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Search Results (8)

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Authors = Catherine A. Gordon ORCID = 0000-0002-1509-5220

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30 pages, 1878 KiB  
Review
Schistosomiasis in the Philippines: A Comprehensive Review of Epidemiology and Current Control
by Emmanuel John Tabilin, Darren J. Gray, Mario A. Jiz, Mary Lorraine Mationg, Marianette Inobaya, Eleonor Avenido-Cervantes, Megumi Sato, Marcello Otake Sato, Yasuhito Sako, Yi Mu, Hong You, Matthew Kelly, Pengfei Cai and Catherine A. Gordon
Trop. Med. Infect. Dis. 2025, 10(2), 29; https://doi.org/10.3390/tropicalmed10020029 - 21 Jan 2025
Cited by 3 | Viewed by 13697
Abstract
Schistosomiasis japonica is an infectious parasitic disease caused by infection with the blood fluke Schistosoma japonicum, which is endemic in China, small pockets of Indonesia, and the Philippines. Of the three countries, the prevalence of infection is the highest in the Philippines, [...] Read more.
Schistosomiasis japonica is an infectious parasitic disease caused by infection with the blood fluke Schistosoma japonicum, which is endemic in China, small pockets of Indonesia, and the Philippines. Of the three countries, the prevalence of infection is the highest in the Philippines, despite decades of mass drug administration (MDA). As a zoonosis with 46 potential mammalian definitive hosts and a snail intermediate host, the control and eventual elimination of S. japonicum requires management of these animal hosts in addition to new interventions for the human hosts, including health education and water, sanitation, and hygiene (WASH) infrastructure. In this review we examine the status and epidemiology of S. japonicum in the Philippines with an overview of the current control program there and what needs to be accomplished in the future to control and eliminate this disease in the country. Full article
(This article belongs to the Section Infectious Diseases)
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20 pages, 18745 KiB  
Article
NUSAP1 Binds ILF2 to Modulate R-Loop Accumulation and DNA Damage in Prostate Cancer
by Chun-Lung Chiu, Caiyun G. Li, Erik Verschueren, Ru M. Wen, Dalin Zhang, Catherine A. Gordon, Hongjuan Zhao, Amato J. Giaccia and James D. Brooks
Int. J. Mol. Sci. 2023, 24(7), 6258; https://doi.org/10.3390/ijms24076258 - 26 Mar 2023
Cited by 16 | Viewed by 4170
Abstract
Increased expression of NUSAP1 has been identified as a robust prognostic biomarker in prostate cancer and other malignancies. We have previously shown that NUSAP1 is positively regulated by E2F1 and promotes cancer invasion and metastasis. To further understand the biological function of NUSAP1, [...] Read more.
Increased expression of NUSAP1 has been identified as a robust prognostic biomarker in prostate cancer and other malignancies. We have previously shown that NUSAP1 is positively regulated by E2F1 and promotes cancer invasion and metastasis. To further understand the biological function of NUSAP1, we used affinity purification and mass spectrometry proteomic analysis to identify NUSAP1 interactors. We identified 85 unique proteins in the NUSAP1 interactome, including ILF2, DHX9, and other RNA-binding proteins. Using proteomic approaches, we uncovered a function for NUSAP1 in maintaining R-loops and in DNA damage response through its interaction with ILF2. Co-immunoprecipitation and colocalization using confocal microscopy verified the interactions of NUSAP1 with ILF2 and DHX9, and RNA/DNA hybrids. We showed that the microtubule and charged helical domains of NUSAP1 were necessary for the protein-protein interactions. Depletion of ILF2 alone further increased camptothecin-induced R-loop accumulation and DNA damage, and NUSAP1 depletion abolished this effect. In human prostate adenocarcinoma, NUSAP1 and ILF2 mRNA expression levels are positively correlated, elevated, and associated with poor clinical outcomes. Our study identifies a novel role for NUSAP1 in regulating R-loop formation and accumulation in response to DNA damage through its interactions with ILF2 and hence provides a potential therapeutic target. Full article
(This article belongs to the Section Molecular Oncology)
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13 pages, 1337 KiB  
Article
Spatial Analysis of Schistosomiasis in Hunan and Jiangxi Provinces in the People’s Republic of China
by Kefyalew Addis Alene, Catherine A. Gordon, Archie C. A. Clements, Gail M. Williams, Darren J. Gray, Xiao-Nong Zhou, Yuesheng Li, Jürg Utzinger, Johanna Kurscheid, Simon Forsyth, Jie Zhou, Zhaojun Li, Guangpin Li, Dandan Lin, Zhihong Lou, Shengming Li, Jun Ge, Jing Xu, Xinling Yu, Fei Hu, Shuying Xie and Donald P. McManusadd Show full author list remove Hide full author list
Diseases 2022, 10(4), 93; https://doi.org/10.3390/diseases10040093 - 19 Oct 2022
Cited by 9 | Viewed by 2917
Abstract
Understanding the spatial distribution of schistosome infection is critical for tailoring preventive measures to control and eliminate schistosomiasis. This study used spatial analysis to determine risk factors that may impact Schistosoma japonicum infection and predict risk in Hunan and Jiangxi Provinces in the [...] Read more.
Understanding the spatial distribution of schistosome infection is critical for tailoring preventive measures to control and eliminate schistosomiasis. This study used spatial analysis to determine risk factors that may impact Schistosoma japonicum infection and predict risk in Hunan and Jiangxi Provinces in the People’s Republic of China. The study employed survey data collected in Hunan and Jiangxi in 2016. Independent variable data were obtained from publicly available sources. Bayesian-based geostatistics was used to build models with covariate fixed effects and spatial random effects to identify factors associated with the spatial distribution of infection. Prevalence of schistosomiasis was higher in Hunan (12.8%) than Jiangxi (2.6%). Spatial distribution of schistosomiasis varied at pixel level (0.1 × 0.1 km), and was significantly associated with distance to nearest waterbody (km, β = −1.158; 95% credible interval [CrI]: −2.104, −0.116) in Hunan and temperature (°C, β = −4.359; 95% CrI: −9.641, −0.055) in Jiangxi. The spatial distribution of schistosomiasis in Hunan and Jiangxi varied substantially and was significantly associated with distance to nearest waterbody. Prevalence of schistosomiasis decreased with increasing distance to nearest waterbody in Hunan, indicating that schistosomiasis control should target individuals in close proximity to open water sources as they are at highest risk of infection. Full article
(This article belongs to the Special Issue In Honour of Marcel Tanner, Parasitologist Extraordinaire)
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40 pages, 1375 KiB  
Review
Schistosomiasis with a Focus on Africa
by Oyime Poise Aula, Donald P. McManus, Malcolm K. Jones and Catherine A. Gordon
Trop. Med. Infect. Dis. 2021, 6(3), 109; https://doi.org/10.3390/tropicalmed6030109 - 22 Jun 2021
Cited by 124 | Viewed by 27893
Abstract
Schistosomiasis is a common neglected tropical disease of impoverished people and livestock in many developing countries in tropical Africa, the Middle East, Asia, and Latin America. Substantial progress has been made in controlling schistosomiasis in some African countries, but the disease still prevails [...] Read more.
Schistosomiasis is a common neglected tropical disease of impoverished people and livestock in many developing countries in tropical Africa, the Middle East, Asia, and Latin America. Substantial progress has been made in controlling schistosomiasis in some African countries, but the disease still prevails in most parts of sub-Saharan Africa with an estimated 800 million people at risk of infection. Current control strategies rely primarily on treatment with praziquantel, as no vaccine is available; however, treatment alone does not prevent reinfection. There has been emphasis on the use of integrated approaches in the control and elimination of the disease in recent years with the development of health infrastructure and health education. However, there is a need to evaluate the present status of African schistosomiasis, primarily caused by Schistosoma mansoni and S. haematobium, and the factors affecting the disease as the basis for developing more effective control and elimination strategies in the future. This review provides an historical perspective of schistosomiasis in Africa and discusses the current status of control efforts in those countries where the disease is endemic. Full article
(This article belongs to the Collection Infection Prevention and Control: Practical and Educational Advances)
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29 pages, 5256 KiB  
Review
Asian Schistosomiasis: Current Status and Prospects for Control Leading to Elimination
by Catherine A. Gordon, Johanna Kurscheid, Gail M. Williams, Archie C. A. Clements, Yuesheng Li, Xiao-Nong Zhou, Jürg Utzinger, Donald P. McManus and Darren J. Gray
Trop. Med. Infect. Dis. 2019, 4(1), 40; https://doi.org/10.3390/tropicalmed4010040 - 26 Feb 2019
Cited by 110 | Viewed by 20144
Abstract
Schistosomiasis is an infectious disease caused by helminth parasites of the genus Schistosoma. Worldwide, an estimated 250 million people are infected with these parasites with the majority of cases occurring in sub-Saharan Africa. Within Asia, three species of Schistosoma cause disease. Schistosoma japonicum [...] Read more.
Schistosomiasis is an infectious disease caused by helminth parasites of the genus Schistosoma. Worldwide, an estimated 250 million people are infected with these parasites with the majority of cases occurring in sub-Saharan Africa. Within Asia, three species of Schistosoma cause disease. Schistosoma japonicum is the most prevalent, followed by S. mekongi and S. malayensis. All three species are zoonotic, which causes concern for their control, as successful elimination not only requires management of the human definitive host, but also the animal reservoir hosts. With regard to Asian schistosomiasis, most of the published research has focused on S. japonicum with comparatively little attention paid to S. mekongi and even less focus on S. malayensis. In this review, we examine the three Asian schistosomes and their current status in their endemic countries: Cambodia, Lao People’s Democratic Republic, Myanmar, and Thailand (S. mekongi); Malaysia (S. malayensis); and Indonesia, People’s Republic of China, and the Philippines (S. japonicum). Prospects for control that could potentially lead to elimination are highlighted as these can inform researchers and disease control managers in other schistosomiasis-endemic areas, particularly in Africa and the Americas. Full article
(This article belongs to the Special Issue Prospects for Schistosomiasis Elimination)
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20 pages, 619 KiB  
Review
DNA Diagnostics for Schistosomiasis Control
by Kosala G. Weerakoon, Catherine A. Gordon and Donald P. McManus
Trop. Med. Infect. Dis. 2018, 3(3), 81; https://doi.org/10.3390/tropicalmed3030081 - 1 Aug 2018
Cited by 71 | Viewed by 12052
Abstract
Despite extensive efforts over the last few decades, the global disease burden of schistosomiasis still remains unacceptably high. This could partly be attributed to the lack of accurate diagnostic tools for detecting human and animal schistosome infections in endemic areas. In low transmission [...] Read more.
Despite extensive efforts over the last few decades, the global disease burden of schistosomiasis still remains unacceptably high. This could partly be attributed to the lack of accurate diagnostic tools for detecting human and animal schistosome infections in endemic areas. In low transmission and low prevalence areas where schistosomiasis elimination is targeted, case detection requires a test that is highly sensitive. Diagnostic tests with low sensitivity will miss individuals with low infection intensity and these will continue to contribute to transmission, thereby interfering with the efficacy of the control measures operating. Of the many diagnostic approaches undertaken to date, the detection of schistosome DNA using DNA amplification techniques including polymerase chain reaction (PCR) provide valuable adjuncts to more conventional microscopic and serological methods, due their accuracy, high sensitivity, and the capacity to detect early pre-patent infections. Furthermore, DNA-based methods represent important screening tools, particularly in those endemic areas with ongoing control where infection prevalence and intensity have been reduced to very low levels. Here we review the role of DNA diagnostics in the path towards the control and elimination of schistosomiasis. Full article
(This article belongs to the Special Issue Prospects for Schistosomiasis Elimination)
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25 pages, 923 KiB  
Review
The History of Bancroftian Lymphatic Filariasis in Australasia and Oceania: Is There a Threat of Re-Occurrence in Mainland Australia?
by Catherine A. Gordon, Malcolm K. Jones and Donald P. McManus
Trop. Med. Infect. Dis. 2018, 3(2), 58; https://doi.org/10.3390/tropicalmed3020058 - 4 Jun 2018
Cited by 30 | Viewed by 9869
Abstract
Lymphatic filariasis (LF) infects an estimated 120 million people worldwide, with a further 856 million considered at risk of infection and requiring preventative chemotherapy. The majority of LF infections are caused by Wuchereria bancrofti, named in honour of the Australian physician Joseph [...] Read more.
Lymphatic filariasis (LF) infects an estimated 120 million people worldwide, with a further 856 million considered at risk of infection and requiring preventative chemotherapy. The majority of LF infections are caused by Wuchereria bancrofti, named in honour of the Australian physician Joseph Bancroft, with the remainder due to Brugia malayi and B. timori. Infection with LF through the bite of an infected mosquito, can lead to the development of the condition known as elephantiasis, where swelling due to oedema leads to loss of function in the affected area and thickening of the skin, ‘like an elephant’. LF has previously been endemic in Australia, although currently, no autochthonous cases occur there. Human immigration to Australia from LF-endemic countries, including those close to Australia, and the presence of susceptible mosquitoes that can act as suitable vectors, heighten the possibility of the reintroduction of LF into this country. In this review, we examine the history of LF in Australia and Oceania and weigh up the potential risk of its re-occurrence on mainland Australia. Full article
(This article belongs to the Special Issue Control of Communicable Diseases in Human and in Animal Populations: 70th Anniversary Year of the Birth of Professor Rick Speare (2 August 1947 – 5 June 2016))
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32 pages, 1943 KiB  
Review
Soil-Transmitted Helminths in Tropical Australia and Asia
by Catherine A. Gordon, Johanna Kurscheid, Malcolm K. Jones, Darren J. Gray and Donald P. McManus
Trop. Med. Infect. Dis. 2017, 2(4), 56; https://doi.org/10.3390/tropicalmed2040056 - 23 Oct 2017
Cited by 47 | Viewed by 17712
Abstract
Soil-transmitted helminths (STH) infect 2 billion people worldwide including significant numbers in South-East Asia (SEA). In Australia, STH are of less concern; however, indigenous communities are endemic for STH, including Strongyloides stercoralis, as well as for serious clinical infections due to other [...] Read more.
Soil-transmitted helminths (STH) infect 2 billion people worldwide including significant numbers in South-East Asia (SEA). In Australia, STH are of less concern; however, indigenous communities are endemic for STH, including Strongyloides stercoralis, as well as for serious clinical infections due to other helminths such as Toxocara spp. The zoonotic hookworm Ancylostoma ceylanicum is also present in Australia and SEA, and may contribute to human infections particularly among pet owners. High human immigration rates to Australia from SEA, which is highly endemic for STH Strongyloides and Toxocara, has resulted in a high prevalence of these helminthic infections in immigrant communities, particularly since such individuals are not screened for worm infections upon entry. In this review, we consider the current state of STH infections in Australia and SEA. Full article
(This article belongs to the Special Issue Neglected and Emerging Tropical Diseases in South and Southeast Asia and Northern Australia)
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