State-of-the-Art of Kidney Transplantation

A special issue of Transplantology (ISSN 2673-3943). This special issue belongs to the section "Solid Organ Transplantation".

Deadline for manuscript submissions: closed (15 March 2023) | Viewed by 2294

Special Issue Editor


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Guest Editor
Department of Urology, Division of Transplant Surgery, Miami Transplant Institute-Jackson Memorial Hospital, Miami, FL, USA
Interests: kidney and pancreas transplantation; living donor kidney transplantation; transplant immunology; xeno-transplantation; new surgical techniques in kidney transplantation
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Special Issue Information

Dear Colleagues,

An overview of clinical Kidney transplantation during the last decade includes increasing attempts to reduce the short- and long-term side effects of immunosuppression drugs, the reduction or avoidance of corticosteroids, and the reduction of acute rejection and chronic allograft injury. Another important key area in kidney transplantation is the elusive goal of inducing a permanent state of tolerance to the allograft and making it free of long-term immunosuppressive therapy. A few transplant centers are getting closer to inducing tolerance in humans and it could be a reality in the near future. We have also seen an increase in the number of donations after cardiac deaths, robotic kidney transplantation, and living donor kidney transplants with great clinical and surgical outcomes. Regenerative medicine, organ bioengineering, organogenesis, and xenotransplantation are making their way into Kidney transplantation, and they are making important contributions to the field of transplantation.

Transplantology wants to release a Special Issue about “State-of the-Art of Kidney Transplantation.” These manuscripts should address novel clinical trial immunosuppression protocols, surgical innovations in the field of Kidney transplantation, immune mechanisms of allograft rejection, any novel strategy that optimizes long-term allograft and patient survival, intestinal transplantation, regenerative medicine, tolerance, living kidney donation and transplantation. We also want to include comprehensive reviews, basic research and any interesting topic that will enrich the field of kidney transplantation. 

Prof. Dr. Gaetano Ciancio
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Transplantology is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Solid organ transplantation
  • Tejection
  • Immunosuppression
  • Tolerance
  • Regenerative medicine

Published Papers (1 paper)

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5 pages, 186 KiB  
Case Report
Successful Utilization of Kidney Allografts with Diffuse Glomerular Fibrin Thrombi on the Preimplantation Biopsy after Circulatory Death: A Case Series
by Sushma Bhusal, Hailey Hardgrave, Aparna Sharma, Lyle Burdine, Raj Patel, Gary Barone, Neriman Gokden and Emmanouil Giorgakis
Transplantology 2023, 4(1), 12-16; https://doi.org/10.3390/transplantology4010002 - 12 Jan 2023
Viewed by 1596
Abstract
Background: Kidney allografts with the presence of diffuse glomerular fibrin thrombi are typically rejected by most centers due to concern for poor allograft outcomes in the recipients. The aim of this study was to report our single center experience in the use of [...] Read more.
Background: Kidney allografts with the presence of diffuse glomerular fibrin thrombi are typically rejected by most centers due to concern for poor allograft outcomes in the recipients. The aim of this study was to report our single center experience in the use of such deceased donor allografts. Methods: Retrospective single-center cohort study of kidney transplant recipients who received deceased donor allografts with moderate-to-severe diffuse glomerular fibrin microthrombi on the pre-implantation biopsy. Results: Three adult recipients received deceased donor kidney transplantation from donation after circulatory death donors. One patient was pre-emptive to dialysis at the time of transplant. The donors had moderate-to-severe diffuse glomerular fibrin thrombi on preimplantation biopsies with no evidence of cortical necrosis. Mean follow-up period was 196 days. None of the recipients developed delayed allograft function. The mean 3-month and 6-month creatinine were 1.6 and 1.5 mg/dL, respectively, with corresponding mean eGFRs (estimated glomerular filtration rates) of 45.7 and 47.3 mL/min/1.73m2. Conclusions: After excluding significant cortical necrosis by experienced transplant renal pathologist, otherwise transplantable kidney allografts with diffuse fibrin thrombi may be successfully transplanted in renal transplant recipients with good renal outcomes. Full article
(This article belongs to the Special Issue State-of-the-Art of Kidney Transplantation)
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