Next Article in Journal
Mental Health Professionals’ Views on Artificial Intelligence as an Aide for Children Anticipating or Suffering the Loss of a Parent to Cancer: Helpful or Harmful?
Next Article in Special Issue
The Utility of Umbilical Cord Pulse Oximetry—A Translational Study with Four Minutes of Deferred Cord Clamping Using an Asphyxiated Preterm Ovine Model
Previous Article in Journal
Changes in Motor Function in a Child with Cerebral Palsy Following Multiple Botulinum Toxin Injections: A Case Report
Previous Article in Special Issue
The Role of Genetic Testing in Palliative Care Decisions for Critically Ill Newborns
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Children
Volume 12
Issue 6
10.3390/children12060762
children-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Systematic Review

Association Between Hypertensive Disorders of Pregnancy and Patent Ductus Arteriosus in Very Preterm Infants: A Bayesian Model-Averaged Meta-Analysis

by
Moreyba Borges-Luján
1,
Gloria Galán-Henríquez
1,
Rosa I. Rodríguez-Viera
1,
František Bartoš
2,
Gema E. González-Luis
1 and
Eduardo Villamor
3,*
1
Department of Pediatrics, Hospital Universitario Materno-Infantil de Canarias, 35016 Las Palmas de Gran Canaria, Spain
2
Department of Psychology, University of Amsterdam, 1018WS Amsterdam, The Netherlands
3
Division of Neonatology, MosaKids Children’s Hospital, Maastricht University Medical Center (MUMC+), Research Institute for Oncology and Reproduction (GROW), Maastricht University, 6202AZ Maastricht, The Netherlands
*
Author to whom correspondence should be addressed.
Children 2025, 12(6), 762; https://doi.org/10.3390/children12060762
Submission received: 16 May 2025 / Revised: 3 June 2025 / Accepted: 10 June 2025 / Published: 12 June 2025
(This article belongs to the Special Issue Advances in Intensive Care for Critically Ill Neonates: Clinical Diagnosis and Treatment)
Browse Figures
Versions Notes

Abstract

Background/Objectives: Prenatal adverse events may influence the development of complications of prematurity, including patent ductus arteriosus (PDA). We conducted a systematic review and Bayesian model-averaged (BMA) meta-analysis of observational studies exploring the association between hypertensive disorders of pregnancy (HDP) and the risk of PDA in preterm infants. Methods: PubMed/Medline and Embase databases were searched. We used BMA analysis to calculate Bayes factors (BFs). The BF10 is the ratio of the probability of the data under the alternative hypothesis (H1, presence of association) over the probability of the data under the null hypothesis (H0, absence of association). Results: We included 41 studies (58,004 infants). BMA analysis showed moderate evidence in favour of H0 for the association between HDP and any PDA (BF10 = 0.20) as well as for the association between HDP and hemodynamically significant PDA (BF10 = 0.27). Subgroup analyses based on the subtype of HDP showed that the moderate evidence in favour of H0 was only conclusive (i.e., BF10 < 0.33) for the associations of any PDA with preeclampsia (BF10 = 0.30) and hemodynamically significant PDA with preeclampsia (BF10 = 0.17). Conclusions: The currently available evidence suggests a lack of association between HDP and the risk of developing PDA.
Keywords: patent ductus arteriosus; preeclampsia; preterm infant; Bayesian statistics; meta-analysis patent ductus arteriosus; preeclampsia; preterm infant; Bayesian statistics; meta-analysis

Share and Cite

MDPI and ACS Style

Borges-Luján, M.; Galán-Henríquez, G.; Rodríguez-Viera, R.I.; Bartoš, F.; González-Luis, G.E.; Villamor, E. Association Between Hypertensive Disorders of Pregnancy and Patent Ductus Arteriosus in Very Preterm Infants: A Bayesian Model-Averaged Meta-Analysis. Children 2025, 12, 762. https://doi.org/10.3390/children12060762

AMA Style

Borges-Luján M, Galán-Henríquez G, Rodríguez-Viera RI, Bartoš F, González-Luis GE, Villamor E. Association Between Hypertensive Disorders of Pregnancy and Patent Ductus Arteriosus in Very Preterm Infants: A Bayesian Model-Averaged Meta-Analysis. Children. 2025; 12(6):762. https://doi.org/10.3390/children12060762

Chicago/Turabian Style

Borges-Luján, Moreyba, Gloria Galán-Henríquez, Rosa I. Rodríguez-Viera, František Bartoš, Gema E. González-Luis, and Eduardo Villamor. 2025. "Association Between Hypertensive Disorders of Pregnancy and Patent Ductus Arteriosus in Very Preterm Infants: A Bayesian Model-Averaged Meta-Analysis" Children 12, no. 6: 762. https://doi.org/10.3390/children12060762

APA Style

Borges-Luján, M., Galán-Henríquez, G., Rodríguez-Viera, R. I., Bartoš, F., González-Luis, G. E., & Villamor, E. (2025). Association Between Hypertensive Disorders of Pregnancy and Patent Ductus Arteriosus in Very Preterm Infants: A Bayesian Model-Averaged Meta-Analysis. Children, 12(6), 762. https://doi.org/10.3390/children12060762

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop