The PI3K Pathway in Human Disease from the Bench to the Clinic: There and Back Again
A special issue of Kinases and Phosphatases (ISSN 2813-3757).
Deadline for manuscript submissions: 28 February 2025 | Viewed by 2126
Special Issue Editors
Interests: cellular signaling; lipid-activated protein kinases; identification of isoform-specific substrates of the AKT protein kinase; modulation of glycolytic vs. oxidative cellular phenotypes by signaling pathways in acute leukemia models; definition of the phosphorylome of primary blast cells from leukemia patients, and its modulation by the PI3K pathway; kinase-inhibitor therapy in hematological malignancies
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Signaling of the phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) represents a key intracellular pathway, regarded as a master regulator of cell processes and cellular functions (such as cell growth, proliferation, differentiation, motility, survival, and intracellular trafficking). However, it is also recognized as one of the most frequently altered pathways in human cancer, comprising the oncogene PIK3CA and the tumor suppressor gene PTEN, and dysfunction of the PI3K/AKT/mTOR pathway is implicated in several severe conditions, including cancer, cardiovascular disease, type 2 diabetes, autoimmune disorders, and neurological conditions. Despite its attractivity as a therapeutic target for the treatment of cancer in primis, as well as an accruing body of scientific knowledge and massive efforts devoted to the development of drug targeting PI3K signaling, only few molecules have translated into the clinic, and more are currently employed in clinical trial evaluation.
On these bases, this Special Issue aims to provide a platform for bench and clinic research on the different aspects and the numerous players of the PI3K pathway, with a special focus on resistance mechanisms in relation to PI3K/AKT/mTOR inhibition. We warmly welcome your submissions of original papers and reviews based on results from recent viewpoints.
This Special Issue is led by Dr. Sandra Marmiroli and Dr. Alessandro Poli, assisted by our Guest Editors' assistant editor Dr. Francesca Paganelli <[email protected]> (Department of Biomedical and Neuromotor Sciences, Alma Mater Studiorum, University of Bologna, 40136 Bologna, Italy).
Prof. Dr. Sandra Marmiroli
Dr. Alessandro Poli
Guest Editors
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Keywords
- PI3K pathway
- phosphatidylinositol-3-kinase
- AKT
- mTOR
- inhibition
- cancer
- cardiovascular disease
- type 2 diabetes
- autoimmune disorders
- human disease
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