Advances in Organofluorine Chemistry—From Methodology to Applications

Dear Colleagues,

An enormous amount of progress has been witnessed in fluorine chemistry in the last two decades, and it has become a mainstream research topic in organic synthesis. The interest of the scientific community towards fluorine hinges on its ability to endow organic scaffolds with unexpected properties. The most striking example is acetic acid vs. fluoroacetic acid, the former being the main component of the everyday-used vinegar and the latter—one of the few naturally occurring organofluorides—is a potent disruptor of the Krebs cycle.

Despite this, man-made organofluorides have emerged as highly valuable drug candidates, and 20% of currently approved drugs contain fluoride atoms or fluorinated groups. Furthermore, fluorine-containing compounds are important diagnostics in PET imaging, contrast agents for MRI, and emerging reactive warheads for chemical biology.

The abovementioned applications were boosted by outstanding advances in organic synthesis that aimed at the insertion of fluorine and fluorinated moieties onto organic scaffolds.

This Special Issue of Organics aims to include advances in fluorine chemistry and radiochemistry, including methodology developments in the late-stage insertion of fluorine and fluorinated groups with different levels of fluorination. We welcome all articles that focus on such chemical transformations, such as novel synthetic methods, modifications, and expansions of existing methods; physicochemical or mechanistic investigations; or relevant reports of unsuccessful endeavours. Furthermore, it extends towards synthetic developments that target specific tools applicable to PET, MRI, and chemical biology. Review articles by experts in the field are also welcome.

Dr. Ermal Ismalaj
Dr. Joachim Demaerel
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Organics is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• fluorine chemistry
• fluorinated groups
• imaging
• fluoroalkylation
• 18F-labeling
• main group chemistry