Search Results (9)

Accurate, high-resolution maps of bedrock outcrops can be valuable for applications such as models of land–atmosphere interactions, mineral assessments, ecosystem mapping, and hazard mapping. The increasing availability of high-resolution imagery can be coupled with machine learning techniques to improve regional bedrock outcrop maps. In the United States, the existing 30 m U.S. Geological Survey (USGS) National Land Cover Database (NLCD) tends to misestimate extents of barren land, which includes bedrock outcrops. This impacts many calculations beyond bedrock mapping, including soil carbon storage, hydrologic modeling, and erosion susceptibility. Here, we tested if a machine learning (ML) model could more accurately map exposed bedrock than NLCD across the entire Sierra Nevada Mountains (California, USA). The ML model was trained to identify pixels that are likely bedrock from 0.6 m imagery from the National Agriculture Imagery Program (NAIP). First, we labeled exposed bedrock at twenty sites covering more than 83 km² (0.13%) of the Sierra Nevada region. These labels were then used to train and test the model, which gave 83% precision and 78% recall, with a 90% overall accuracy of correctly predicting bedrock. We used the trained model to map bedrock outcrops across the entire Sierra Nevada region and compared the ML map with the NLCD map. At the twenty labeled sites, we found the NLCD barren land class, even though it includes more than just bedrock outcrops, accounted for only 41% and 40% of mapped bedrock from our labels and ML predictions, respectively. This substantial difference illustrates that ML bedrock models can have a role in improving land-cover maps, like NLCD, for a range of science applications. Full article

The Module-0 Demonstrator is a single-phase 600 kg liquid argon time projection chamber operated as a prototype for the DUNE liquid argon near detector. Based on the ArgonCube design concept, Module-0 features a novel 80k-channel pixelated charge readout and advanced high-coverage photon detection system. In this paper, we present an analysis of an eight-day data set consisting of 25 million cosmic ray events collected in the spring of 2021. We use this sample to demonstrate the imaging performance of the charge and light readout systems as well as the signal correlations between the two. We also report argon purity and detector uniformity measurements and provide comparisons to detector simulations. Full article

Minimally invasive thoracic surgery has advanced the treatment of lung cancer since its introduction in the 1990s. Video-assisted thoracoscopic surgery (VATS) and robotic-assisted thoracic surgery (RATS) offer the advantage of smaller incisions without compromising patient outcomes. These techniques have been shown to be safe and effective in standard pulmonary resections (lobectomy and sub-lobar resection) and in complex pulmonary resections (sleeve resection and pneumonectomy). Furthermore, several studies show these techniques enhance patient outcomes from early recovery to improved quality of life (QoL) and excellent oncologic results. The rise of RATS has yielded further operative benefits compared to thoracoscopic surgery. The wristed instruments, neutralization of tremor, dexterity, and magnification allow for more precise and delicate dissection of tissues and vessels. This review summarizes of the advancements in minimally invasive thoracic surgery and the positive impact on patient outcomes. Full article

The breakthrough of a limited number of clones while on immune checkpoint inhibitors (ICIs), known as oligoprogression, has been previously described. The benefit of ablative radiation therapy (RT) directed at these clones, as opposed to changing systemic therapy, is unclear. We analyzed 30 patients with advanced solid tumors, the majority of whom (23/30, 86.7%) had either hepatocellular or urothelial carcinoma, who experienced oligoprogression on ICIs and were referred for RT. In this study, oligoprogression was defined as having experienced progression at three or fewer metastatic sites outside of the brain after achieving at least stable disease on ICIs for a minimum of three months. The median time to oligoprogression was 11.1 months from the initiation of immunotherapy. 24 patients had one oligoprogressive lesion and six had two. The median radiation dose delivered was 4650 cGy in a median of five fractions. The median progression-free survival (PFS) after RT was 7.1 months, and the time to oligoprogression was not a significant predictor of PFS2. 26 patients continued on ICIs after RT. While 17 patients subsequently progressed, 15 did so at three or fewer metastatic sites and could have theoretically stood to benefit from an additional course of salvage RT to further extend the lifespan of their ICIs. Overall survival at 6, 12, and 24 months was 100.0%, 96.3%, and 82.8%, respectively. These results suggest that RT may provide a PFS benefit and extend the lifespan of ICIs in patients who experience oligoprogression. Regardless of PFS, however, overall survival in this population appears to be excellent. Full article

The Deep Underground Neutrino Experiment (DUNE) is an international, world-class experiment aimed at exploring fundamental questions about the universe that are at the forefront of astrophysics and particle physics research. DUNE will study questions pertaining to the preponderance of matter over antimatter in the early universe, the dynamics of supernovae, the subtleties of neutrino interaction physics, and a number of beyond the Standard Model topics accessible in a powerful neutrino beam. A critical component of the DUNE physics program involves the study of changes in a powerful beam of neutrinos, i.e., neutrino oscillations, as the neutrinos propagate a long distance. The experiment consists of a near detector, sited close to the source of the beam, and a far detector, sited along the beam at a large distance. This document, the DUNE Near Detector Conceptual Design Report (CDR), describes the design of the DUNE near detector and the science program that drives the design and technology choices. The goals and requirements underlying the design, along with projected performance are given. It serves as a starting point for a more detailed design that will be described in future documents. Full article

The 1999 Hector Mine earthquake ruptured to the surface in eastern California, with >5 m peak right-lateral slip on the Lavic Lake fault. The cumulative offset and geologic slip rate of this fault are not well defined, which inhibits tectonic reconstructions and risk assessment of the Eastern California Shear Zone (ECSZ). With thermal infrared hyperspectral airborne imagery, field data, and auxiliary information from legacy geologic maps, we created lithologic maps of the area using supervised and unsupervised classifications of the remote sensing imagery. We optimized a data processing sequence for supervised classifications, resulting in lithologic maps over a test area with an overall accuracy of 71 ± 1% with respect to ground-truth geologic mapping. Using all of the data and maps, we identified offset bedrock features that yield piercing points along the main Lavic Lake fault and indicate a 1036 +27/−26 m net slip, with 1008 +14/−17 m horizontal and 241 +51/−47 m vertical components. For the contribution from distributed shear, modern off-fault deformation values from another study imply a larger horizontal slip component of 1276 +18/−22 m. Within the constraints, we estimate a geologic slip rate of <4 mm/yr, which does not increase the sum geologic Mojave ECSZ rate to current geodetic values. Our result supports previous suggestions that transient tectonic activity in this area may be responsible for the discrepancy between long-term geologic and present-day geodetic rates. Full article

In September 2018, the First European Workshop on Metal Phosphonates Chemistry brought together some prominent researchers in the field of metal phosphonates and phosphinates with the aim of discussing past and current research efforts and identifying future directions. The scope of this perspective article is to provide a critical overview of the topics discussed during the workshop, which are divided into two main areas: synthesis and characterisation, and applications. In terms of synthetic methods, there has been a push towards cleaner and more efficient approaches. This has led to the introduction of high-throughput synthesis and mechanochemical synthesis. The recent success of metal–organic frameworks has also promoted renewed interest in the synthesis of porous metal phosphonates and phosphinates. Regarding characterisation, the main advances are the development of electron diffraction as a tool for crystal structure determination and the deployment of in situ characterisation techniques, which have allowed for a better understanding of reaction pathways. In terms of applications, metal phosphonates have been found to be suitable materials for several purposes: they have been employed as heterogeneous catalysts for the synthesis of fine chemicals, as solid sorbents for gas separation, notably CO₂ capture, as materials for electrochemical devices, such as fuel cells and rechargeable batteries, and as matrices for drug delivery. Full article

This study investigates the fire regime for the arid Carnarvon Basin region of Western Australia using remotely sensed imagery. A fire history database was constructed from satellite images to characterise the general fire regime and determine any effect of vegetation types and pre-fire weather and climate. The study area was divided into two sections (northern and southern) due to their inherently different vegetation and climate. A total of 23.8% (15,646 km²) of the study area was burnt during the 39-year study period. Heathland vegetation (54%) burnt the most extensively in the southern study area, and hummock grasslands (68%) in the northern. A single, unusually large fire in 2012 followed exceptional rains in the previous 12 months and accounted for 55% of the total burnt area. This fire burnt mainly through Acacia shrublands and woodlands rather than hummock grasslands, as normally experienced in the northern study area. Antecedent rainfall and fire weather were found to be the main meteorological factors driving fire size. Both study areas showed a moderate to strong correlation between fire size and increased pre-fire rainfall in the year preceding the fire. Predicted future changes in climate may lead to more frequent and higher intensity fires. Full article

Background: Timely follow-up of fecal occult blood screening with colonoscopy is essential for achieving colorectal cancer mortality reduction. In the present study, we evaluated the effectiveness of centrally generated, physician-targeted audit and feedback to improve colonoscopy uptake after a positive fecal occult blood test (fobt) result within Ontario’s population-wide ColonCancerCheck Program. Methods: This prospective cohort study used data sets from Ontario’s ColonCancerCheck Program (2008–2011) that were linked to provincial administrative health databases. Cox proportional hazards regression was used to estimate the effect of centralized, physician-targeted audit and feedback on colonoscopy uptake in an Ontario-wide fobt-positive cohort. Results: A mailed physician audit and feedback report identifying individuals outstanding for colonoscopy for 3 or more months after a positive fobt result did not increase the likelihood of colonoscopy uptake (hazard ratio: 0.95; 95% confidence interval: 0.79 to 1.13). Duration of positive fobt status was strongly inversely associated with the hazard of follow-up colonoscopy (p for linear trend: <0.001). Conclusions: In a large population-wide setting, centralized tracking in the form of physician-targeted mailed audit and feedback reports does not improve colonoscopy uptake for screening participants with a positive fobt result outstanding for 3 or more months. Mailed physician-targeted screening audit and feedback reports alone are unlikely to improve compliance with follow-up colonoscopy in Ontario. Other interventions such as physician audits or automatic referrals, demonstrated to be effective in other jurisdictions, might be warranted. Full article