We are delighted to share a collection of highly viewed papers on molecular cancer biology that were published in Cancers (ISSN: 2072-6694) in the first half of 2025. In addition, some Special Issues on this topic are currently open for submission. The following is a list of articles and Special Issues that we believe may be of interest to you.

The list of relevant papers can be seen below:

“Repeated COVID-19 Vaccination as a Poor Prognostic Factor in Pancreatic Cancer: A Retrospective, Single-Center Cohort Study”
by Makoto Abue, Mai Mochizuki, Rie Shibuya-Takahashi, Kensuke Ota, Yuta Wakui, Wataru Iwai, Jun Kusaka, Masashi Saito, Shinichi Suzuki, Ikuro Sato et al.
Cancers 2025, 17(12), 2006; https://doi.org/10.3390/cancers17122006
Available online: https://www.mdpi.com/2072-6694/17/12/2006

“Reduction of Prostate Cancer Risk: Role of Frequent Ejaculation-Associated Mechanisms”
by Mohamed Hassan, Thomas W. Flanagan, Abdulaziz M. Eshaq, Osama K. Altamimi, Hassan Altalag, Mohamed Alsharif, Nouf Alshammari, Tamadhir Alkhalidi, Abdelhadi Boulifa, Siraj M. El Jamal et al.
Cancers 2025, 17(5), 843; https://doi.org/10.3390/cancers17050843
Available online: https://www.mdpi.com/2072-6694/17/5/843

“The Role of KRAS Mutations in Colorectal Cancer: Biological Insights, Clinical Implications, and Future Therapeutic Perspectives”
by Mitsunobu Takeda, Shoma Yoshida, Takuya Inoue, Yuki Sekido, Tsuyoshi Hata, Atsushi Hamabe, Takayuki Ogino, Norikatsu Miyoshi, Mamoru Uemura, Hirofumi Yamamoto et al.
Cancers 2025, 17(3), 428; https://doi.org/10.3390/cancers17030428
Available online: https://www.mdpi.com/2072-6694/17/3/428

“Heterogeneity in Cancer”
by William J. MacDonald, Connor Purcell, Maximilian Pinho-Schwermann, Nolan M. Stubbs, Praveen R. Srinivasan and Wafik S. El-Deiry
Cancers 2025, 17(3), 441; https://doi.org/10.3390/cancers17030441
Available online: https://www.mdpi.com/2072-6694/17/3/441

“Molecular Insights on Signaling Cascades in Breast Cancer: A Comprehensive Review”
by Venketesh K. Panda, Barnalee Mishra, Samikshya Mahapatra, Biswajit Swain, Diksha Malhotra, Suryendu Saha, Sinjan Khanra, Priyanka Mishra, Sambhunath Majhi, Kavita Kumari et al.
Cancers 2025, 17(2), 234; https://doi.org/10.3390/cancers17020234
Available online:  https://www.mdpi.com/2072-6694/17/2/234

“Deciphering the Role of Cancer Stem Cells: Drivers of Tumor Evolution, Therapeutic Resistance, and Precision Medicine Strategies”
by Mohamed El-Tanani, Syed Arman Rabbani, Shakta Mani Satyam, Imran Rashid Rangraze, Adil Farooq Wali, Yahia El-Tanani and Alaa A. A. Aljabali
Cancers 2025, 17(3), 382; https://doi.org/10.3390/cancers17030382
Available online:  https://www.mdpi.com/2072-6694/17/3/382

Special Issues:

“Growth Factors and Receptor Tyrosine Kinases in Development, Regeneration, and Tumorigenesis (2nd Edition)”
Guest Editor: Prof. Dr. Carl-Henrik Heldin
Submission deadline: 30 November 2025

“PTEN: Regulation, Signalling and Targeting in Cancer”
Guest Editors: Dr. Éric Chastre, Dr. Larissa Kotelevets and Dr. Mark G. H. Scott
Submission deadline: 31 December 2025

“Heterogeneity in Intra-Cranial Tumors: Diagnostic, Prognostic, and Therapeutic Implications”
Guest Editors: Prof. Dr. Francois Ducray, Dr. Shawn L. Hervey-Jumper and Dr. Thiebaud Picart
Submission deadline: 28 February 2026

“Mitochondrial Metabolism and Cancer”
Guest Editor: Prof. Dr. Marcos Roberto de Oliveira
Submission deadline: 31 July 2026

We hope this announcement will provide useful information for the field of molecular cancer biology.