We are pleased to highlight eight interesting papers on immune checkpoint inhibitors published in Cells (ISSN: 2073-4409) in 2024 and 2025. These papers provide important insights into immune checkpoint inhibitors, covering immunomodulation, signaling pathways, immunotherapy, and both classical and novel targets. We welcome you to explore these contributions, which reflect recent advances and emerging directions in checkpoint inhibition.

1. “Cancer Vulnerabilities Through Targeting the ATR/Chk1 and ATM/Chk2 Axes in the Context of DNA Damage”
by Anell Fernandez, Maider Artola, Sergio Leon, Nerea Otegui, Aroa Jimeno, Diego Serrano and Alfonso Calvo
Cells 2025, 14(10), 748; https://doi.org/10.3390/cells14100748
Full text available online: https://www.mdpi.com/2073-4409/14/10/748

2. “B7H3 in Gastrointestinal Tumors: Role in Immune Modulation and Cancer Progression: A Review of the Literature”
by Sylwia Mielcarska, Anna Kot, Agnieszka Kula, Miriam Dawidowicz, Piotr Sobków, Daria Kłaczka, Dariusz Waniczek and Elżbieta Świętochowska
Cells 2025, 14(7), 530; https://doi.org/10.3390/cells14070530
Full text available online: https://www.mdpi.com/2073-4409/14/7/530

3. “Exploiting Cancer Dormancy Signaling Mechanisms in Epithelial Ovarian Cancer Through Spheroid and Organoid Analysis”
by Emily J. Tomas, Yudith Ramos Valdes, Jennifer Davis, Bart Kolendowski, Adrian Buensuceso, Gabriel E. DiMattia and Trevor G. Shepherd
Cells 2025, 14(2), 133; https://doi.org/10.3390/cells14020133
Full text available online: https://www.mdpi.com/2073-4409/14/2/133

4. “B-Cell Lymphomas Secrete Novel Inhibitory Molecules That Disrupt HLA Class II-Mediated CD4+ T-Cell Recognition”
by Jason M. God, Shereen Amria, Christine A. Cameron, Lixia Zhang, Jennifer R. Bethard and Azizul Haque
Cells 2025, 14(15), 1220; https://doi.org/10.3390/cells14151220
Full text available online: https://www.mdpi.com/2073-4409/14/15/1220

5. “Transcriptomic Analyses of Ovarian Clear Cell Carcinoma Spheroids Reveal Distinct Proliferative Phenotypes and Therapeutic Vulnerabilities”
by Bart Kolendowski, Sylvia Cheng, Yudith Ramos Valdes, Trevor G. Shepherd and Gabriel E. DiMattia
Cells 2025, 14(11), 785; https://doi.org/10.3390/cells14110785
Full text available online: https://www.mdpi.com/2073-4409/14/11/785

6. “Dihydroorotate Dehydrogenase in Mitochondrial Ferroptosis and Cancer Therapy”
by Jaewang Lee and Jong-Lyel Roh
Cells 2025, 14(23), 1889; https://doi.org/10.3390/cells14231889
Full text available online: https://www.mdpi.com/2073-4409/14/23/1889

7. “Chronic High-Salt Diet Activates Tumor-Initiating Stem Cells Leading to Breast Cancer Proliferation”
by Lisa Tucker, Umer Ali, Roy Zent, Deborah A. Lannigan, Jeffrey C. Rathmell and Venkataswarup Tiriveedhi
Cells 2024, 13(11), 912; https://doi.org/10.3390/cells13110912
Full text available online: https://www.mdpi.com/2073-4409/13/11/912