Correlations between Endoscopic and Histopathological Assessment of Helicobacter pylori-Induced Gastric Pathology—A Cross-Sectional Retrospective Study
Abstract
:1. Introduction
2. Materials and Methods
2.1. Patient Characteristics
2.2. Endoscopy
2.3. Rapid Urease Test (RUT) for the Diagnosis of H. pylori
2.4. Histopathology
2.5. Statistical Analysis
3. Results
3.1. Patient Characteristics
3.2. Endoscopic Diagnostics
Gastric Pathology
3.3. Histopathology
Correlation of Endoscopy and Histopathology Results in H. pylori Positive Patients
- A.
- Atrophic gastritis
- B.
- Gastric metaplasia
- C.
- Correlation of corpus atrophy endoscopy with patients’ age
- D.
- Gender correlation with endoscopic atrophy and metaplasia
- E.
- Gastric polyps
- F.
- Gastric tumors
- G.
- Sensitivity and specificity
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Demographic Data | Number of Cases/Total/Percentage | |
---|---|---|
Female | 63/133 (47.4%) | |
Male | 70/133 (52.6%) | |
Rural | 59/133 (44.4%) | |
Urban | 74/133 (55.6%) | |
Age < 20 | 0/133 (0%) | |
Age 20–29 | 2/133 (1.5%) | |
Age 30–39 | 5/133 (3.8%) | |
Age 40–49 | 16/133 (12%) | |
Age 50–59 | 24/133 (18%) | |
Age 60–69 | 44/133 (33.1%) | |
Age 70–79 | 36/133 (27.1%) | |
Age > 79 | 5/133 (4.5%) | |
Gastric Pathologies (endoscopy) | Number of cases/total/percentage | |
Corpus | Antrum | |
Atrophic Gastritis | 19/133 (14.3%) | 14/133 (10.5%) |
Acute Gastritis | 2/133 (1.5%) | 6/133 (4.5%) |
Chronic Gastritis | 55/133 (41.4%) | 106/133 (79.7%) |
Hypertrophic Gastritis | 13/133 (9.8%) | 19/133 (14.3%) |
Metaplasia | 7/133 (5.3%) | 23/133 (17.3%) |
Polyps | 13/132 (9.8%) | 11/133 (8.3%) |
Ulcer | 10/132 (7.6%) | 18/133 (13.5%) |
Tumor | 4/132 (3.5%) | Not available |
Gastric Pathologies | ||||||
---|---|---|---|---|---|---|
Corpus | Antrum | |||||
Polymorphonuclear cell | 15/55 (27.3%) | 16/65 (24.6%) | ||||
Lymphoplasmocitar cell | 47/55 (85.5%) | 57/65 (87.7%) | ||||
Atrophy | 19/55 (34.5%) | 16/65 (24.6%) | ||||
Complete Metaplasia | 4/55 (7.3%) | All Metaplasia | 6/55 (10.9%) | 19/65 (29.2%) | All Metaplasia | 25/65 (38.5%) |
Incomplete Metaplasia | 2/55 (3.6%) | 6/65 (9.2%) | ||||
Reduced Dysplasia | 7/55 (12.7%) | 13/65 (20%) | ||||
High Dysplasia | 1/55 (1.8%) | 2/65 (3.1%) | ||||
Hyperplasic Polyps | 8/55 (14.5%) | All Polyps | 12/55 (21.8%) | 10/66 (15.2%) | All Polyps | 15/66 (22.7%) |
Adenomatous Polyps | 0/55 (0%) | 1/66 (1.5%) | ||||
Dysplasic Polyps | 0/55 (0%) | 1/66 (1.5%) | ||||
Inflammatory Polyps | 4/55 (7.3%) | 5/66 (7.6%) | ||||
Tumor | 3/55 (5.5%) | 2/66 (3%) | ||||
Giemsa | 22/105 RUT positive (21%) |
Antrum Atrophic Gastritis | Antrum Metaplasia | All Metaplasia | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Correlation between endoscopy and histopathology in antrum atrophic gastritis | Fisher exact test for the correlation of the endoscopic and histopathology results for metaplasia in antrum | Fisher exact test for the correlation of the endoscopic and histopathology results for all metaplasia (both corpus and antrum). | ||||||||||
Histopathology | Total | Histopathology | Total | Histopathology | Total | |||||||
0 | 1 | 0 | 1 | 0 | 1 | |||||||
Endoscopy | 0 | 46 | 9 | 55 | 0 | 31 | 12 | 43 | 0 | 76 | 16 | 92 |
1 | 3 | 7 | 10 | 1 | 9 | 13 | 22 | 1 | 13 | 15 | 28 | |
Total | 49 | 16 | 65 | 40 | 25 | 65 | 89 | 31 | 129 | |||
p = 0.001 * | p = 0.018 * | p << 0.001 * |
Sensitivity (CI) | Specificity (CI) | PPV | NPV | p (Fisher Exact Test) | |
---|---|---|---|---|---|
Antrum Metaplasia | 52% (31–72%) | 77.5% (62–89%) | 59% | 72% | 0.018 * |
All Metaplasia | 48% (30–67%) | 85% (76–92%) | 54% | 83% | <<0.001 * |
Corpus Polyps | 83% (52–98%) | 93% (81–99%) | 77% | 95% | <0.001 * |
Antrum Polyps | 53% (27–79%) | 94% (84–99%) | 73% | 87% | <0.001 * |
Corpus Tumors | 67% (9–99%) | 96% (87–100%) | 50% | 98% | 0.012 * |
Antrum Atrophy | 44% (20–70%) | 94% (83–99%) | 70% | 84% | 0.001 * |
Overall | 55% (43–66%) | 92% (88–95%) | 64% | 88% | <<0.001 * |
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Dănilă, C.; Cardos, I.A.; Pop-Crisan, A.; Marc, F.; Hoza, A.; Chirla, R.; Pascalău, A.; Magheru, C.; Cavalu, S. Correlations between Endoscopic and Histopathological Assessment of Helicobacter pylori-Induced Gastric Pathology—A Cross-Sectional Retrospective Study. Life 2022, 12, 2096. https://doi.org/10.3390/life12122096
Dănilă C, Cardos IA, Pop-Crisan A, Marc F, Hoza A, Chirla R, Pascalău A, Magheru C, Cavalu S. Correlations between Endoscopic and Histopathological Assessment of Helicobacter pylori-Induced Gastric Pathology—A Cross-Sectional Retrospective Study. Life. 2022; 12(12):2096. https://doi.org/10.3390/life12122096
Chicago/Turabian StyleDănilă, Cătălina, Ioana Alexandra Cardos, Andrea Pop-Crisan, Felicia Marc, Anica Hoza, Razvan Chirla, Andrei Pascalău, Calin Magheru, and Simona Cavalu. 2022. "Correlations between Endoscopic and Histopathological Assessment of Helicobacter pylori-Induced Gastric Pathology—A Cross-Sectional Retrospective Study" Life 12, no. 12: 2096. https://doi.org/10.3390/life12122096