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Volume 21
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Current Issues in Molecular Biology is published by MDPI from Volume 43 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Caister Press.
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Review

Cyclophilin A: A Key Factor in Virus Replication and Potential Target for Anti-Viral Therapy

by
Farman Ullah Dawar
1,2,†,
Jiagang Tu
1,†,
Muhammad Nasir Khan Khattak
3,
Jie Mei
2,* and
Li Lin
1,2,*
1
Department of Aquatic Animal Medicine, College of Fisheries, Huazhong Agricultural University, Wuhan 430070, Hubei, China
2
Key Lab of Freshwater Animal Breeding, Ministry of Agriculture, Huazhong Agricultural University, Wuhan 430070, Hubei, China
3
Department of Zoology, Hazara University Mansehra, Khyber Pakhtoonkhwa 21300, Pakistan
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Curr. Issues Mol. Biol. 2017, 21(1), 1-20; https://doi.org/10.21775/cimb.021.001
Submission received: 3 February 2016 / Revised: 7 March 2016 / Accepted: 10 March 2016 / Published: 2 April 2016
Versions Notes

Abstract

Cyclophilin A (CypA) is a key member of immunophilins that has peptidyl-prolyl cis/trans isomerase (PPIase) activity. Besides acting as a cellular receptor for immunosuppressive drug cyclosporine A (CsA), CypA is involved in various cellular activities. CypA has an important role in viral infection which either facilitates or inhibits their replication. Inhibition of CypA via inhibitors is useful for overcoming several viral infections, indicating that CypA is an attractive target for anti-viral therapy. Collectively, these facts demonstrate the critical roles of CypA in mediating or inhibiting viral infections, suggesting that CypA can be an attractive cellular target for the development of anti-viral therapy.

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MDPI and ACS Style

Dawar, F.U.; Tu, J.; Khattak, M.N.K.; Mei, J.; Lin, L. Cyclophilin A: A Key Factor in Virus Replication and Potential Target for Anti-Viral Therapy. Curr. Issues Mol. Biol. 2017, 21, 1-20. https://doi.org/10.21775/cimb.021.001

AMA Style

Dawar FU, Tu J, Khattak MNK, Mei J, Lin L. Cyclophilin A: A Key Factor in Virus Replication and Potential Target for Anti-Viral Therapy. Current Issues in Molecular Biology. 2017; 21(1):1-20. https://doi.org/10.21775/cimb.021.001

Chicago/Turabian Style

Dawar, Farman Ullah, Jiagang Tu, Muhammad Nasir Khan Khattak, Jie Mei, and Li Lin. 2017. "Cyclophilin A: A Key Factor in Virus Replication and Potential Target for Anti-Viral Therapy" Current Issues in Molecular Biology 21, no. 1: 1-20. https://doi.org/10.21775/cimb.021.001

APA Style

Dawar, F. U., Tu, J., Khattak, M. N. K., Mei, J., & Lin, L. (2017). Cyclophilin A: A Key Factor in Virus Replication and Potential Target for Anti-Viral Therapy. Current Issues in Molecular Biology, 21(1), 1-20. https://doi.org/10.21775/cimb.021.001

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