Targeted Mesoporous Silica Nanoparticles (MSNs) for Theranostic Applications
A special issue of Future Pharmacology (ISSN 2673-9879).
Deadline for manuscript submissions: 30 September 2025 | Viewed by 106
Special Issue Editor
Special Issue Information
Dear Colleagues,
Mesoporous silica nanoparticles (MSNs) provide a versatile drug delivery system with notable benefits in drug absorption, distribution, mechanism of action, and precision targeting. They have emerged as a valuable platform for various disease theranostics due to their distinctive features, including a large surface area, adjustable synthesis conditions, easy functionalization, and exceptional biocompatibility. MSNs enhance the solubility and bioavailability of hydrophobic drugs; however, gastrointestinal absorption remains a challenge. Intravenous administration is the one of the most preferred approaches for fast systemic circulation. They also facilitate drug uptake in respiratory and central nervous system disorders due to their high permeability. Additionally, MSNs can be engineered for imaging applications, allowing for the simultaneous diagnosis and treatment (theranostics) of various diseases, including cancer, infectious diseases, and neurodegenerative disorders. Also, there have been ongoing advancements in MSNs for biosensing and tissue engineering applications, as well as a progressive transition from fundamental research to clinical trials. However, MSNs may generate reactive oxygen species, leading to cytotoxicity, and further bare MSNs can disrupt red blood cells and induce clotting, thus surface modifications are required. Also, the inappropriate clearance of large MSNs may lead to liver or spleen toxicity. Thus, although preclinical findings are promising, additional research is required to refine safety, effectiveness, and regulatory compliance for clinical use.
This Special Issue aims to provide an in-depth analysis of the latest advances in mesoporous silica nanoparticle (MSN)-based nanocarriers for improved theranostic applications. This Special Issue welcomes original research articles and reviews focused on (but not limited to) the following research areas:
- MSNs and functionalized MSNs;
- Targeted drug delivery;
- Antimicrobial and anticancer therapies;
- Neurodegenerative diseases;
- Immunotherapy;
- Phototherapy;
- Chemotherapy;
- Pharmacological and molecular mechanisms;
- Pharmacokinetics and biodistribution studies;
- Clinical and preclinical studies;
- Toxicological studies.
Dr. Sabya Sachi Das
Guest Editor
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Keywords
- MSNs and functionalized MSNs
- antimicrobial and anticancer therapies
- immunotherapy
- phototherapy
- chemotherapy
- pharmacological and molecular mechanisms
- pharmacokinetics and biodistribution studies
- clinical and preclinical studies
- toxicological studies
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