Special Issue "Integrins Mediate Cell-Matrix Adhesion"

A special issue of BioChem (ISSN 2673-6411).

Deadline for manuscript submissions: 31 October 2022 | Viewed by 347

Special Issue Editor

Dr. Pranshu Sahgal
E-Mail Website
Guest Editor
Department of Medical Oncology, Dana-Farber Cancer Institute - Harvard Medical School, 450 Brookline Ave, Boston, MA 02215, USA
Interests: breast cancer; gastric cancer; esophageal cancer; colorectal cancer; DNA-damage response; membrane receptors

Special Issue Information

Dear Colleagues,

Integrins are the heterodimeric transmembrane adhesion receptors and act as the “fasteners”, connecting the cells with the extracellular matrix (ECM), or matrix in short. This integrin-mediated interaction of the cells with the matrix is essential for multicellular organisms, contributing from embryogenesis to the higher-level complex body functions and homeostasis. Integrins govern the expression, assembly, and turnover of the different components of the matrix and play a vital role in cell migration, proliferation, invasion, polarity, and mechanotransduction.

Unlike other membrane receptors, which can signal only from outside to in, integrins have the extraordinary potential to function as the bidirectional signaling receptors facilitating inside–out signaling (mediated by intracellular signals) and outside–in signaling (mediated by the ligands in the matrix). Humans have 18 alpha and 8 beta integrin subunits, which constitute 24 distinct integrin heterodimers. Likewise, many different ligands in the matrix can interact with integrins differentially to produce regulated and synchronized activation and inactivation of the integrins, linked with varied cellular responses. Any deregulation in the integrin-mediated cell–matrix interactions and integrin activation/deactivation results in pathological conditions, namely cancer, inflammation, metabolic diseases, bleeding disorders, immune disorders, and neurological disorders, to name a few.

In this Special Issue, we want to pay attention to the complex biology of integrin-mediated cell–matrix interactions and explore the previously unknown phenomenon of this essential regulation directly linked with many diseases. This Special Issue will include contributions on (though not restricted to): ECM (extracellular matrix); ligand binding (e.g., with collagen, fibronectin); cell-matrix interaction; integrin-mediated signal transduction (e.g., AKT, ERK, FAK signaling); integrin crosstalk (e.g., with EGFR, c-MET); cell adhesion; cell migration; matrix remodeling; focal adhesion; focal adhesion turnover; integrin-linked diseases like cancer; targeting integrins, integrin-mediated adhesion; or integrin-mediated signaling (e.g., with small molecule inhibitors or function-blocking antibodies).

Dr. Pranshu Sahgal
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. BioChem is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Integrins
  • ECM (extracellular matrix)
  • cell adhesion
  • cell-adhesion molecules (CAMs)
  • fibronectin
  • laminin
  • collagen
  • Matrix metalloproteinases (MMPs)
  • cell migration
  • cell proliferation
  • integrin signaling
  • focal adhesion
  • focal dynamics
  • integrin crosstalk
  • integrin trafficking
  • mechanosensing
  • cytoskeleton
  • Integrin receptor Inhibitors

Published Papers

This special issue is now open for submission.
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