Search Results (3)

Background: Vaccination has played a crucial role in mitigating the spread of COVID-19 and reducing its severe outcomes. While over 90% of Bangladesh’s population has received at least one COVID-19 vaccine dose, the comparative effectiveness of homologous versus heterologous booster strategies, along with the complex interplay of factors within the population, remains understudied. This study aimed to compare antibody responses between these booster approaches. Methods: This cross-sectional study enrolled 723 adults in urban Dhaka who had received COVID-19 booster doses within the last six months. Participants were grouped based on homologous or heterologous booster vaccination. Data were collected through structured household surveys, and 2 mL blood samples were collected for measuring antibody titers. Results: Heterologous booster recipients showed higher median antibody titers (8597.0 U/mL, IQR 5053.0–15,482.3) compared to homologous recipients (6958.0 U/mL, IQR 3974.0–12,728.5). In the adjusted analysis, the type of booster dose had no significant impact on antibody levels. However, the duration since the last booster dose was significantly associated with antibody levels, where each additional month since receiving the booster corresponded to approximately a 15–16% reduction in antibody levels (Adj. coeff: 0.85, 95% CI: 0.81, 0.88; p < 0.001). Participants over 40 years demonstrated higher antibody levels than younger individuals (Adj. coeff: 1.23, 95% CI: 1.07, 1.43; p = 0.005). Sex, BMI, and prior COVID-19 infection showed no significant associations with antibody levels after adjustment. Conclusion: The results underscore the complexity of immune responses across different demographic groups and suggest potential benefits of ongoing heterologous booster strategies in sustaining immunity. Full article

Microplastics’ dangers and the absence of effective regulation technologies have risen to prominence as a worldwide issue in recent years. South Asian countries, such as Bangladesh, are among the most threatened nations to face the drastic consequence of releasing microplastics into the aquatic environment. The research on managing and degrading microplastics is ongoing, however, sustainable techniques have not yet been found. To create a green and efficient microplastic management plan, we have compiled all the information on the existing removal and degradation techniques for microplastics and provided an overview of all the noteworthy methods that can be implemented in Bangladesh. In the portrayed biotic and abiotic techniques, coagulation and photocatalysis were found to be most efficient in removing microplastics (as high as 99%) in different studies. The concept of microplastic is new to the researchers of Bangladesh, therefore, the characteristics, occurrence, fate, and threats are briefly discussed in this paper. Sampling, extraction, and identification methods of microplastic in freshwater and sediment samples are also thoroughly specified. The sources of microplastic pollution in Bangladesh and possible strategies that can be implemented to minimize additional microplastic discharge into aquatic environments are discussed. Although Bangladesh was the very first country to ban polythene, the failure of the implementation of rules and regulations and a lack of management strategy made Bangladesh the 10th worst country in managing plastic waste. This work is a wake-up call for other researchers to conduct an in-depth investigation to improve microplastic degrading technologies and develop a sustainable strategy to end microplastic pollution in Bangladesh. Full article

Total hip replacement (THR) is a common orthopedic surgery technique that helps thousands of individuals to live normal lives each year. A hip replacement replaces the shattered cartilage and bone with an implant. Most hip implants fail after 10–15 years. The material selection for the total hip implant systems is a major research field since it affects the mechanical and clinical performance of it. Stress shielding due to excessive contact stress, implant dislocation due to a large deformation, aseptic implant loosening due to the particle propagation of wear debris, decreased bone remodeling density due to the stress shielding, and adverse tissue responses due to material wear debris all contribute to the failure of hip implants. Recent research shows that pre-clinical computational finite element analysis (FEA) can be used to estimate four mechanical performance parameters of hip implants which are connected with distinct biomaterials: von Mises stress and deformation, micromotion, wear estimates, and implant fatigue. In vitro, in vivo, and clinical stages are utilized to determine the hip implant biocompatibility and the unfavorable local tissue reactions to different biomaterials during the implementation phase. This research summarizes and analyses the performance of the different biomaterials that are employed in total hip implant systems in the pre-clinical stage using FEA, as well as their performances in in vitro, in vivo, and in clinical studies, which will help researchers in gaining a better understanding of the prospects and challenges in this field. Full article