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Journals
Transplantology
Special Issues
New Horizons in Transplantation Research: A Review Series
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New Horizons in Transplantation Research: A Review Series

A special issue of Transplantology (ISSN 2673-3943).

Deadline for manuscript submissions: 15 March 2026 | Viewed by 1098

Special Issue Editors

Prof. Dr. Maurizio Salvadori

E-Mail Website
Guest Editor
Department of Transplantation—Renal Unit, Careggi University Hospital, 50139 Florence, Italy
Interests: immunology; renal transplantation; epidemiology; coronavirus infection; organ transplantation
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Gaetano Ciancio

E-Mail Website
Guest Editor
Department of Urology, Division of Transplant Surgery, Miami Transplant Institute—Jackson Memorial Hospital, Miami, FL, USA
Interests: kidney and pancreas transplantation; living donor kidney transplantation; transplant immunology; xeno-transplantation; new surgical techniques in kidney transplantation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Organ and cell transplantation have revolutionized the treatment of end-stage organ failure and various hematological disorders. As the field continues to evolve, significant advances in immunology, regenerative medicine, precision diagnostics, and immunosuppressive strategies are opening new frontiers and transforming clinical outcomes.

This Special Issue series, New Horizons in Transplantation Research: A Review Series, brings together leading experts to provide comprehensive and insightful overviews of the latest developments, persistent challenges, and emerging opportunities in transplantation science. From innovative approaches to graft tolerance and immune monitoring, to breakthroughs in xenotransplantation, organ preservation, and bioengineering, each review is designed to serve as a valuable resource for researchers, clinicians, and students alike.

By highlighting both the progress made and the pressing questions that remain, this series aims to inspire further innovation and interdisciplinary collaboration, ultimately advancing the future of transplantation medicine.

Prof. Dr. Maurizio Salvadori
Prof. Dr. Gaetano Ciancio
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Transplantology is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • organ transplantation
  • cell transplantation
  • graft tolerance
  • immune monitoring
  • xenotransplantation
  • organ preservation
  • regenerative medicine
  • immunosuppressive strategies
  • bioengineering
  • precision diagnostics

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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Review

34 pages, 1585 KB  
Review
Liver Transplantation in the Era of Metabolic Dysfunction–Associated Fatty Liver Disease: Challenges, Ethical Dilemmas, and Future Directions
by Said A. Al-Busafi and Mohammed Eslam
Transplantology 2025, 6(4), 35; https://doi.org/10.3390/transplantology6040035 - 21 Nov 2025
Viewed by 796
Abstract
Metabolic dysfunction–associated fatty liver disease (MAFLD) is now the leading indication for liver transplantation (LT), reshaping the landscape of transplant hepatology. Its close association with obesity, type 2 diabetes, cardiovascular disease, and extrahepatic malignancies poses unique challenges throughout the transplant continuum. This narrative [...] Read more.
Metabolic dysfunction–associated fatty liver disease (MAFLD) is now the leading indication for liver transplantation (LT), reshaping the landscape of transplant hepatology. Its close association with obesity, type 2 diabetes, cardiovascular disease, and extrahepatic malignancies poses unique challenges throughout the transplant continuum. This narrative review synthesizes current evidence across the pre-, peri-, and post-transplant spectrum, with a focus on practical implications for clinical management. We explore pre-transplant evaluation, focusing on how metabolic comorbidities, frailty, and organ allocation disparities intersect with emerging interventions such as GLP-1 receptor agonists, bariatric surgery, and structured weight loss programs. The increase in pediatric MAFLD, especially its early-onset aggressive form, indicates an evolving and concerning future burden on transplant programs. In the peri-operative and post-transplant periods, we address MAFLD recurrence, cardiometabolic complications, and the rising incidence of new cancers, particularly in relation to calcineurin inhibitor (CNI) exposure. Customized immunosuppression strategies, using mTOR inhibitors and mycophenolate mofetil, are discussed for their role in balancing graft protection with reducing cancer risk. We also review the application of machine perfusion technologies to optimize and expand the pool of steatotic donor livers. Future directions include the development of non-invasive diagnostic biomarkers, precision immunosuppression, and genomics-based risk stratification. Collectively, these insights emphasize the urgent need for multidisciplinary, patient-specific approaches and prospective, multicenter studies to optimize outcomes and equity in the era of MAFLD-driven liver transplantation. Full article
(This article belongs to the Special Issue New Horizons in Transplantation Research: A Review Series)
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