Search Results (12)

This paper presents a conceptual and methodological framework for using Geographical Information Systems (GIS) to “deep map” cultural heritage sites along Ireland’s Wild Atlantic Way, with a focus on the 1588 Spanish Armada wrecks in County Kerry and archaeological landscapes in County Sligo’s “Yeats Country.” Drawing on interdisciplinary dialogues from the humanities, social sciences, and geospatial sciences, it illustrates how digital spatial technologies can excavate, preserve, and sustain intangible cultural knowledge embedded within such palimpsestic landscapes. Using MAXQDA 24 software to mine and code historical, literary, folkloric, and environmental texts, the study constructed bespoke GIS attribute tables and visualizations integrated with elevation models and open-source archaeological data. The result is a richly layered cartographic method that reveals the spectral and affective dimensions of heritage landscapes through climate, memory, literature, and spatial storytelling. By engaging with “deep mapping” and theories such as “Spectral Geography,” the research offers new avenues for sustainable heritage conservation, cultural tourism, and public education that are sensitive to both ecological and cultural resilience in the West of Ireland. Full article

Sweetpotatoes are a major crop in California, ranking sixth in value among organic commodities in the state. In recent years, there has been growing consumer interest in diverse specialty varieties, particularly purple types and those associated with Asian American and Pacific Islander (AAPI) communities, some of which are currently imported into the state. In this study, we screened 45 diverse sweetpotato varieties and breeding lines under California organic conditions in a preliminary characterization of their agronomic performance. We then conducted culinary evaluations with a tasting panel of students primarily identifying as Asian/Asian American to determine the preference for each type in terms of flavor and culinary appeal. Our results indicated that major tradeoffs exist among existing germplasm, with no variety or line excelling across all agronomic and culinary traits. These results suggest that sweetpotato breeding could be an effective mechanism to combine superior agronomic traits of major commercial classes with the high culinary quality of diverse materials that are not adapted to California organic production. These results provide a strong justification for the value of sweetpotato breeding to ultimately promote a more profitable, sustainable, and just food system in the region. Full article

Toll-interleukin receptor (TIR) domains have emerged as critical players involved in innate immune signaling in humans but are also expressed as potential virulence factors within multiple pathogenic bacteria. However, there has been a shortage of structural studies aimed at elucidating atomic resolution details with respect to their interactions, potentially owing to their dynamic nature. Here, we used a combination of biophysical and biochemical studies to reveal the dynamic behavior and functional interactions of a panel of both bacterial TIR-containing proteins and mammalian receptor TIR domains. Regarding dynamics, all three bacterial TIR domains studied here exhibited an inherent exchange that led to severe resonance line-broadening, revealing their intrinsic dynamic nature on the intermediate NMR timescale. In contrast, the three mammalian TIR domains studied here exhibited a range in terms of their dynamic exchange that spans multiple timescales. Functionally, only the bacterial TIR domains were catalytic towards the cleavage of NAD⁺, despite the conservation of the catalytic nucleophile on human TIR domains. Our development of NMR-based catalytic assays allowed us to further identify differences in product formation for gram-positive versus gram-negative bacterial TIR domains. Differences in oligomeric interactions were also revealed, whereby bacterial TIR domains self-associated solely through their attached coil-coil domains, in contrast to the mammalian TIR domains that formed homodimers and heterodimers through reactive cysteines. Finally, we provide the first atomic-resolution studies of a bacterial coil-coil domain and provide the first atomic model of the TIR domain from a human anti-inflammatory IL-1R8 protein that undergoes a slow inherent exchange. Full article

This work applies emergent self-organizing map (ESOM) techniques, a form of machine learning, in the multidimensional interpretation and prediction of rare earth element (REE) abundance in produced and geothermal waters in the United States. Visualization of the variables in the ESOM trained using the input data shows that each REE, with the exception of Eu, follows the same distribution patterns and that no single parameter appears to control their distribution. Cross-validation, using a random subsample of the starting data and only using major ions, shows that predictions are generally accurate to within an order of magnitude. Using the same approach, an abridged version of the U.S. Geological Survey Produced Waters Database, Version 2.3 (which includes both data from produced and geothermal waters) was mapped to the ESOM and predicted values were generated for samples that contained enough variables to be effectively mapped. Results show that in general, produced and geothermal waters are predicted to be enriched in REEs by an order of magnitude or more relative to seawater, with maximum predicted enrichments in excess of 1000-fold. Cartographic mapping of the resulting predictions indicates that maximum REE concentrations exceed values in seawater across the majority of geologic basins investigated and that REEs are typically spatially co-associated. The factors causing this co-association were not determined from ESOM analysis, but based on the information currently available, REE content in produced and geothermal waters is not directly controlled by lithology, reservoir temperature, or salinity. Full article

This paper explores mappings, musings and ‘thought experiments’ in literary geography to consider how they may contribute to geoethical pedagogy and research. Representations of Prometheus from the fourteenth century onwards have traveled along three broad symbological roads: first, as the creator, and bringer of fire; second as a bound figure in chains, and thirdly, unbound. However, it was the harnessing of fire by our species a millennium prior that gave rise to the myth of Prometheus and set into motion the geophysical process of combustion which “facilitated the transformation of much of the terrestrial surface […] and in the process pushed the parameters of the earth system into a new geological epoch.” As the geophysicist Professor Michael Mann observes, global warming and loss of biodiversity constitutes an ethical problem. The remediation of the Prometheus myth in Mary Shelley’s Frankenstein; or the modern Prometheus (1818), Jonathan Fetter-Vorm’s Trinity: A Graphic History of the First Atomic Bomb (2012) and William Golding’s novel Lord of the Flies (1954) provides the means to explore the geographical, historical and cultural contingencies of geoethical dilemmas contributing to the framing of the Anthropocene and Gaia heuristics. This paper argues for the necessity of scholars in the arts, humanities and geosciences to share and exchange idiographic and nomothetic perspectives in order to forge a geoethical dialectic that fuses poetic and positivistic methods into transcendent ontologies and epistemologies to address the existential questions of global warming and loss of biodiversity as we enter the age of the Anthropocene. Full article

The terrorist attacks on 11 September 2001 potentially exposed more than 400,000 responders, workers, and residents to psychological and physical stressors, and numerous hazardous pollutants. In 2011, the World Trade Center Health Program (WTCHP) was mandated to monitor and treat persons with 9/11-related adverse health conditions and conduct research on physical and mental health conditions related to the attacks. Emerging evidence suggests that persons exposed to 9/11 may be at increased risk of developing mild cognitive impairment. To investigate further, the WTCHP convened a scientific workshop that examined the natural history of cognitive aging and impairment, biomarkers in the pathway of neurodegenerative diseases, the neuropathological changes associated with hazardous exposures, and the evidence of cognitive decline and impairment in the 9/11-exposed population. Invited participants included scientists actively involved in health-effects research of 9/11-exposed persons and other at-risk populations. Attendees shared relevant research results from their respective programs and discussed several options for enhancements to research and surveillance activities, including the development of a multi-institutional collaborative research network. The goal of this report is to outline the meeting’s agenda and provide an overview of the presentation materials and group discussion. Full article

Blepharospasm and oromandibular dystonia are focal dystonias characterized by involuntary and often patterned, repetitive muscle contractions. There is a long history of medical and surgical therapies, with the current first-line therapy, botulinum neurotoxin (BoNT), becoming standard of care in 1989. This comprehensive review utilized MEDLINE and PubMed and provides an overview of the history of these focal dystonias, BoNT, and the use of toxin to treat them. We present the levels of clinical evidence for each toxin for both, focal dystonias and offer guidance for muscle and site selection as well as dosing. Full article

Cytoreductive surgery (CRS) with or without hyperthermic intraperitoneal chemotherapy (HIPEC) is associated with improved survival for patients with colorectal peritoneal metastases (CR-PM). However, the role of neoadjuvant chemotherapy (NAC) prior to CRS-HIPEC is poorly understood. A retrospective review of adult patients with CR-PM who underwent CRS+/-HIPEC from 2000–2017 was performed. Among 298 patients who underwent CRS+/-HIPEC, 196 (65.8%) received NAC while 102 (34.2%) underwent surgery first (SF). Patients who received NAC had lower peritoneal cancer index score (12.1 + 7.9 vs. 14.3 + 8.5, p = 0.034). There was no significant difference in grade III/IV complications (22.4% vs. 16.7%, p = 0.650), readmission (32.3% vs. 23.5%, p = 0.114), or 30-day mortality (1.5% vs. 2.9%, p = 0.411) between groups. NAC patients experienced longer overall survival (OS) (median 32.7 vs. 22.0 months, p = 0.044) but similar recurrence-free survival (RFS) (median 13.8 vs. 13.0 months, p = 0.456). After controlling for confounding factors, NAC was not independently associated with improved OS (OR 0.80) or RFS (OR 1.04). Among patients who underwent CRS+/-HIPEC for CR-PM, the use of NAC was associated with improved OS that did not persist on multivariable analysis. However, NAC prior to CRS+/-HIPEC was a safe and feasible strategy for CR-PM, which may aid in the appropriate selection of patients for aggressive cytoreductive surgery. Full article

Cementitious grouts are being developed for use as sealing and support matrices (SSMs) in deep borehole disposal (DBD) where temperatures do not exceed 190 °C. They will seal radioactive waste containers into the bottom 2 km of holes drilled up to 5 km deep into the crystalline basement. The temperature and pressure is likely to be similar to those in hydrocarbon and geothermal energy wells, where grout placement and durability are affected. This paper reviews the potential cementing systems suitable for this application and explains why a single solution of a formulation of Class G oil well cement, silica flour, water, fluid loss additive, and retarding admixture has been selected. This type of formulation has been used extensively for over 100 years in well cementing. It should provide the short-term performance and durability required for an SSM, maintaining the seal around the waste packages within the disposal zone long after the boreholes are sealed back to the surface, and thus augmenting the safety case for DBD. Full article

Daily undulating periodization (DUP), using daily alterations in repetitions, has been advocated as a superior method of resistance training, while traditional forms of programming for periodization (Block) have been questioned. Nineteen Division I track and field athletes were assigned to either a 10-week Block or DUP training group. Year and event were controlled. Over the course of the study, there were four testing sessions, which were used to evaluate a variety of strength characteristics, including maximum isometric strength, rate of force development, and one repetition maximum (1RM). Although, performance trends favored the Block group for strength and rate of force development, no statistical differences were found between the two groups. However, different (p ≤ 0.05) estimated volumes of work (VL) and amounts of improvement per VL were found between groups. Based upon calculated training efficiency scores, these data indicate that a Block training model is more efficient in producing strength gains than a DUP model. Additionally, alterations in testosterone (T), cortisol (C) and the T:C ratio were measured. Although there were no statistically (p ≤ 0.05) different hormone alterations between groups, relationships between training variables and hormone concentrations including the T:C ratio, indicate that Block may be more efficacious in terms of fatigue management. Full article

Human preferences, practices and actions are the main drivers of global environmental change in the 21st century. It is crucial, therefore, to promote pro-environmental behavior. In order to accomplish this, we need to move beyond rational choice and behavioral decision theories, which do not capture the full range of commitments, assumptions, imaginaries, and belief systems that drive those preferences and actions. Humanities disciplines, such as philosophy, history, religious studies, gender studies, language and literary studies, psychology, and pedagogics do offer deep insights into human motivations, values, and choices. We believe that the expertise of such fields for transforming human preferences, practices and actions is ignored at society’s peril. We propose an agenda that focuses global humanities research on stepping up to the challenges of planetary environmental change. We have established Environmental Humanities Observatories through which to observe, explore and enact the crucial ways humanistic disciplines may help us understand and engage with global ecological problems by providing insight into human action, perceptions, and motivation. We present this Manifesto as an invitation for others to join the “Humanities for the Environment” open global consortium of humanities observatories as we continue to develop a shared research agenda. Full article

Epidemiological studies have identified associations between mortality and changes in concentration of particulate matter. These studies have highlighted the public concerns about health effects of particulate air pollution. Modeling fine particulate matter PM_2.5 exposure risk and monitoring day-to-day changes in PM_2.5 concentration is a critical step for understanding the pollution problem and embarking on the necessary remedy. This research designs, implements and compares two inverse distance weighting (IDW)-based spatiotemporal interpolation methods, in order to assess the trend of daily PM_2.5 concentration for the contiguous United States over the year of 2009, at both the census block group level and county level. Traditionally, when handling spatiotemporal interpolation, researchers tend to treat space and time separately and reduce the spatiotemporal interpolation problems to a sequence of snapshots of spatial interpolations. In this paper, PM_2.5 data interpolation is conducted in the continuous space-time domain by integrating space and time simultaneously, using the so-called extension approach. Time values are calculated with the help of a factor under the assumption that spatial and temporal dimensions are equally important when interpolating a continuous changing phenomenon in the space-time domain. Various IDW-based spatiotemporal interpolation methods with different parameter configurations are evaluated by cross-validation. In addition, this study explores computational issues (computer processing speed) faced during implementation of spatiotemporal interpolation for huge data sets. Parallel programming techniques and an advanced data structure, named k-d tree, are adapted in this paper to address the computational challenges. Significant computational improvement has been achieved. Finally, a web-based spatiotemporal IDW-based interpolation application is designed and implemented where users can visualize and animate spatiotemporal interpolation results. Full article