Pathology and Molecular Biology of Inflammatory Diseases
A special issue of Journal of Molecular Pathology (ISSN 2673-5261).
Deadline for manuscript submissions: 31 October 2025 | Viewed by 58
Special Issue Editor
Special Issue Information
Dear Colleagues,
Emerging evidence increasingly positions the gut as a central modulator of systemic inflammation, with intestinal dysfunction contributing to disease processes in distant organs. This Special Issue of the Journal of Molecular Pathology brings together original research and reviews that examine the molecular and histopathological basis of inflammatory diseases, with a particular focus on gut–organ communication. The contributions explore how disruptions in the intestinal barrier, alterations in the gut microbiota, and local immune responses influence systemic pathology in organs such as the liver, lung, skin, and brain.
Highlighted topics include mechanisms of microbial translocation, cytokine signaling, reactive oxygen species, and metabolic mediators that bridge intestinal and extraintestinal inflammation. The Special Issue also features studies leveraging advanced techniques—such as single-cell transcriptomics, spatial profiling, and metabolomics—to dissect gut-derived influences on systemic immune regulation.
By integrating molecular biology with disease pathology across tissues, this collection offers new insights into the gut’s role in shaping inflammatory disease trajectories and therapeutic response. These studies underscore the need to consider mucosal immunity and barrier function in understanding and treating systemic inflammatory conditions.
Dr. Ian Cartwright
Guest Editor
Manuscript Submission Information
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Keywords
- gut–organ axis
- mucosal immunology
- intestinal barrier dysfunction
- microbiome-host interactions
- systemic inflammation
- cytokine signaling
- oxidative stress
- inflammatory biomarkers
- host-microbe crosstalk
- extraintestinal manifestations
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