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Journal of Ageing and Longevity

Journal of Ageing and Longevity is an international, peer-reviewed, open access journal on all aspects of ageing and longevity published quarterly online by MDPI.
The Italian Longevity League (ILL) is affiliated with the Journal of Ageing and Longevity and its members receive discounts on the article processing charges.

All Articles (171)

Sex steroid hormones play a pivotal role in maintaining systemic homeostasis throughout life. Their age-related decline is closely associated with the onset of frailty, including sarcopenia and dementia. Here, this article provides a narrative review of the existing literature about the multifaceted roles of sex steroid hormones, particularly estrogens and androgens, in aging and age-related diseases. Sex steroid action is mediated by nuclear receptors such as estrogen receptor alpha (ERα) and androgen receptor (AR). Transcriptional activation through these receptors is orchestrated by epigenetic mechanisms, including histone modifications and chromatin remodeling. Beyond their reproductive functions, sex hormones also influence systemic physiology, metabolism, immune responses, and neuroplasticity. Clinical studies on hormone-deprivation therapies for prostate and breast cancers, as well as animal models, have revealed the key contributions of AR and ER activity to muscle integrity, bone density, and cognitive function. The sexual dimorphism in cognitive decline, especially in postmenopausal women, suggests the therapeutic potential of hormone supplementation and receptor-targeted strategies. Thus, AR- and ER-associated genes are considered promising targets for preventing frailty, sarcopenia, osteoporosis, and dementia. This review summarizes the current knowledge on sex hormone signaling in aging, with an emphasis on translational implications and future research directions.

3 February 2026

Molecular mechanisms for sex hormone receptor transcriptional actions. (A) Nuclear receptors dimerize and bind to gene promoters or enhancers at hormone response elements (HREs). Co-activators and Co-repressors bind to the activation function-2 (AF-2) domain and recruit histone modification enzymes including histone deacetylases, acetyltransferases or protein lysine methyltransferases. Co-activators binding to the nuclear receptor complex promote with transcriptional activation, leading to the target genes to be expressed. T: testosterone, E2: estradiol. Ac: acetylation, CH3: methylation. (B) Transcription factors and transcriptional co-regulators form condensates through liquid–liquid phase separation (LLPS) by multivalent interactions mediated via intrinsically disordered regions (IDRs), thereby promoting the formation of super-enhancers. (C) Tissue-specific transcription factors called ‘pioneer factors’ such as forkhead box protein A1 (FOXA1) are important for enhancer activation and nuclear receptor recruitment.

Metabolic syndrome (MetS) is common in later life and shaped by modifiable lifestyle and clinical factors, yet data specific to rural older adults are limited. This cross-sectional study analyzed rural Koreans aged ≥65 years (unweighted n = 467) from the 2023 Korea National Health and Nutrition Examination Survey, incorporating the complex survey design (strata, clusters, and weights). MetS was defined using National Cholesterol Education Program Adult Treatment Panel III criteria with Asian-specific waist cutoffs (≥3 of 5 components). Sociodemographic, behavioral, and clinical characteristics were compared by MetS status using design-based tests, and complex-sample logistic regression estimated adjusted odds ratios (aORs) with 95% confidence intervals (CIs). The survey-weighted prevalence of MetS was 42.8%. Compared with those without MetS, participants with MetS had higher body mass index (BMI) and waist circumference, more hypertension and diabetes, higher triglycerides, and lower high-density lipoprotein cholesterol; low-density lipoprotein cholesterol did not differ meaningfully. In multivariable models, BMI ≥25 kg/m2 (aOR 9.08; 95% CI 6.01–13.71, p ≤ 0.001), hemoglobin A1c ≥ 7.0% (aOR 4.42; 95% CI 1.75–11.16, p = 0.003), and vitamin D deficiency <20 ng/mL (aOR 2.32; 95% CI 1.23–4.35, p = 0.012) were independently associated with higher odds of MetS, whereas meeting the World Health Organization physical activity guideline was inversely associated (aOR 0.50; 95% CI 0.26–0.96, p = 0.039). These findings highlight adiposity, suboptimal glycemic control, and vitamin D deficiency as key, potentially modifiable correlates of MetS in rural older adults and support promotion of guideline-level physical activity as part of integrated cardiometabolic risk management in rural settings.

10 February 2026

The main aim of this study is to evaluate the effect of a health promotion-based psychoeducational intervention on Health Literacy (HL) and Digital Health Literacy (DHL) levels in older people. This one-group pre–post design study includes a sample of community-dwelling older people, at risk of social isolation, sedentary lifestyles, or physical deterioration. A multidimensional assessment protocol, with specific measures of HL and DHL, was applied before and after the intervention. The psychoeducational intervention includes 20 sessions, conducted by a multidisciplinary team and focused on four core areas (Health Promotion, Interpersonal Relationships and Citizens’ Rights, Health Literacy, and Digital Health Literacy). Non-parametric statistics tests (Wilcoxon signed-rank test) were used, since data did not follow a normal distribution. Seventy-nine older persons participated, with a mean age of 71.7 (SD = 4.6), mostly female (66%) and with basic education (91%). There was a statistically significant increase in the mean total HL score (Z = −3.132; p = 0.002; effect size r = 0.76) and DHL score (Z = −4.735; p < 0.001; effect size r = 0.61) after the intervention, reflecting an improvement in HL and DHL levels. This study showed that this intervention was effective in improving the HL and DHL levels of older adults. These results are particularly noteworthy, considering that HL and DHL are modifiable factors that influence self-management, as well as health outcomes in older adults.

5 February 2026

This study examined how resilience-based interventions enable rural older women living with HIV in Zimbabwe to confront stigma and sustain their quality of life. Guided by the 4S framework of resilience resources planning (social support, coping strategies, sagacity, and solution-seeking), the research explored how women apply these dimensions to navigate challenging life events. A purposive sample of 17 women (those not living with a spouse or in a socially sanctioned relationship), aged 40–65, all on antiretroviral therapy and drawn from rural Matabeleland South Province, participated through in-depth interviews. Using Interpretive Phenomenological Analysis, four themes emerged: (1) Social Support and Social Networks as Foundations of Resilience, (2) Self-Efficacy and Coping Strategies in Managing Emotional Distress, (3) Spirituality and Sagacity as Sources of Strength and Meaning, and (4) Sense of Purpose and Solution-Seeking Behaviours. The findings highlight that resilience is actively mobilised through family ties, peer groups, and community initiatives, enabling women to adapt to socio-economic hardship and health-related barriers. This study concludes that empowerment strategies, especially community-based programmes focused on skills development and economic opportunities, are essential for enhancing resilience, reducing vulnerability, and improving health outcomes. Strengthening these resources not only equips women to manage HIV-related challenges but also contributes to sustainable development within their communities.

5 February 2026

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J. Ageing Longev. - ISSN 2673-9259