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Volume 26
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10.3390/molecules26020335
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Article

Novel Amides Derivative with Antimicrobial Activity of Piper betle var. nigra Leaves from Indonesia

by
Fajar Prasetya
1,
Supriatno Salam
2,
Agung Rahmadani
1,2,3,
Kansy Haikal
2,
Lizma Febrina
1,
Hady Anshory
4,
Muhammad Arifuddin
1,
Vita Olivia Siregar
1,
Angga Cipta Narsa
1,
Herman Herman
1,
Islamudin Ahmad
1,
Niken Indriyanti
1,
Arsyik Ibrahim
1,
Rolan Rusli
1,
Laode Rijai
1 and
Hadi Kuncoro
1,*
1
Faculty of Pharmacy, Universitas Mulawarman, Samarinda 75123, Kalimantan Timur, Indonesia
2
Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor, Sumedang 45363, Indonesia
3
Departement of Chemistry Education, Faculty of Teaching and Education, Mulawarman University, Samarinda 75123, Kalimantan Timur, Indonesia
4
Departement of Pharmacy, Faculty of Mathematics and Natural Sciences, Islamic University of Indonesia, Jogjakarta 55584, Indonesia
*
Author to whom correspondence should be addressed.
Molecules 2021, 26(2), 335; https://doi.org/10.3390/molecules26020335
Submission received: 11 December 2020 / Revised: 5 January 2021 / Accepted: 7 January 2021 / Published: 11 January 2021
(This article belongs to the Section Natural Products Chemistry)
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Abstract

Piper betle var. nigra is a tropical plant closely related to the common piper. P. betle has also been dubbed a promising source of natural antioxidants in herbal health products, antibacterial, antifungal, antimalarial, cytotoxic activity against the cancer cell lines K562 and HL-60, and antileishmanial. The aim of this study to observation Antimicrobial activity and isolation of chemical compound. The antimicrobial activity of P. betle extract was performed by well diffusion method against two oral pathogenic bacteria (Streptococcus mutans and Streptococcus sanguinis) and opportunistic pathogenic yeast (Candida albicans). The inoculum (bacterial and yeast suspension) was prepared from a 24-h culture on NB for bacterial suspension and on TSB for yeast suspension. Extraction and isolation using various method of chromatography. Isolated compounds were characterized by spectroscopic means. Our study showed antimicrobial activity from crude ethanol extract of leaves P. betle L. var. nigra against two oral pathogenic bacteria and opportunistic pathogenic yeast with concentration 0.5% and 1%. The first report of two new amides derivatives, piperenamide A (1) and piperenamide B (2) in P. betle L. var. nigra.
Keywords: Piper betle var. nigra; Streptococcus mutans; Streptococcus sanguinis; Candida albicans; piperenamide A; piperenamide B Piper betle var. nigra; Streptococcus mutans; Streptococcus sanguinis; Candida albicans; piperenamide A; piperenamide B

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MDPI and ACS Style

Prasetya, F.; Salam, S.; Rahmadani, A.; Haikal, K.; Febrina, L.; Anshory, H.; Arifuddin, M.; Siregar, V.O.; Narsa, A.C.; Herman, H.; et al. Novel Amides Derivative with Antimicrobial Activity of Piper betle var. nigra Leaves from Indonesia. Molecules 2021, 26, 335. https://doi.org/10.3390/molecules26020335

AMA Style

Prasetya F, Salam S, Rahmadani A, Haikal K, Febrina L, Anshory H, Arifuddin M, Siregar VO, Narsa AC, Herman H, et al. Novel Amides Derivative with Antimicrobial Activity of Piper betle var. nigra Leaves from Indonesia. Molecules. 2021; 26(2):335. https://doi.org/10.3390/molecules26020335

Chicago/Turabian Style

Prasetya, Fajar, Supriatno Salam, Agung Rahmadani, Kansy Haikal, Lizma Febrina, Hady Anshory, Muhammad Arifuddin, Vita Olivia Siregar, Angga Cipta Narsa, Herman Herman, and et al. 2021. "Novel Amides Derivative with Antimicrobial Activity of Piper betle var. nigra Leaves from Indonesia" Molecules 26, no. 2: 335. https://doi.org/10.3390/molecules26020335

APA Style

Prasetya, F., Salam, S., Rahmadani, A., Haikal, K., Febrina, L., Anshory, H., Arifuddin, M., Siregar, V. O., Narsa, A. C., Herman, H., Ahmad, I., Indriyanti, N., Ibrahim, A., Rusli, R., Rijai, L., & Kuncoro, H. (2021). Novel Amides Derivative with Antimicrobial Activity of Piper betle var. nigra Leaves from Indonesia. Molecules, 26(2), 335. https://doi.org/10.3390/molecules26020335

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