-cardiac surgery using preoperative and intraoperative data, and external validation demonstrated the efficacy of open datasets for generalization in medical artificial modeling research. Full article

The aim of this study is to explore the multidimensional relationships among factors influencing decision-making processes regarding women’s willingness to marry and childbirth in South Korea with recognizing the context of family development in East Asian cultures. To this end, we employed three different analytical approaches, including classification tree modeling, Cox proportional hazard modeling, and permutation feature importance evaluation. Leveraging longitudinal data specific to Korean women, we highlighted the significance of socio-economic factors in family development dynamics. Our findings revealed that financial stability played a crucial role. Unmarried women’s willingness to marry was influenced by their perspectives on economic stability, while households’ consumption capacity and financial capability determined childbirth decisions and timing. We observed a trend of postponed marriage among women in their marriageable age range, particularly those with stable economic situations, reflecting a prevalent trend of skepticism of marriage in Korean society. Additional findings related to values, cultural factors, and personal happiness also suggested the challenges that discourage younger generations from entering into marriage and starting families in South Korea. By offering insights into these dynamics, our study provides practical implications for addressing the obstacles faced, contributing to a better understanding of family development dynamics. Full article

Pralidoxime chloride, a highly hydrophilic antidote, cannot be effectively separated by reverse-phase high-performance liquid chromatography (RP-HPLC), unless the mobile-phase composition is varied. However, the use of ion-pairing reagents for pralidoxime separation is hindered by the persistent contamination of the stationary phase or chromatography system inside the HPLC system. Thus, this study aimed to develop a simple, rapid, and robust method based on RP-HPLC to determine pralidoxime chloride in antidote autoinjectors using a chaotropic salt as the mobile-phase additive. The use of UV detection at 270 nm allowed for the simultaneous detection of pralidoxime chloride and the internal standard, pyridine-2-aldoxime. The addition of chaotropic salts (NaPF₆, NaBF₄, and NaClO₄) and an ionic liquid ([EMIM]PF₆) increased the retention time of pralidoxime chloride. Among them, NaPF₆ exhibited the highest capacity factor in the reverse-phase C18 column. Increasing the salt concentration increased the capacity factor and the number of theoretical plates. Analytical method validation was performed to assess the linearity, accuracy, precision, recovery, and repeatability, according to the Ministry of Food and Drug Safety guidelines. Additionally, this newly developed method exhibits an adequate separation capability, making it a potential substitute for the current method employed in the United States/Korean Pharmacopoeia, and it ensures the necessary durability to maintain the robustness and reliability of the analytical system. Full article

DC transformers have emerged as essential devices for medium voltage DC (MVDC)-low voltage DC (LVDC) distribution systems. However, conventional step-down single-level converters have limits on the voltage level of the MVDC-LVDC distribution system. This paper proposes a non-isolated step-down (NISD) DC transformer based on discontinuous conduction mode (DCM). The proposed structure can withstand high voltage levels by sharing voltages between energy storage modules dividing voltage levels. The proposed NISD DC transformer determines operational modes based on energy storage modules and performs the voltage conversion process. The effectiveness of the proposed NISD DC transformer is verified based on a case study using a power system computer-aided design and electromagnetic transient simulation engine including DC (PSCAD/EMTDC™). Full article

An important part of regenerative endodontic procedures involving immature permanent teeth is the regeneration of the pulp–dentin complex with continuous root development. Hydraulic calcium silicate cements (HCSCs) are introduced for the pulpal treatment of immature permanent teeth. The stem-cell-derived secretome recently has been applied for the treatment of various damaged tissues. Here, we evaluated the biocompatibility and osteogenic differentiation of HCSCs combined with secretome on human dental pulp stem cells. In the Cell Counting Kit-8 test and wound healing assays, significantly higher cell viability was observed with secretome application. In alkaline phosphatase analysis, the activity was significantly higher with secretome application in all groups, except for RetroMTA on day 2 and Endocem MTA Premixed on day 4. In an Alizarin Red S staining analysis, all groups with secretome application had significantly higher staining values. Quantitative real-time polymerase chain reaction results showed that the day 7 expression of OSX significantly increased with secretome application in all groups. SMAD1 and DSPP expression also increased significantly with secretome addition in all groups except for Biodentine. In conclusion, HCSCs showed favorable biocompatibility and osteogenic ability and are predicted to demonstrate greater synergy with the addition of secretome during regenerative endodontic procedures involving immature permanent teeth. Full article

Metabolic dysfunction-associated steatotic liver disease (MASLD) affects more than 30% of the world’s adult population. While it is associated with obesity and metabolic syndrome, emerging evidence has shown that a substantial number of MASLD patients have a normal body mass index (“lean individuals with MASLD”). In this article, we provide an overview of the definition, epidemiology, pathogenesis, and clinical outcomes associated with lean individuals with MASLD and updates on current management. Full article

The measurement of biosignals in the clinical and healthcare fields is fundamental; however, conventional electrodes pose challenges such as incomplete skin contact and skin-related issues, hindering accurate biosignal measurement. To address these challenges, conductive hydrogels, which are valuable owing to their biocompatibility and flexibility, have been widely developed and explored for electrode applications. In this study, we fabricated a conductive hydrogel by mixing polyethylene glycol diacrylate (PEGDA) with poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) polymers dissolved in deionized water, followed by light-triggered crosslinking. Notably, this study pioneered the use of a PEGDA−PEDOT:PSS hydrogel for electrocardiogram (ECG) monitoring- a type of biosignal. The resulting PEGDA−PEDOT:PSS hydrogel demonstrated remarkable conductivity while closely approximating the modulus of skin elasticity. Additionally, it demonstrated biocompatibility and a high signal-to-noise ratio in the waveforms. This study confirmed the exceptional suitability of the PEGDA−PEDOT:PSS hydrogel for accurate biosignal measurements with potential applications in various wearable devices designed for biosignal monitoring. Full article

In this study, we aimed to assess the prevalence of interstitial lung abnormalities (ILAs) and investigate the rates and risk factors associated with radiologic ILA progression among patients with lung cancer following surgical resection. Patients who underwent surgical resection for lung cancer at our institution from January 2015 to December 2020 were retrospectively evaluated and grouped according to their ILA status as having no ILAs, equivocal ILAs, or ILAs. Progression was determined by simultaneously reviewing the baseline and corresponding follow-up computed tomography (CT) scans. Among 346 patients (median age: 67 (interquartile range: 60–74) years, 204 (59.0%) men), 22 (6.4%) had equivocal ILAs, and 33 (9.5%) had ILAs detected upon baseline CT. Notably, six patients (6/291; 2.1%) without ILAs upon baseline CT later developed ILAs, and 50% (11/22) of those with equivocal ILAs exhibited progression. Furthermore, 75.8% (25/33) of patients with ILAs upon baseline CT exhibited ILA progression (76.9% and 71.4% with fibrotic and non-fibrotic ILAs, respectively). Multivariate analysis revealed that ILA status was a significant risk factor for ILA progression. ILAs and equivocal ILAs were associated with radiologic ILA progression after surgical resection in patients with lung cancer. Hence, early ILA detection can significantly affect clinical outcomes. Full article